Display options
Cite
Madej M, Nowak B, Świerkot J, et al. Cytokine profiles in axial spondyloarthritis. Reumatologia. 2015;53(1):9-13doi: 10.5114/reum.2015.50551.
Madej, M., Nowak, B., Świerkot, J., Sokolik, R., Chlebicki, A., Korman, L., Woytala, P., Lubiński, �. �., & Wiland, P. (2015). Cytokine profiles in axial spondyloarthritis. Reumatologia, 53(1), 9-13. https://doi.org/10.5114/reum.2015.50551
Madej, Marta, et al. "Cytokine profiles in axial spondyloarthritis." Reumatologia vol. 53,1 (2015): 9-13. doi: https://doi.org/10.5114/reum.2015.50551
Madej M, Nowak B, Świerkot J, Sokolik R, Chlebicki A, Korman L, Woytala P, Lubiński Ł, Wiland P. Cytokine profiles in axial spondyloarthritis. Reumatologia. 2015;53(1):9-13. doi: 10.5114/reum.2015.50551. Epub 2015 Apr 09. PMID: 27407219; PMCID: PMC4847310.
Copy Download .nbib Format: NLM
Share it on

Reumatologia. 2015;53(1):9-13. doi: 10.5114/reum.2015.50551. Epub 2015 Apr 09.

Cytokine profiles in axial spondyloarthritis.

Reumatologia

Marta Madej, Beata Nowak, Jerzy Świerkot, Renata Sokolik, Arkadiusz Chlebicki, Lucyna Korman, Patryk Woytala, Łukasz Lubiński, Piotr Wiland

Affiliations

  1. Chair and Department of Rheumatology and Internal Diseases, Wroclaw Medical University, Wroclaw, Poland.
  2. Chair and Department of Pharmacology, Wroclaw Medical University, Wroclaw, Poland.
  3. Department of Rheumatology and Internal Diseases, University Hospital in Wroclaw, Wroclaw, Poland.

PMID: 27407219 PMCID: PMC4847310 DOI: 10.5114/reum.2015.50551

Abstract

OBJECTIVES: Current studies concentrate on the cytokine network and its role in the pathogenesis of spondyloarthritis (SpA). In this study, we analyzed whether the serum cytokine profile (interleukins: IL-10, IL-11, IL-12, IL-15, IL-17, IL-23 and IL-33) correlates with demographic data, clinical manifestations, disease activity and treatment outcome in a group of patients with axial spondyloarthritis.

MATERIAL AND METHODS: Forty-nine patients with an established diagnosis of axial spondyloarthritis (aSpA) and 19 healthy volunteers as controls were enrolled in the study. Clinical evaluation included patient's medical history, 44 joint count, back pain intensity and global disease activity in the preceding week (VAS), the duration of morning stiffness and blood tests. Disease activity was assessed using BASDAI and ASDAS-CRP. Serum concentration of IL-10, IL-11, IL-12, IL-15, IL-17, IL-23 and IL-33 was determined.

RESULTS: In patients with aSpA, elevated serum concentration of IL-10, IL-15, IL-17 and IL-23 was detected. In the aSpA group we detected higher values of serum concentration of IL-23 and IL-33 in the subgroup with anterior uveitis (83.1 ±184.0 pg/ml vs. 14.0 ±17.1 pg/ml, p < 0.0001 and 45.5 ±71.9 pg/ml vs. 18.4 ±14.3 pg/ml, p < 0.0001, respectively). Additionally, in the subgroup with peripheral arthritis, elevation of serum concentration of IL-12 (249.3 ±246.9 pg/ml vs. 99.9 ±105.9 pg/ml, p = 0.0001) was detected. Patients with preradiological SpA had higher serum concentration of IL-17 than patients with established diagnosis of AS (6.37 ±8.50 pg/ml vs. 2.04 ±2.98 pg/ml, p = 0.0295). No differences in serum concentration of analyzed cytokines were found between the subgroup with low to moderate disease activity and the subgroup with high to very high disease activity.

CONCLUSIONS: We report that in aSpA patients, compared to controls, elevated serum concentrations of IL-10, IL-15, IL-17 and IL-23 were observed. Some cytokines may predispose to a more severe course of aSpA.

Keywords: cytokines; spondyloarthritis; uveitis

References

  1. Postepy Dermatol Alergol. 2014 Aug;31(4):256-61 - PubMed
  2. J Investig Med. 2013 Jun;61(5):848-51 - PubMed
  3. J Interferon Cytokine Res. 2011 Dec;31(12):927-40 - PubMed
  4. J Rheumatol. 1994 Dec;21(12):2281-5 - PubMed
  5. Curr Opin Rheumatol. 2014 Jul;26(4):361-70 - PubMed
  6. Ann Rheum Dis. 2009 Jun;68(6):777-83 - PubMed
  7. Ann Rheum Dis. 2011 Jan;70(1):25-31 - PubMed
  8. Rev Bras Reumatol. 2012 Aug;52(4):536-44 - PubMed
  9. Eur J Immunol. 2014 Nov;44(11):3320-9 - PubMed
  10. Arthritis Rheum. 2011 Dec;63(12):3807-17 - PubMed
  11. Arthritis Rheum. 1984 Apr;27(4):361-8 - PubMed
  12. Arthritis Res Ther. 2012 May 28;14(3):R127 - PubMed
  13. Clin Rheumatol. 2001;20(3):201-6 - PubMed
  14. Mol Immunol. 2014 Jan;57(1):28-37 - PubMed
  15. Ann Rheum Dis. 2009 Jan;68(1):18-24 - PubMed
  16. Arthritis Rheum. 2013 Jun;65(6):1522-9 - PubMed
  17. Ann Rheum Dis. 2011 Aug;70(8):1369-74 - PubMed
  18. Clin Rheumatol. 2011 Feb;30(2):269-73 - PubMed
  19. Arthritis Rheum. 2011 Dec;63(12):3668-71 - PubMed
  20. Scand J Rheumatol. 2013;42(3):226-31 - PubMed
  21. Arthritis Rheum. 2009 Sep;60(9):2633-43 - PubMed
  22. PLoS One. 2013 Jun 28;8(6):e67505 - PubMed
  23. Arthritis Res Ther. 2008;10(5):R122 - PubMed
  24. Ann Rheum Dis. 2009 Dec;68(12):1811-8 - PubMed
  25. Ann Rheum Dis. 2010 Mar;69(3):618-23 - PubMed
  26. Clin Exp Rheumatol. 2011 Sep-Oct;29(5):828-34 - PubMed
  27. Clin Rheumatol. 2009 Feb;28(2):187-90 - PubMed
  28. J Rheumatol. 1994 Dec;21(12):2286-91 - PubMed

Publication Types