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Harder L, Puller AC, Horstmann MA. ZNF423: Transcriptional modulation in development and cancer. Mol Cell Oncol. 2014;1(3):e969655doi: 10.4161/23723548.2014.969655.
Harder, L., Puller, A. C., & Horstmann, M. A. (2014). ZNF423: Transcriptional modulation in development and cancer. Molecular & cellular oncology, 1(3), e969655. https://doi.org/10.4161/23723548.2014.969655
Harder, Lena, et al. "ZNF423: Transcriptional modulation in development and cancer." Molecular & cellular oncology vol. 1,3 (2014): e969655. doi: https://doi.org/10.4161/23723548.2014.969655
Harder L, Puller AC, Horstmann MA. ZNF423: Transcriptional modulation in development and cancer. Mol Cell Oncol. 2014 Dec 23;1(3):e969655. doi: 10.4161/23723548.2014.969655. eCollection 2014. PMID: 27308357; PMCID: PMC4905017.
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Mol Cell Oncol. 2014 Dec 23;1(3):e969655. doi: 10.4161/23723548.2014.969655. eCollection 2014.

ZNF423: Transcriptional modulation in development and cancer.

Molecular & cellular oncology

Lena Harder, Ann-Christin Puller, Martin A Horstmann

Affiliations

  1. Research Institute Children's Cancer Center Hamburg and Clinic of Pediatric Hematology and Oncology; University Medical Center Hamburg-Eppendorf ; Hamburg, Germany.

PMID: 27308357 PMCID: PMC4905017 DOI: 10.4161/23723548.2014.969655

Abstract

Krüppel-like zinc finger proteins are versatile players in biology that have been implicated in mammalian development and disease. Among these proteins, ZNF423 and its mouse ortholog Zfp423 were initially implicated in midline patterning of the central nervous system but have emerged as critical transcriptional modulators in cancer. Epigenetically uncurbed ZNF423 interferes with lymphopoiesis by sequestration of the essential early B-cell factor 1 (EBF1) causing B-cell maturation arrest, a hallmark of acute lymphoblastic leukemia. Conversely, its presence in neuroblastoma, a primitive neuroectodermal tumor of childhood, allows retinoic acid-induced differentiation and is associated with a favorable outcome of neuroblastoma patients. Such opposing effects may be explained by the cellular context, but also by the multifunctionality of ZNF423 that is mediated by 30 zinc fingers forming various functional domains. This review summarizes current knowledge of ZNF423, focusing on its role in development and cancer.

Keywords: BMP2; EBF1; ZNF423; Zfp423; acute lymphoblastic leukemia; adipogenesis; neuroblastoma; neurogenesis

