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Västermark Å, Rask-Andersen M, Sawant RS, et al. Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA. J Syst Evol. 2013;51(6):664-670doi: 10.1111/jse.12048.
Västermark, �. �., Rask-Andersen, M., Sawant, R. S., Reiter, J. L., Schiöth, H. B., & Williams, M. J. (2013). Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA. Journal of systematics and evolution, 51(6), 664-670. https://doi.org/10.1111/jse.12048
Västermark, Åke, et al. "Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA." Journal of systematics and evolution vol. 51,6 (2013): 664-670. doi: https://doi.org/10.1111/jse.12048
Västermark Å, Rask-Andersen M, Sawant RS, Reiter JL, Schiöth HB, Williams MJ. Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA. J Syst Evol. 2013 Nov;51(6):664-670. doi: 10.1111/jse.12048. Epub 2013 Sep 02. PMID: 27375681; PMCID: PMC4926259.
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J Syst Evol. 2013 Nov;51(6):664-670. doi: 10.1111/jse.12048. Epub 2013 Sep 02.

Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA.

Journal of systematics and evolution

Åke Västermark, Mathias Rask-Andersen, Rahul S Sawant, Jill L Reiter, Helgi B Schiöth, Michael J Williams

Affiliations

  1. Department of Neuroscience, Uppsala University, Uppsala, Sweden.
  2. Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

PMID: 27375681 PMCID: PMC4926259 DOI: 10.1111/jse.12048

Abstract

Truncated receptor ectodomains have been described for several classes of cell surface receptors, including those that bind to growth factors, cytokines, immunoglobulins, and adhesion molecules. Soluble receptor isoforms are typically generated by proteolytic cleavage of the cell surface receptor or by alternative splicing of RNA transcripts arising from the same gene encoding the full-length receptor. Both the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) families produce soluble receptor splice variants in vertebrates and truncated forms of insulin receptor-like sequences have previously been described in

Keywords: Drosophila; INSR; INSRR; Tribolium castaneum; ectodomain; receptor L domain

References

  1. J Biol Chem. 1993 Aug 25;268(24):17983-6 - PubMed
  2. Endocrinology. 1993 Jul;133(1):3-10 - PubMed
  3. PLoS One. 2008;3(11):e3667 - PubMed
  4. Annu Rev Pharmacol Toxicol. 2013;53:127-46 - PubMed
  5. Genetics. 2010 May;185(1):65-80 - PubMed
  6. Mol Biol Evol. 2008 Jun;25(6):1043-53 - PubMed
  7. Biol Bull. 1999 Oct;197(2):198-206 - PubMed
  8. Endocrinology. 1995 Sep;136(9):4125-32 - PubMed
  9. Nature. 2008 Jun 26;453(7199):1271-5 - PubMed
  10. Genome Res. 2012 Oct;22(10):2067-78 - PubMed
  11. Funct Integr Genomics. 2001 Mar;1(4):250-5 - PubMed
  12. BMC Evol Biol. 2010 Oct 12;10:305 - PubMed
  13. Genomics. 2001 Jan 1;71(1):1-20 - PubMed
  14. BMC Evol Biol. 2010 Jan 27;10:27 - PubMed
  15. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8443-7 - PubMed
  16. Endocrinology. 2011 Jun;152(6):2278-89 - PubMed
  17. Genetica. 1992;87(2):95-100 - PubMed
  18. Bioinformatics. 2011 Apr 15;27(8):1164-5 - PubMed
  19. J Biol Chem. 1988 Feb 15;263(5):2553-62 - PubMed
  20. Bioessays. 2004 Dec;26(12):1351-62 - PubMed
  21. Cell Metab. 2011 Jun 8;13(6):679-89 - PubMed
  22. Nucleic Acids Res. 1996 Oct 15;24(20):4050-6 - PubMed
  23. Mol Biol Evol. 2008 Jul;25(7):1307-20 - PubMed
  24. Mol Biol Evol. 2009 Jan;26(1):47-59 - PubMed

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