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J Clin Diagn Res. 2016 May;10(5):SD01-2. doi: 10.7860/JCDR/2016/19765.7773. Epub 2016 May 01.

Acute Painful Neuropathy in a Girl with Type 1 Diabetes: Long Term Follow-Up.

Journal of clinical and diagnostic research : JCDR

Devi Dayal, Dhaarani Jayaraman, Naveen Sankhyan, Pratibha Singhi

Affiliations

  1. Additional Professor, Department of Pediatrics, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
  2. Senior Resident, Department of Pediatrics, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
  3. Associate Professor, Department of Pediatrics, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
  4. Professor and Head, Department of Pediatrics, Chief, Pediatric Neurology and Neurodevelopment Unit, Postgraduate Institute of Medical Education and Research , Chandigarh, India .

PMID: 27437321 PMCID: PMC4948497 DOI: 10.7860/JCDR/2016/19765.7773

Abstract

Acute Painful Diabetic Neuropathy (APDN) is a reversible neuropathy that occurs in patients with diabetes usually after a fast improvement in glycaemic control. The condition is extremely rare in children with Type 1 Diabetes (T1D). We describe a 12-year-old girl T1D who developed APDN shortly after diagnosis of T1D. Neurological examination and nerve conduction studies showed severe asymmetric lower limb sensorimotor neuropathy. She was treated with carbamazepine, benfotiamine (vitamin B1 analogue), and NSAID analgesics and showed complete recovery 9 months after the onset. The treating physicians should recognize and understand this entity in view of the current recommendations for quick achievement of glycaemic targets in T1D, the need to provide relief from severe pain and to lay emphasis on complete recovery.

Keywords: Benfotiamine; Children; Glycaemic control; Insulin

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