Display options
Cite
Xu XY, Li WY, Hu XY. Alteration of Thyroid-Related Hormones within Normal Ranges and Early Functional Outcomes in Patients with Acute Ischemic Stroke. Int J Endocrinol. 2016;2016:3470490doi: 10.1155/2016/3470490.
Xu, X. Y., Li, W. Y., & Hu, X. Y. (2016). Alteration of Thyroid-Related Hormones within Normal Ranges and Early Functional Outcomes in Patients with Acute Ischemic Stroke. International journal of endocrinology, 20163470490. https://doi.org/10.1155/2016/3470490
Xu, Xiao-Yan, et al. "Alteration of Thyroid-Related Hormones within Normal Ranges and Early Functional Outcomes in Patients with Acute Ischemic Stroke." International journal of endocrinology vol. 2016 (2016): 3470490. doi: https://doi.org/10.1155/2016/3470490
Xu XY, Li WY, Hu XY. Alteration of Thyroid-Related Hormones within Normal Ranges and Early Functional Outcomes in Patients with Acute Ischemic Stroke. Int J Endocrinol. 2016;2016:3470490. doi: 10.1155/2016/3470490. Epub 2016 Jun 08. PMID: 27375741; PMCID: PMC4916307.
Copy Download .nbib Format: NLM
Share it on

Int J Endocrinol. 2016;2016:3470490. doi: 10.1155/2016/3470490. Epub 2016 Jun 08.

Alteration of Thyroid-Related Hormones within Normal Ranges and Early Functional Outcomes in Patients with Acute Ischemic Stroke.

International journal of endocrinology

Xiao-Yan Xu, Wen-Yu Li, Xing-Yue Hu

Affiliations

  1. Department of Neurology, The Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.

PMID: 27375741 PMCID: PMC4916307 DOI: 10.1155/2016/3470490

Abstract

This study evaluated the prognostic value of thyroid-related hormones within normal ranges after acute ischemic stroke. This was a retrospective study and we reviewed 1072 ischemic stroke patients consecutively admitted within 72 h after symptom onset. Total triiodothyronine (T3), total thyroxine (T4), free T3, free T4, and thyroid-stimulating hormone (TSH) were assessed to determine their values for predicting functional outcome at the first follow-up clinic visits, which usually occurred 2 to 4 weeks after discharge from the hospital. 722 patients were finally included. On univariate analysis, poor functional outcome was associated with presence of atrial fibrillation as the index event. Furthermore, score of National Institutes of Health Stroke Scale (NIHSS), total T4, free T4, and C-reactive protein at admission were significantly higher in patients with poor functional outcome, whereas free T3 and total T3 were significantly lower. On multiple logistic regression analysis, lower total T3 concentrations remained independently associated with poor functional outcome [odds ratio (OR), 0.10; 95% confidence interval (CI), 0.01-0.84; P = 0.035]. The only other variables independently associated with poor functional outcome were NIHSS scores. In sum, lower total T3 concentrations that were within the normal ranges were independently associated with poor short-term outcomes.

References

  1. Crit Care Med. 1995 Jan;23(1):78-83 - PubMed
  2. J Neuroendocrinol. 2009 May;21(5):465-72 - PubMed
  3. Exp Clin Endocrinol Diabetes. 2011 Mar;119(3):139-43 - PubMed
  4. J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):725-7 - PubMed
  5. Endocr Rev. 2002 Feb;23(1):38-89 - PubMed
  6. Horm Metab Res. 2006 Sep;38(9):587-91 - PubMed
  7. J Neurol. 2009 Dec;256(12):2003-8 - PubMed
  8. Stroke Res Treat. 2010 Aug 09;2010:null - PubMed
  9. Endocrine. 2014 Mar;45(2):213-20 - PubMed
  10. Eur J Endocrinol. 2004 Nov;151(5):557-60 - PubMed
  11. Stroke. 2005 Jun;36(6):1316-29 - PubMed
  12. Metabolism. 2007 Feb;56(2):239-44 - PubMed
  13. Clin Endocrinol (Oxf). 1993 Nov;39(5):499-518 - PubMed
  14. Exp Gerontol. 2015 Jan;61:8-14 - PubMed
  15. Circulation. 2003 Feb 11;107(5):708-13 - PubMed
  16. Expert Rev Neurother. 2015 Mar;15(3):315-26 - PubMed
  17. Eur J Clin Invest. 2007 Aug;37(8):651-7 - PubMed
  18. Endocr Rev. 1982 Spring;3(2):164-217 - PubMed
  19. J Intern Med. 2011 Apr;269(4):420-32 - PubMed
  20. J Neurosurg. 2013 Jun;118(6):1279-87 - PubMed

Publication Types