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Bains RS, Cater HL, Sillito RR, et al. Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System. Front Behav Neurosci. 2016;10:106doi: 10.3389/fnbeh.2016.00106.
Bains, R. S., Cater, H. L., Sillito, R. R., Chartsias, A., Sneddon, D., Concas, D., Keskivali-Bond, P., Lukins, T. C., Wells, S., Acevedo Arozena, A., Nolan, P. M., & Armstrong, J. D. (2016). Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System. Frontiers in behavioral neuroscience, 10106. https://doi.org/10.3389/fnbeh.2016.00106
Bains, Rasneer S, et al. "Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System." Frontiers in behavioral neuroscience vol. 10 (2016): 106. doi: https://doi.org/10.3389/fnbeh.2016.00106
Bains RS, Cater HL, Sillito RR, Chartsias A, Sneddon D, Concas D, Keskivali-Bond P, Lukins TC, Wells S, Acevedo Arozena A, Nolan PM, Armstrong JD. Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System. Front Behav Neurosci. 2016 Jun 10;10:106. doi: 10.3389/fnbeh.2016.00106. eCollection 2016. PMID: 27375446; PMCID: PMC4901040.
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Front Behav Neurosci. 2016 Jun 10;10:106. doi: 10.3389/fnbeh.2016.00106. eCollection 2016.

Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System.

Frontiers in behavioral neuroscience

Rasneer S Bains, Heather L Cater, Rowland R Sillito, Agisilaos Chartsias, Duncan Sneddon, Danilo Concas, Piia Keskivali-Bond, Timothy C Lukins, Sara Wells, Abraham Acevedo Arozena, Patrick M Nolan, J Douglas Armstrong

Affiliations

  1. Mary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK.
  2. Actual Analytics Ltd Edinburgh, UK.
  3. Mammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, UK.
  4. Actual Analytics LtdEdinburgh, UK; School of Informatics, University of EdinburghEdinburgh, UK.

PMID: 27375446 PMCID: PMC4901040 DOI: 10.3389/fnbeh.2016.00106

Abstract

Central nervous system disorders such as autism as well as the range of neurodegenerative diseases such as Huntington's disease are commonly investigated using genetically altered mouse models. The current system for characterizing these mice usually involves removing the animals from their home-cage environment and placing them into novel environments where they undergo a battery of tests measuring a range of behavioral and physical phenotypes. These tests are often only conducted for short periods of times in social isolation. However, human manifestations of such disorders are often characterized by multiple phenotypes, presented over long periods of time and leading to significant social impacts. Here, we have developed a system which will allow the automated monitoring of individual mice housed socially in the cage they are reared and housed in, within established social groups and over long periods of time. We demonstrate that the system accurately reports individual locomotor behavior within the group and that the measurements taken can provide unique insights into the effects of genetic background on individual and group behavior not previously recognized.

Keywords: C57BL/6 mice; circadian rhythm; inbred mouse strains; mouse behavior; mouse models; strain differences

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