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Limberg JK, Peltonen GL, Johansson RE, et al. Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives. Front Physiol. 2016;7:215doi: 10.3389/fphys.2016.00215.
Limberg, J. K., Peltonen, G. L., Johansson, R. E., Harrell, J. W., Kellawan, J. M., Eldridge, M. W., Sebranek, J. J., Walker, B. J., & Schrage, W. G. (2016). Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives. Frontiers in physiology, 7215. https://doi.org/10.3389/fphys.2016.00215
Limberg, Jacqueline K, et al. "Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives." Frontiers in physiology vol. 7 (2016): 215. doi: https://doi.org/10.3389/fphys.2016.00215
Limberg JK, Peltonen GL, Johansson RE, Harrell JW, Kellawan JM, Eldridge MW, Sebranek JJ, Walker BJ, Schrage WG. Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives. Front Physiol. 2016 Jun 08;7:215. doi: 10.3389/fphys.2016.00215. eCollection 2016. PMID: 27375493; PMCID: PMC4896959.
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Front Physiol. 2016 Jun 08;7:215. doi: 10.3389/fphys.2016.00215. eCollection 2016.

Greater Beta-Adrenergic Receptor Mediated Vasodilation in Women Using Oral Contraceptives.

Frontiers in physiology

Jacqueline K Limberg, Garrett L Peltonen, Rebecca E Johansson, John W Harrell, Jeremy M Kellawan, Marlowe W Eldridge, Joshua J Sebranek, Benjamin J Walker, William G Schrage

Affiliations

  1. Department of Kinesiology, University of Wisconsin Madison, WI, USA.
  2. Department of Kinesiology, University of WisconsinMadison, WI, USA; Department of Pediatrics, University of WisconsinMadison, WI, USA.
  3. Department of Anesthesiology, University of Wisconsin Madison, WI, USA.

PMID: 27375493 PMCID: PMC4896959 DOI: 10.3389/fphys.2016.00215

Abstract

BACKGROUND: β-adrenergic receptors play an important role in mitigating the pressor effects of sympathetic nervous system activity in young women. Based on recent data showing oral contraceptive use in women abolishes the relationship between muscle sympathetic nervous system activity and blood pressure, we hypothesized forearm blood flow responses to a β-adrenergic receptor agonist would be greater in young women currently using oral contraceptives (OC+, n = 13) when compared to those not using oral contraceptives (OC-, n = 10).

METHODS: Women (18-35 years) were studied during the early follicular phase of the menstrual cycle (days 1-5) or placebo phase of oral contraceptive use. Forearm blood flow (FBF, Doppler ultrasound) and mean arterial blood pressure (MAP, brachial arterial catheter) were measured at baseline and during graded brachial artery infusion of the β-adrenergic receptor agonist, Isoproterenol (ISO), as well as Acetylcholine (ACH, endothelium-dependent vasodilation) and Nitroprusside (NTP, endothelium-independent vasodilation). Forearm vascular conductance was calculated (FVC = FBF/MAP, ml/min/100 mmHg) and the rise in FVC from baseline during infusion quantified vasodilation (ΔFVC = FVCinfusion - FVCbaseline).

RESULTS: ISO increased FVC in both groups (p < 0.01) and ISO-mediated ΔFVC was greater in OC+ compared to OC- (Main effect of group, p = 0.02). Expressing data as FVC and FBF resulted in similar conclusions. FVC responses to both ACH and NTP were also greater in OC+ compared to OC-.

CONCLUSIONS: These data are the first to demonstrate greater β-adrenergic receptor-mediated vasodilation in the forearm of women currently using oral contraceptives (placebo phase) when compared to those not using oral contraceptives (early follicular phase), and suggest oral contraceptive use influences neurovascular control.

Keywords: blood flow; endothelium-dependent vasodilation; isoproterenol; neural control; smooth muscle

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