Display options
Cite
Zlamy M. Rediscovering Pertussis. Front Pediatr. 2016;4:52doi: 10.3389/fped.2016.00052.
Zlamy, M. (2016). Rediscovering Pertussis. Frontiers in pediatrics, 452. https://doi.org/10.3389/fped.2016.00052
Zlamy, Manuela. "Rediscovering Pertussis." Frontiers in pediatrics vol. 4 (2016): 52. doi: https://doi.org/10.3389/fped.2016.00052
Zlamy M. Rediscovering Pertussis. Front Pediatr. 2016 Jun 08;4:52. doi: 10.3389/fped.2016.00052. eCollection 2016. PMID: 27376050; PMCID: PMC4896922.
Copy Download .nbib Format: NLM
Share it on

Front Pediatr. 2016 Jun 08;4:52. doi: 10.3389/fped.2016.00052. eCollection 2016.

Rediscovering Pertussis.

Frontiers in pediatrics

Manuela Zlamy

Affiliations

  1. Department of Pediatrics, Medical University of Innsbruck , Innsbruck , Austria.

PMID: 27376050 PMCID: PMC4896922 DOI: 10.3389/fped.2016.00052

Abstract

Pertussis, caused by Bordetella (B.) pertussis, a Gram-negative bacterium, is a highly contagious airway infection. Especially in infants, pertussis remains a major health concern. Acute infection with B. pertussis can cause severe illness characterized by severe respiratory failure, pulmonary hypertension, leucocytosis, and death. Over the past years, rising incidence rates of intensive care treatment in young infants were described. Due to several virulence factors (pertussis toxin, tracheal cytotoxin, adenylate cyclase toxin, filamentous hemagglutinin, and lipooligosaccharide) that promote bacterial adhesion and invasion, B. pertussis creates a unique niche for colonization within the human respiratory tract. The resulting long-term infection is mainly caused by the ability of B. pertussis to interfere with the host's innate and adaptive immune system. Although pertussis is a vaccine-preventable disease, it has persisted in vaccinated populations. Epidemiological data reported a worldwide increase in pertussis incidence among children during the past years. Either acellular pertussis (aP) vaccines or whole-cell vaccines are worldwide used. Recent studies did not detect any differences according to pertussis incidence when comparing the different vaccines used. Most of the currently used aP vaccines protect against acute infections for a period of 6-8 years. The resurgence of pertussis may be due to the lack of herd immunity caused by missing booster immunizations among adolescents and adults, low vaccine coverages in some geographic areas, and genetic changes of different B. pertussis strains. Due to the rising incidence of pertussis, probable solution strategies are discussed. Cocooning strategies (vaccination of close contact persons) and immunizations during pregnancy appear to be an approach to reduce neonatal contagiousness. During the past years, studies focused on the pathway of the immune modulation done by B. pertussis to provide a basis for the identification of new therapeutic targets to enhance the host's immune response and to probably modulate certain virulence factors.

Keywords: herd immunity; pertussis; vaccination; vaccine-preventable disease; whooping cough

