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Ségal-Bendirdjian E, Tschan MP, Reiffers J, et al. Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells. Mol Cell Oncol. 2014;1(4):e970066doi: 10.4161/23723548.2014.970066.
Ségal-Bendirdjian, E., Tschan, M. P., Reiffers, J., & Djavaheri-Mergny, M. (2014). Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells. Molecular & cellular oncology, 1(4), e970066. https://doi.org/10.4161/23723548.2014.970066
Ségal-Bendirdjian, Evelyne, et al. "Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells." Molecular & cellular oncology vol. 1,4 (2014): e970066. doi: https://doi.org/10.4161/23723548.2014.970066
Ségal-Bendirdjian E, Tschan MP, Reiffers J, Djavaheri-Mergny M. Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells. Mol Cell Oncol. 2014 Dec 31;1(4):e970066. doi: 10.4161/23723548.2014.970066. eCollection 2014. PMID: 27308379; PMCID: PMC4905221.
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Mol Cell Oncol. 2014 Dec 31;1(4):e970066. doi: 10.4161/23723548.2014.970066. eCollection 2014.

Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells.

Molecular & cellular oncology

Evelyne Ségal-Bendirdjian, Mario P Tschan, Josy Reiffers, Mojgan Djavaheri-Mergny

Affiliations

  1. INSERM UMR-S 1007; Cellular Homeostasis and Cancer; Université Paris Descartes; Sorbonne Paris Cite ; Paris, France.
  2. Division of Experimental Pathology; Institute of Pathology; University of Bern ; Bern, Switzerland.
  3. INSERM U916 VINCO; Institut Bergonié; Bordeaux, France; University of Bordeaux; Bordeaux, France.

PMID: 27308379 PMCID: PMC4905221 DOI: 10.4161/23723548.2014.970066

Abstract

p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML) cells. This response reduces levels of ubiquitinated protein aggregates in mature cells and protects these cells against ATRA treatment. Thus, p62 confers a survival advantage to mature AML cells.

Keywords: SQSTM1/p62; autophagy; cell survival; differentiation; leukemia

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