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Gaul C, Gräter H, Weiser T. Results from a pharmacy-based patient survey on the use of a fixed combination analgesic containing acetylsalicylic acid, paracetamol and caffeine by self-diagnosing and self-treating patients. Springerplus. 2016;5(1):721doi: 10.1186/s40064-016-2369-0.
Gaul, C., Gräter, H., & Weiser, T. (2016). Results from a pharmacy-based patient survey on the use of a fixed combination analgesic containing acetylsalicylic acid, paracetamol and caffeine by self-diagnosing and self-treating patients. SpringerPlus, 5(1), 721. https://doi.org/10.1186/s40064-016-2369-0
Gaul, Charly, et al. "Results from a pharmacy-based patient survey on the use of a fixed combination analgesic containing acetylsalicylic acid, paracetamol and caffeine by self-diagnosing and self-treating patients." SpringerPlus vol. 5,1 (2016): 721. doi: https://doi.org/10.1186/s40064-016-2369-0
Gaul C, Gräter H, Weiser T. Results from a pharmacy-based patient survey on the use of a fixed combination analgesic containing acetylsalicylic acid, paracetamol and caffeine by self-diagnosing and self-treating patients. Springerplus. 2016 Jun 14;5(1):721. doi: 10.1186/s40064-016-2369-0. eCollection 2016. PMID: 27375990; PMCID: PMC4908082.
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Springerplus. 2016 Jun 14;5(1):721. doi: 10.1186/s40064-016-2369-0. eCollection 2016.

Results from a pharmacy-based patient survey on the use of a fixed combination analgesic containing acetylsalicylic acid, paracetamol and caffeine by self-diagnosing and self-treating patients.

SpringerPlus

Charly Gaul, Heidemarie Gräter, Thomas Weiser

Affiliations

  1. Migraine and Headache Clinic Königstein, Ölmühlweg 31, 61462 Königstein im Taunus, Germany.
  2. Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.

PMID: 27375990 PMCID: PMC4908082 DOI: 10.1186/s40064-016-2369-0

Abstract

BACKGROUND: Patients suffering from migraine or tension-type headache (TTH) often treat their complaints with over-the-counter (OTC) medications. Fixed dose combinations of acetylsalicylic acid, paracetamol and caffeine (APC) are among the most commonly used analgesics, and their efficacy for treating acute headache pain has been well demonstrated. This investigation was run to better characterize patients who treat their headache with OTC APC combinations, as well as treatment effects.

METHODS: A pharmacy-based patient survey in 164 German pharmacies was performed. Patients (age ≥18 years) who purchased APC analgesics (of the brand Thomapyrin(®)) were handed a questionnaire, which had to be filled out at patients own discretion after taking the medication. Demographics, pain characteristics and perceived efficacy and tolerability data were analysed with descriptive statistics.

RESULTS: Questionnaires from 1298 patients were analysed, of whom 71.9 % were females and 28.1 % were males. Headache patients were assigned to TTH or migraine according to diagnosis criteria of the International Headache Classification-II (ICHD-II), with 828 patients for TTH and 206 for migraine. About one third of patients in the subgroup migraine did not report their pain as migraine. Nausea, photophobia/phonophobia turned out to be the most distinguishing feature between migraine and TTH. The main reasons for purchasing the product were recommendation by the pharmacists (40.5 %) and/or friends or relatives (24.4 %). 74 % of TTH and 55 % of migraine patients reported onset of pain relief within the first 30 min. More than 90 % rated efficacy as well as tolerability to be "good" or "very good".

CONCLUSIONS: The main reason for purchasing APC products in the pharmacy are TTH or migraine. About a third of patients fulfilling the IHCD-II criteria for migraine failed to recognize their headache as migraine. This could be explained e.g. by patients' misconceptions about their pain. Patients' assessments of efficacy and tolerability showed that the investigated APC combinations are valuable for the treatment of TTH and migraine headache. These data complement those of randomized clinical studies on such preparations.

Keywords: Acetylsalicylic acid; Caffeine; Headache; Migraine; Paracetamol

References

  1. Int J Clin Pharmacol Res. 1998;18(3):145-50 - PubMed
  2. Cephalalgia. 2005 Oct;25(10):776-87 - PubMed
  3. Headache. 2006 Mar;46(3):444-53 - PubMed
  4. J Headache Pain. 2011 Apr;12(2):201-17 - PubMed
  5. Headache. 2009 May;49(5):646-54 - PubMed
  6. Cephalalgia. 2009 Jan;29(1):48-57 - PubMed
  7. Arch Neurol. 1998 Feb;55(2):210-7 - PubMed
  8. MMW Fortschr Med. 2007 May 21;149 Suppl 2:79-82 - PubMed
  9. Cephalalgia. 2008 Sep;28 Suppl 2:28-35 - PubMed
  10. JAMA. 1984 Apr 6;251(13):1711-8 - PubMed
  11. Cochrane Database Syst Rev. 2014 Dec 11;(12):CD009281 - PubMed
  12. Expert Rev Neurother. 2006 Jul;6(7):1087-97 - PubMed
  13. Cephalalgia. 2004 Nov;24(11):947-54 - PubMed
  14. Clin Pharmacol Ther. 1983 Apr;33(4):498-509 - PubMed
  15. Neurology. 2015 Feb 17;84(7):688-95 - PubMed
  16. Eur Neurol. 2004;52(1):50-6 - PubMed
  17. J Headache Pain. 2014 Nov 19;15:76 - PubMed
  18. Med Monatsschr Pharm. 2009 Aug;32(8):301-6 - PubMed
  19. Cephalalgia. 2009 Dec;29(12):1285-93 - PubMed
  20. Cochrane Database Syst Rev. 2015 Jul 14;(7):CD011509 - PubMed
  21. Headache. 2005 Sep;45(8):973-82 - PubMed
  22. Clin Pharmacol Ther. 1994 Nov;56(5):576-86 - PubMed
  23. Cephalalgia. 2000 Sep;20(7):663-7 - PubMed

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