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Taborelli M, Polesel J, Montella M, et al. Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy. Infect Agent Cancer. 2016;11:27doi: 10.1186/s13027-016-0073-x.
Taborelli, M., Polesel, J., Montella, M., Libra, M., Tedeschi, R., Battiston, M., Spina, M., Di Raimondo, F., Pinto, A., Crispo, A., Grimaldi, M., Franceschi, S., Dal Maso, L., & Serraino, D. (2016). Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy. Infectious agents and cancer, 1127. https://doi.org/10.1186/s13027-016-0073-x
Taborelli, Martina, et al. "Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy." Infectious agents and cancer vol. 11 (2016): 27. doi: https://doi.org/10.1186/s13027-016-0073-x
Taborelli M, Polesel J, Montella M, Libra M, Tedeschi R, Battiston M, Spina M, Di Raimondo F, Pinto A, Crispo A, Grimaldi M, Franceschi S, Dal Maso L, Serraino D. Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy. Infect Agent Cancer. 2016 Jun 23;11:27. doi: 10.1186/s13027-016-0073-x. eCollection 2016. PMID: 27340429; PMCID: PMC4918100.
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Infect Agent Cancer. 2016 Jun 23;11:27. doi: 10.1186/s13027-016-0073-x. eCollection 2016.

Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy.

Infectious agents and cancer

Martina Taborelli, Jerry Polesel, Maurizio Montella, Massimo Libra, Rosamaria Tedeschi, Monica Battiston, Michele Spina, Francesco Di Raimondo, Antonio Pinto, Anna Crispo, Maria Grimaldi, Silvia Franceschi, Luigino Dal Maso, Diego Serraino

Affiliations

  1. Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano, Italy.
  2. Unit of Epidemiology, National Cancer Institute "G. Pascale Foundation", Cappella dei Cangiani, 80131 Naples, Italy.
  3. Department of Biomedical Sciences, University of Catania, via Androne 83, 95124 Catania, Italy.
  4. Unit of Microbiology, Immunology and Virology, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano, Italy.
  5. Unit of Stem Cells Collection and Processing Unit for Cells Therapy, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano, Italy.
  6. Unit of Medical Oncology A, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano, Italy.
  7. Division of Hematology, Azienda Policlinico-OVE, University of Catania, via Citelli 6, 95124 Catania, Italy.
  8. UOSC di Ematologia Oncologica, National Cancer Institute "G. Pascale Foundation", via M. Semmola, 80131 Naples, Italy.
  9. International Agency for Research on Cancer, 150 Cours Albert Thomas, 69008 Lyon, France.

PMID: 27340429 PMCID: PMC4918100 DOI: 10.1186/s13027-016-0073-x

Abstract

BACKGROUND: Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology.

METHODS: We conducted a case-control study in Italy in 1999-2014, enrolling 571 incident, histologically confirmed NHLs and 1004 cancer-free matched controls. Study subjects provided serum for HCV and HBV testing and for HCV RNA. Odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated by logistic regression, adjusting for potential confounders.

RESULTS: Circulating HCV RNA was detected in 63 (11.1 %) NHL cases and 35 (3.5 %) controls (OR = 3.51, 95 % CI: 2.25-5.47). Chronic HBV infection (i.e., positive to HBV surface antigen - HBsAg(+)) was found in 3.7 % of cases and 1.7 % of controls (OR = 1.95, 95 % CI: 1.00-3.81); a significantly elevated OR was observed for B-cell NHL (2.11, 95 % CI: 1.07-4.15). People with serological evidence of past HCV or HBV infection, vaccination against HBV, or detectable antibodies against HBV core antigen (anti-HBc(+)) alone were not at increased NHL risk.

CONCLUSIONS: Our results support a role of chronic HCV infection in NHL in Italy and suggest an involvement of HBV infection. Associations were clearest for B-cell NHL and diffuse large B-cell lymphoma. Prevention and treatment of HCV and HBV infection may diminish NHL incidence, notably in areas with high prevalence of hepatitis viruses infection.

Keywords: Case-control study; Hepatitis B virus; Hepatitis C virus; Non-Hodgkin lymphoma

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