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Karali E, Bellou S, Stellas D, et al. VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis. Mol Cell Oncol. 2014;1(3):e964024doi: 10.4161/23723548.2014.964024.
Karali, E., Bellou, S., Stellas, D., Klinakis, A., Murphy, C., & Fotsis, T. (2014). VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis. Molecular & cellular oncology, 1(3), e964024. https://doi.org/10.4161/23723548.2014.964024
Karali, Evdoxia, et al. "VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis." Molecular & cellular oncology vol. 1,3 (2014): e964024. doi: https://doi.org/10.4161/23723548.2014.964024
Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T. VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis. Mol Cell Oncol. 2014 Dec 23;1(3):e964024. doi: 10.4161/23723548.2014.964024. eCollection 2014. PMID: 27308350; PMCID: PMC4904886.
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Mol Cell Oncol. 2014 Dec 23;1(3):e964024. doi: 10.4161/23723548.2014.964024. eCollection 2014.

VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis.

Molecular & cellular oncology

Evdoxia Karali, Sofia Bellou, Dimitris Stellas, Apostolos Klinakis, Carol Murphy, Theodore Fotsis

Affiliations

  1. Foundation of Research and Technology-Hellas; Institute of Molecular Biology & Biotechnology - Department of Biomedical Research; Ioannina, Greece; Laboratory of Biological Chemistry; Medical School; University of Ioannina; Ioannina, Greece.
  2. Foundation of Research and Technology-Hellas; Institute of Molecular Biology & Biotechnology - Department of Biomedical Research; Ioannina, Greece; Department of Informatics and Telecommunications Engineering; University of Western Macedonia; Kozani, Greece.
  3. Department of Cancer Biology; Biomedical Research Foundation of the Academy of Athens ; Athens, Greece.
  4. Foundation of Research and Technology-Hellas; Institute of Molecular Biology & Biotechnology - Department of Biomedical Research ; Ioannina, Greece.

PMID: 27308350 PMCID: PMC4904886 DOI: 10.4161/23723548.2014.964024

Abstract

Vascular endothelial growth factor (VEGF) activates unfolded protein response sensors in the endoplasmic reticulum through phospholipase C gamma (PLCγ)-mediated crosstalk with mammalian target of rapamycin complex 1 (mTORC1). Activation of transcription factor 6 (ATF6) and protein kinase RNA-like endoplasmic reticulum kinase (PERK) activate mTORC2, ensuring maximal endothelial cell survival and angiogenic activity through phosphorylation of AKT on Ser473. As mTORC1 is a metabolic sensor, metabolic signals may be integrated with signals from VEGF in the regulation of angiogenesis.

Keywords: AKT; ATF6; CHOP; IRE1α; PERK; PLCγ; VEGF; angiogenesis; apoptosis; mTORC1; mTORC2; survival; unfolded protein response

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