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Thulasi Raman R, Manimaran D, Rachakatla P, et al. Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status. J Clin Diagn Res. 2016;10(5):EC04-6doi: 10.7860/JCDR/2016/17459.7718.
Thulasi Raman, R., Manimaran, D., Rachakatla, P., Bharathi, K., Afroz, T., & Sagar, R. (2016). Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status. Journal of clinical and diagnostic research : JCDR, 10(5), EC04-6. https://doi.org/10.7860/JCDR/2016/17459.7718
Thulasi Raman, R, et al. "Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status." Journal of clinical and diagnostic research : JCDR vol. 10,5 (2016): EC04-6. doi: https://doi.org/10.7860/JCDR/2016/17459.7718
Thulasi Raman R, Manimaran D, Rachakatla P, Bharathi K, Afroz T, Sagar R. Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status. J Clin Diagn Res. 2016 May;10(5):EC04-6. doi: 10.7860/JCDR/2016/17459.7718. Epub 2016 May 01. PMID: 27437222; PMCID: PMC4948398.
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J Clin Diagn Res. 2016 May;10(5):EC04-6. doi: 10.7860/JCDR/2016/17459.7718. Epub 2016 May 01.

Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status.

Journal of clinical and diagnostic research : JCDR

R Thulasi Raman, D Manimaran, Praveen Rachakatla, K Bharathi, Tameem Afroz, Radha Sagar

Affiliations

  1. Assistant Professor, Department of Pathology, Shri Sathya Sai Medical College and Research Institute , Ammapettai, Chengalpet Taluk, Kancheepuram District, Tamil Nadu, India .
  2. Professor, Department of Pathology, Tagore Medical College and Hospital , Vandalur-Kelambakkam Road, Rathinamangalam, Tamil Nadu, India .
  3. Senior Resident, Department of Pathology, Kakatiya Medical College, Warangal, Telangana, India.
  4. Associate Professor, Department of Pathology, Shri Sathya Sai Medical College and Research Institute , Ammapettai, Chengalpet Taluk, Kancheepuram District, Tamil Nadu, India .
  5. Senior Consultant, Department of Pathology, Aware Global Hospitals , Hyderabad, Telangana, India .
  6. Head of Department and Senior Consultant, Department of Pathology, Aware Global Hospitals , Hyderabad, Telangana, India .

PMID: 27437222 PMCID: PMC4948398 DOI: 10.7860/JCDR/2016/17459.7718

Abstract

INTRODUCTION: HIV infection is known to cause coagulation abnormalities by various mechanism, especially during its late course.

AIM: The objective of this study was to analyse platelet count, prothrombin time and activated partial thromboplastin time among HIV infected patients and to analyse these parameters with respect to their CD4 count and ART status.

MATERIALS AND METHODS: A case control study was conducted with 120 HIV infected patients and 40 normal individuals. The blood samples were collected after obtaining consent from the subjects. The blood samples were processed for platelet count, prothrombin time and activated partial thromboplastin time and CD4 count. The results were tabulated and analysed with statistical package.

RESULTS: The platelet count was significantly decreased in HIV infected patients compared to controls. Though HIV patients with CD4 count less than 200cells/mm(3) showed a decreased platelet count compared to those with CD4 count greater than 200cells/mm(3), it was not statistically significant. Prothrombin Time (PT) and Activated Partial Thromboplastin Time (aPTT) was significantly prolonged in HIV patients, but only aPTT showed significant inverse correlation with CD4 count. None of the parameters showed statistical significance on comparing HIV patients on ART with those not on ART.

CONCLUSION: Basic coagulation tests like platelet count, PT and especially aPTT can be used as prospective screening test to assess severity in HIV patients in resource limited settings where CD4 count is not available.

Keywords: Activated partial thromboplastin time; Anti-retroviral agents; Blood coagulation; Prothrombin time

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