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Cianfanelli V, Nazio F, Cecconi F. Connecting autophagy: AMBRA1 and its network of regulation. Mol Cell Oncol. 2015;2(1):e970059doi: 10.4161/23723548.2014.970059.
Cianfanelli, V., Nazio, F., & Cecconi, F. (2015). Connecting autophagy: AMBRA1 and its network of regulation. Molecular & cellular oncology, 2(1), e970059. https://doi.org/10.4161/23723548.2014.970059
Cianfanelli, Valentina, et al. "Connecting autophagy: AMBRA1 and its network of regulation." Molecular & cellular oncology vol. 2,1 (2015): e970059. doi: https://doi.org/10.4161/23723548.2014.970059
Cianfanelli V, Nazio F, Cecconi F. Connecting autophagy: AMBRA1 and its network of regulation. Mol Cell Oncol. 2015 Feb 24;2(1):e970059. doi: 10.4161/23723548.2014.970059. eCollection 2015. PMID: 27308402; PMCID: PMC4905234.
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Mol Cell Oncol. 2015 Feb 24;2(1):e970059. doi: 10.4161/23723548.2014.970059. eCollection 2015.

Connecting autophagy: AMBRA1 and its network of regulation.

Molecular & cellular oncology

Valentina Cianfanelli, Francesca Nazio, Francesco Cecconi

Affiliations

  1. Unit of Cell Stress and Survival; Danish Cancer Society Research Center ; Copenhagen, Denmark.
  2. IRCCS Fondazione Santa Lucia ; Rome, Italy.
  3. Unit of Cell Stress and Survival; Danish Cancer Society Research Center; Copenhagen, Denmark; IRCCS Fondazione Santa Lucia; Rome, Italy; Department of Biology; University of Rome Tor Vergata; Rome, Italy.

PMID: 27308402 PMCID: PMC4905234 DOI: 10.4161/23723548.2014.970059

Abstract

During autophagy, a double-membraned vesicle called the autophagosome is responsible for the degradation of long-lived proteins and damaged/old organelles, thus contributing to the maintenance of cellular homeostasis. Physiological stimuli and stressors enhance autophagy in order to accomplish important processes such as cell differentiation or as a cytoprotective response. In line with this, numerous studies have demonstrated the relevance of proper autophagy regulation to health. Autophagy defects are associated with the insurgence of neurological/neurodegenerative diseases and cancer. Moreover, the autophagy pathway is often potentiated in cancer cells to increase cell survival. Increased knowledge of the molecular mechanisms underlying autophagy regulation and their interplay with other cellular pathways would provide advances in cancer treatment. In this context, post-translational modifications, protein-protein interactions, and regulative feedback loops offer promising insights. In this review, we focus on AMBRA1, a proautophagic protein that was recently demonstrated to participate in numerous crucial regulative mechanisms of the autophagy process.

Keywords: apoptosis; cancer; cell survival; embryonic development; mitophagy

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