References

  1. J Clin Microbiol. 2012 Jul;50(7):2186-90 - PubMed
  2. Emerg Infect Dis. 2009 Aug;15(8):1206-13 - PubMed
  3. PLoS Comput Biol. 2015 Apr 23;11(4):e1004138 - PubMed
  4. Infect Immun. 1997 Dec;65(12):4904-8 - PubMed
  5. Clin Vaccine Immunol. 2009 Dec;16(12):1816-21 - PubMed
  6. Clin Vaccine Immunol. 2007 Mar;14(3):288-92 - PubMed
  7. Pediatr Infect Dis J. 2005 May;24(5 Suppl):S10-8 - PubMed
  8. Vaccine. 2013 Apr 8;31(15):1981-6 - PubMed
  9. Lancet. 2014 Oct 25;384(9953):1521-8 - PubMed
  10. MMWR Morb Mortal Wkly Rep. 2013 Feb 22;62(7):131-5 - PubMed
  11. BMC Med. 2015 Jun 24;13:146 - PubMed
  12. FEMS Immunol Med Microbiol. 2006 Oct;48(1):140-7 - PubMed
  13. Clin Exp Immunol. 2012 Sep;169(3):281-91 - PubMed
  14. J Exp Med. 2009 Dec 21;206(13):3073-88 - PubMed
  15. J Immunol. 2004 Aug 1;173(3):1934-40 - PubMed
  16. J Immunol. 2003 Feb 1;170(3):1504-9 - PubMed
  17. Eur J Immunol. 2000 Feb;30(2):415-22 - PubMed
  18. Pediatr Infect Dis J. 2013 Nov;32(11):1257-60 - PubMed
  19. Clin Microbiol Rev. 2015 Oct;28(4):1005-26 - PubMed
  20. Pediatr Infect Dis J. 2005 May;24(5 Suppl):S25-34 - PubMed
  21. PLoS One. 2010 Jan 15;5(1):e8734 - PubMed
  22. Vaccine. 2013 Dec 17;32(1):111-8 - PubMed
  23. Clin Immunol. 2015 Apr;157(2):205-15 - PubMed
  24. Immunology. 1998 Jan;93(1):1-10 - PubMed
  25. Infect Immun. 1996 Oct;64(10):4078-84 - PubMed
  26. BMC Public Health. 2013 Jul 23;13:676 - PubMed
  27. Infect Control Hosp Epidemiol. 2006 Jan;27(1):95-7 - PubMed
  28. Future Microbiol. 2010 Mar;5(3):455-69 - PubMed
  29. Vaccine. 2016 Feb 17;34(8):1062-9 - PubMed
  30. Pediatr Infect Dis J. 2015 Sep;34(9):e222-32 - PubMed
  31. JAMA. 1995 Apr 5;273(13):1044-6 - PubMed
  32. Infect Immun. 1993 Feb;61(2):399-410 - PubMed
  33. Infect Immun. 2004 Mar;72(3):1450-62 - PubMed
  34. Microbiology. 1996 Nov;142 ( Pt 11):3261-8 - PubMed
  35. Infect Immun. 1997 Jun;65(6):2168-74 - PubMed
  36. Vaccine. 2012 Feb 21;30(9):1667-74 - PubMed
  37. Infect Immun. 2000 Mar;68(3):1235-42 - PubMed
  38. Epidemiology. 2012 Nov;23(6):852-60 - PubMed
  39. Curr Opin Immunol. 2001 Feb;13(1):89-95 - PubMed
  40. Eur J Pediatr. 2008 Sep;167(9):1017-9 - PubMed
  41. FEMS Microbiol Rev. 2011 May;35(3):441-74 - PubMed
  42. J Immunol. 2009 Jul 1;183(1):400-10 - PubMed
  43. BMC Infect Dis. 2014 Jul 17;14:397 - PubMed
  44. FEMS Microbiol Lett. 1996 Jan 1;135(1):131-5 - PubMed
  45. J Exp Med. 2001 May 7;193(9):1035-44 - PubMed
  46. Pediatr Infect Dis J. 2010 Nov;29(11):1013-5 - PubMed
  47. Front Immunol. 2014 Sep 16;5:446 - PubMed
  48. J Immunol. 2005 Jul 15;175(2):730-8 - PubMed
  49. Vaccine. 2008 Dec 9;26(52):6929-35 - PubMed
  50. Pediatr Infect Dis J. 2005 May;24(5 Suppl):S19-24 - PubMed
  51. J Immunol. 2006 Dec 1;177(11):7980-9 - PubMed
  52. J Rheumatol. 2009 Dec;36(12):2715-23 - PubMed
  53. Pediatr Infect Dis J. 1999 Apr;18(4):366-70 - PubMed
  54. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7259-64 - PubMed
  55. Pediatr Infect Dis J. 2016 Jan;35(1):39-44 - PubMed
  56. Pathog Dis. 2015 Oct;73(7):null - PubMed
  57. J Clin Immunol. 2006 Mar;26(2):153-9 - PubMed
  58. Vaccine. 2014 Feb 12;32(8):996-1002 - PubMed
  59. BMC Infect Dis. 2013 Mar 11;13:129 - PubMed
  60. Expert Rev Anti Infect Ther. 2015 Aug;13(8):965-71 - PubMed
  61. J Infect Dis. 2014 Apr 1;209 Suppl 1:S10-5 - PubMed
  62. J Emerg Med. 2011 Mar;40(3):256-61 - PubMed
  63. FEMS Immunol Med Microbiol. 2009 Jul;56(2):143-50 - PubMed
  64. Int Immunol. 1998 May;10(5):651-62 - PubMed
  65. PLoS One. 2012;7(7):e41928 - PubMed