References

  1. Oncogene. 2003 Oct 20;22(47):7305-15 - PubMed
  2. Blood. 2013 Dec 5;122(24):3899-907 - PubMed
  3. Nature. 1995 Jul 20;376(6537):263-7 - PubMed
  4. Best Pract Res Clin Haematol. 2011 Dec;24(4):489-503 - PubMed
  5. Cell. 2012 Aug 3;150(3):533-48 - PubMed
  6. J Biol Chem. 2006 Aug 18;281(33):23922-31 - PubMed
  7. Leukemia. 2007 Jun;21(6):1258-66 - PubMed
  8. Nat Rev Cancer. 2001 Dec;1(3):181-93 - PubMed
  9. Stem Cells. 2004;22(4):457-74 - PubMed
  10. Blood. 2003 Mar 1;101(5):1934-40 - PubMed
  11. Neuron. 2007 May 24;54(4):547-57 - PubMed
  12. PLoS Biol. 2012;10(11):e1001433 - PubMed
  13. PLoS One. 2013 Jun 06;8(6):e66514 - PubMed
  14. Cell. 2010 Jul 23;142(2):218-29 - PubMed
  15. Biochem Biophys Res Commun. 2003 Nov 21;311(3):702-7 - PubMed
  16. Leuk Lymphoma. 2003 Nov;44(11):1855-64 - PubMed
  17. Nat Rev Genet. 2002 Jun;3(6):415-28 - PubMed
  18. Vitam Horm. 2011;86:103-26 - PubMed
  19. J Biol Chem. 2010 Oct 1;285(40):30814-24 - PubMed
  20. Nature. 1993 Jul 8;364(6433):121-6 - PubMed
  21. Oncogene. 2007 Aug 13;26(37):5433-8 - PubMed
  22. Curr Opin Immunol. 2000 Jun;12 (3):276-81 - PubMed
  23. Genes Dev. 2000 Mar 15;14(6):627-44 - PubMed
  24. Nature. 1995 Oct 5;377(6548):397-404 - PubMed
  25. Nucleic Acids Res. 2011 Nov 1;39(20):8712-27 - PubMed
  26. Cytokine Growth Factor Rev. 1998 Mar;9(1):49-61 - PubMed
  27. Blood. 2009 May 7;113(19):4702-10 - PubMed
  28. Nature. 2003 Oct 23;425(6960):836-41 - PubMed
  29. Mutat Res. 2008 Jul-Aug;659(1-2):40-8 - PubMed
  30. Blood. 2004 Mar 15;103(6):2062-70 - PubMed
  31. Cancer Cell. 2009 Apr 7;15(4):249-51 - PubMed
  32. J Exp Med. 2013 Oct 21;210(11):2289-304 - PubMed
  33. Mol Biol Cell. 2000 Feb;11(2):555-65 - PubMed
  34. Annu Rev Biochem. 1998;67:753-91 - PubMed
  35. Annu Rev Biochem. 1995;64:345-73 - PubMed
  36. Nature. 1995 Oct 5;377(6548):454-7 - PubMed
  37. Cell. 2000 Jan 21;100(2):229-40 - PubMed
  38. J Neurosci. 1997 Jun 1;17(11):4159-69 - PubMed
  39. Biochim Biophys Acta. 2013 Dec;1833(12):3218-27 - PubMed
  40. Cancer Cell. 2009 Apr 7;15(4):328-40 - PubMed
  41. Diabetes. 2013 Nov;62(11):3727-35 - PubMed
  42. Nat Rev Cancer. 2003 Mar;3(3):203-16 - PubMed
  43. Oncogene. 2004 Apr 8;23(15):2727-31 - PubMed
  44. Mol Cell Biol. 1998 Nov;18(11):6447-56 - PubMed
  45. J Biol Chem. 2006 Feb 24;281(8):5277-87 - PubMed
  46. Nature. 2004 May 27;429(6990):457-63 - PubMed
  47. N Engl J Med. 2004 Apr 8;350(15):1535-48 - PubMed
  48. Mol Cell Biol. 2014 Aug;34(16):3076-85 - PubMed
  49. Genes Dev. 1996 Jul 1;10(13):1580-94 - PubMed
  50. FASEB J. 1996 Jul;10(9):940-54 - PubMed
  51. EMBO J. 1991 Nov;10(11):3409-17 - PubMed
  52. Curr Opin Immunol. 2007 Apr;19(2):137-42 - PubMed
  53. J Biol Chem. 2004 Dec 31;279(53):55017-23 - PubMed
  54. Curr Opin Immunol. 2010 Apr;22(2):161-7 - PubMed
  55. Cell. 2007 Feb 23;128(4):669-81 - PubMed
  56. Mol Cell Biol. 2006 Sep;26(18):6913-22 - PubMed
  57. J Clin Oncol. 2005 Sep 10;23(26):6306-15 - PubMed
  58. Epigenetics. 2009 Oct 1;4(7):462-8 - PubMed
  59. J Neurosci. 1997 Jun 1;17(11):4149-58 - PubMed
  60. J Pathol. 2013 Oct;231(2):158-67 - PubMed
  61. Nature. 2010 Mar 25;464(7288):619-23 - PubMed
  62. Dev Biol. 2007 Jul 1;307(1):43-52 - PubMed
  63. Blood. 2013 Nov 28;122(23):3767-77 - PubMed
  64. Nature. 2007 Apr 12;446(7137):758-64 - PubMed
  65. J Exp Med. 1999 Apr 5;189(7):1139-48 - PubMed
  66. Development. 2004 Mar;131(6):1377-88 - PubMed
  67. Nat Immunol. 2001 Feb;2(2):142-3 - PubMed
  68. Nature. 2008 Aug 7;454(7205):766-70 - PubMed

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