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Maddila SN, Maddila S, van Zyl WE, et al. Ceria-Vanadia/Silica-Catalyzed Cascade for C-C and C-O Bond Activation: Green One-Pot Synthesis of 2-Amino-3-cyano-4H-pyrans. ChemistryOpen. 2015;5(1):38-42doi: 10.1002/open.201500159.
Maddila, S. N., Maddila, S., van Zyl, W. E., & Jonnalagadda, S. B. (2016). Ceria-Vanadia/Silica-Catalyzed Cascade for C-C and C-O Bond Activation: Green One-Pot Synthesis of 2-Amino-3-cyano-4H-pyrans. ChemistryOpen, 5(1), 38-42. https://doi.org/10.1002/open.201500159
Maddila, Surya Narayana, et al. "Ceria-Vanadia/Silica-Catalyzed Cascade for C-C and C-O Bond Activation: Green One-Pot Synthesis of 2-Amino-3-cyano-4H-pyrans." ChemistryOpen vol. 5,1 (2016): 38-42. doi: https://doi.org/10.1002/open.201500159
Maddila SN, Maddila S, van Zyl WE, Jonnalagadda SB. Ceria-Vanadia/Silica-Catalyzed Cascade for C-C and C-O Bond Activation: Green One-Pot Synthesis of 2-Amino-3-cyano-4H-pyrans. ChemistryOpen. 2015 Aug 19;5(1):38-42. doi: 10.1002/open.201500159. eCollection 2016 Feb. PMID: 27308209; PMCID: PMC4906492.
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ChemistryOpen. 2015 Aug 19;5(1):38-42. doi: 10.1002/open.201500159. eCollection 2016 Feb.

Ceria-Vanadia/Silica-Catalyzed Cascade for C-C and C-O Bond Activation: Green One-Pot Synthesis of 2-Amino-3-cyano-4H-pyrans.

ChemistryOpen

Surya Narayana Maddila, Suresh Maddila, Werner E van Zyl, Sreekantha B Jonnalagadda

Affiliations

  1. School of Chemistry & Physics University of KwaZulu-Natal Westville Campus Chiltern Hills Durban 4000 South Africa.

PMID: 27308209 PMCID: PMC4906492 DOI: 10.1002/open.201500159

Abstract

We designed a ceria-vanadia/silica (Ce-V/SiO2) heterogeneous catalyst and used it for the green and efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives. The green reaction was a multicomponent one-pot condensation of 5,5-dimethylcyclohexane-1,3-dione, aromatic aldehyde, and malononitrile in an eco-compatible solvent (ethanol). The catalyst was synthesized and fully characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Brunauer-Emmett-Teller (BET) surface area analysis. The reported procedure offers a number of advantages including decreased reaction times, mild conditions, high yields, operational simplicity, and environmentally benign and simple work-up procedures. Furthermore, the catalyst is economical, fully recyclable, and reusable for over five runs while preserving its high activity. The synthesized 2-amino-3-cyano-4H-pyran products can later be used for pharmaceutical purposes.

Keywords: 4H-pyrans; ceria–vandia/silica (Ce–V/SiO2); green chemistry; heterogeneous catalysts; one-pot multicomponent reactions; recyclable

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