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Scala O, Paolillo S, Formisano R, et al. Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure. Heart. 2016;102(22):1813-1819doi: 10.1136/heartjnl-2015-309215.
Scala, O., Paolillo, S., Formisano, R., Pellegrino, T., Rengo, G., Gargiulo, P., De Michele, F., Starace, A., Rapacciuolo, A., Parisi, V., Prastaro, M., Piscopo, V., Dellegrottaglie, S., Bruzzese, D., De Martino, F., Parente, A., Leosco, D., Trimarco, B., Cuocolo, A., & Perrone-Filardi, P. (2016). Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure. Heart (British Cardiac Society), 102(22), 1813-1819. https://doi.org/10.1136/heartjnl-2015-309215
Scala, Oriana, et al. "Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure." Heart (British Cardiac Society) vol. 102,22 (2016): 1813-1819. doi: https://doi.org/10.1136/heartjnl-2015-309215
Scala O, Paolillo S, Formisano R, Pellegrino T, Rengo G, Gargiulo P, De Michele F, Starace A, Rapacciuolo A, Parisi V, Prastaro M, Piscopo V, Dellegrottaglie S, Bruzzese D, De Martino F, Parente A, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P. Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure. Heart. 2016 Nov 15;102(22):1813-1819. doi: 10.1136/heartjnl-2015-309215. Epub 2016 Jun 23. PMID: 27340199.
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Heart. 2016 Nov 15;102(22):1813-1819. doi: 10.1136/heartjnl-2015-309215. Epub 2016 Jun 23.

Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure.

Heart (British Cardiac Society)

Oriana Scala, Stefania Paolillo, Roberto Formisano, Teresa Pellegrino, Giuseppe Rengo, Paola Gargiulo, Fausto De Michele, Antonio Starace, Antonio Rapacciuolo, Valentina Parisi, Maria Prastaro, Valentina Piscopo, Santo Dellegrottaglie, Dario Bruzzese, Fabiana De Martino, Antonio Parente, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi

Affiliations

  1. Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University, Naples, Italy.
  2. Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni, Italy.
  3. SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy.
  4. Department of Translational Medical Sciences, Section of Geriatrics, Federico II University, Naples, Italy.
  5. Department of Advanced Biomedical Sciences, Section of Imaging, Radiotherapy, Neuroradiology and Medical Physics, Federico II University, Naples, Italy.
  6. Institute of Biostructures and Bioimages of the National Council of Research, Naples, Italy.
  7. Division of Cardiology, "Salvatore Maugeri" Foundation-IRCCS-Institute of Telese Terme (BN), Telese Terme, Italy.
  8. Dipartimento Onco-Pneumo-Ematologia, UOC Pneumologia 1 e Fisiopatologia Respiratoria, AORN A. Cardarelli, Naples, Italy.
  9. Istituto Diagnostico Varelli, Naples, Italy.
  10. Department of Public Health, Federico II University, Naples, Italy.

PMID: 27340199 DOI: 10.1136/heartjnl-2015-309215

Abstract

OBJECTIVE: Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by

METHODS: Observational, prospective study enrolling patients with HF and reduced systolic function. Patients underwent nocturnal cardiorespiratory monitoring to assess SDB presence by apnoea/hypopnoea index (AHI), and

RESULTS: Ninety-four patients (66.1±9.8 years; left ventricular ejection fraction 32±7%) were enrolled; 72 (77%) showed SDB and, compared with non-SDB, significantly reduced early (1.67±0.22 vs 1.77±0.13; p=0.019) and late H/M ratios (1.50±0.22 vs 1.61±0.23; p=0.038). Dividing patients into two groups according to SDB severity, patients with a moderate-severe disturbance (AHI >15; n=43) showed significantly worse survival for the composite study outcome (log-rank test, p=0.001) with respect to patients with mild or no disorder (AHI ≤15; n=51). Adding SDB variables to the already known prognostic role of

CONCLUSIONS: Patients with systolic HF and SDB show more impaired cardiac adrenergic innervation assessed by

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Conflict of interest statement

Competing interests: None declared.

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