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Bharti SK, Awate S, Banerjee T, et al. Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles. Genes (Basel). 2016;7(7)doi: 10.3390/genes7070031.
Bharti, S. K., Awate, S., Banerjee, T., & Brosh, R. M. (2016). Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles. Genes, 7(7), . https://doi.org/10.3390/genes7070031
Bharti, Sanjay Kumar, et al. "Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles." Genes vol. 7,7 (2016). doi: https://doi.org/10.3390/genes7070031
Bharti SK, Awate S, Banerjee T, Brosh RM. Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles. Genes (Basel). 2016 Jul 01;7(7). doi: 10.3390/genes7070031. PMID: 27376332; PMCID: PMC4962001.
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Genes (Basel). 2016 Jul 01;7(7). doi: 10.3390/genes7070031.

Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.

Genes

Sanjay Kumar Bharti, Sanket Awate, Taraswi Banerjee, Robert M Brosh

Affiliations

  1. Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA. [email protected].
  2. Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA. [email protected].
  3. Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA. [email protected].
  4. Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA. [email protected].

PMID: 27376332 PMCID: PMC4962001 DOI: 10.3390/genes7070031

Abstract

Mounting evidence indicates that alternate DNA structures, which deviate from normal double helical DNA, form in vivo and influence cellular processes such as replication and transcription. However, our understanding of how the cellular machinery deals with unusual DNA structures such as G-quadruplexes (G4), triplexes, or hairpins is only beginning to emerge. New advances in the field implicate a direct role of the Fanconi Anemia Group J (FANCJ) helicase, which is linked to a hereditary chromosomal instability disorder and important for cancer suppression, in replication past unusual DNA obstacles. This work sets the stage for significant progress in dissecting the molecular mechanisms whereby replication perturbation by abnormal DNA structures leads to genomic instability. In this review, we focus on FANCJ and its role to enable efficient DNA replication when the fork encounters vastly abundant naturally occurring DNA obstacles, which may have implications for targeting rapidly dividing cancer cells.

Keywords: FANCJ; Fanconi Anemia; G-quadruplex; cancer; genetic diseases; genomic instability; helicase; replication; secondary DNA structure

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