  66. Clin Infect Dis. 2016 Apr 1;62(7):829-36 - PubMed
  67. N Engl J Med. 1996 Feb 8;334(6):349-55 - PubMed
  68. Crit Rev Microbiol. 2004;30(3):187-96 - PubMed
  69. J Immunol. 2003 Sep 15;171(6):3119-27 - PubMed
  70. Clin Infect Dis. 2015 Dec 1;61(11):1637-44 - PubMed
  71. Mol Microbiol. 1993 Aug;9(4):653-60 - PubMed
  72. Eur J Med Res. 1998 Nov 17;3(11):523-6 - PubMed
  73. Trends Immunol. 2002 Sep;23(9):450-5 - PubMed
  74. Paediatr Respir Rev. 2008 Sep;9(3):201-11; quiz 211-2 - PubMed
  75. Mucosal Immunol. 2012 Sep;5(5):485-500 - PubMed
  76. PLoS One. 2010 Dec 30;5(12):e16009 - PubMed
  77. Clin Infect Dis. 2004 Jul 15;39(2):179-85 - PubMed
  78. JAMA. 2014 May 7;311(17):1760-9 - PubMed
  79. Epidemiol Infect. 2014 Apr;142(4):672-84 - PubMed
  80. J Immunol. 2010 Aug 1;185(3):1711-9 - PubMed
  81. J Clin Microbiol. 2005 Oct;43(10):4925-9 - PubMed
  82. Expert Rev Vaccines. 2014 Sep;13(9):1107-14 - PubMed
  83. Clin Infect Dis. 2008 Aug 1;47(3):328-38 - PubMed
  84. Infect Immun. 2009 Mar;77(3):1182-8 - PubMed
  85. J Clin Microbiol. 1993 Jul;31(7):1715-25 - PubMed
  86. Infect Immun. 2012 Feb;80(2):850-9 - PubMed
  87. Lancet Infect Dis. 2006 Feb;6(2):112-7 - PubMed
  88. Pediatr Infect Dis J. 2015 Jan;34(1):22-6 - PubMed
  89. PLoS One. 2011 Mar 08;6(3):e17271 - PubMed
  90. Cell Microbiol. 2011 Jan;13(1):123-34 - PubMed
  91. Pediatr Infect Dis J. 2013 Jun;32(6):695-8 - PubMed
  92. J Infect Dis. 2003 May 15;187(10):1646-53 - PubMed
  93. J Clin Microbiol. 1987 Jun;25(6):1109-10 - PubMed
  94. PLoS Pathog. 2005 Dec;1(4):e45 - PubMed
  95. Vaccine. 2014 Oct 7;32(44):5787-93 - PubMed
  96. Pediatrics. 2015 Jun;135(6):990-9 - PubMed
  97. Eur J Immunol. 2004 Sep;34(9):2579-88 - PubMed
  98. J Pediatr. 2008 May;152(5):655-60, 660.e1 - PubMed
  99. Expert Rev Vaccines. 2014 Sep;13(9):1125-33 - PubMed
  100. Pediatr Infect Dis J. 2012 Jan;31(1):78-9 - PubMed
  101. Clin Infect Dis. 2000 Jul;31(1):7-14 - PubMed
  102. FEMS Immunol Med Microbiol. 2012 Apr;64(3):413-24 - PubMed
  103. Infect Immun. 2007 Apr;75(4):1713-20 - PubMed
  104. Clin Infect Dis. 2001 Jun 15;32(12):1691-7 - PubMed
  105. Clin Infect Dis. 2015 Feb 1;60(3):333-7 - PubMed
  106. JAMA. 2012 Nov 28;308(20):2126-32 - PubMed
  107. Antimicrob Agents Chemother. 1996 Apr;40(4):1041-3 - PubMed
  108. Microb Pathog. 2002 Sep;33(3):115-25 - PubMed
  109. Infect Immun. 2000 Dec;68(12):6720-8 - PubMed
  110. N Engl J Med. 1996 Feb 8;334(6):341-8 - PubMed
  111. Clin Vaccine Immunol. 2012 Nov;19(11):1879-86 - PubMed
  112. J Endotoxin Res. 2001;7(4):251-61 - PubMed
  113. Nat Rev Microbiol. 2014 Apr;12(4):274-88 - PubMed
  114. Immunol Lett. 1999 Jun 1;68(2-3):213-7 - PubMed
  115. Eur J Immunol. 1998 Jan;28(1):153-63 - PubMed
  116. J Exp Med. 2002 Jan 21;195(2):221-31 - PubMed
  117. J Clin Microbiol. 1993 Jan;31(1):50-2 - PubMed
  118. Infect Immun. 1999 Mar;67(3):1424-31 - PubMed
  119. Cell Microbiol. 2005 Apr;7(4):489-97 - PubMed
  120. Emerg Infect Dis. 2011 Apr;17(4):612-8 - PubMed
  121. Pediatrics. 2015 Jun;135(6):981-9 - PubMed
  122. Infect Immun. 1999 Aug;67(8):4064-71 - PubMed
  123. Health Policy. 2014 Mar;115(1):82-91 - PubMed
  124. Am J Obstet Gynecol. 2011 Apr;204(4):334.e1-5 - PubMed
  125. Clin Microbiol Rev. 1991 Jul;4(3):243-55 - PubMed
  126. J Infect Dis. 1990 Mar;161(3):480-6 - PubMed
  127. Infect Dis (Lond). 2015 Feb;47(2):65-8 - PubMed
  128. Vaccine. 2013 Dec 9;31(51):6087-91 - PubMed
  129. PLoS Pathog. 2013;9(4):e1003264 - PubMed
  130. J Exp Med. 1989 May 1;169(5):1519-32 - PubMed
  131. Pathog Dis. 2015 Nov;73(8):ftv071 - PubMed

Publication Types