Display options
Cite
Di Virgilio F. P2RX7: A receptor with a split personality in inflammation and cancer. Mol Cell Oncol. 2015;3(2):e1010937doi: 10.1080/23723556.2015.1010937.
Di Virgilio, F. (2016). P2RX7: A receptor with a split personality in inflammation and cancer. Molecular & cellular oncology, 3(2), e1010937. https://doi.org/10.1080/23723556.2015.1010937
Di Virgilio, Francesco. "P2RX7: A receptor with a split personality in inflammation and cancer." Molecular & cellular oncology vol. 3,2 (2016): e1010937. doi: https://doi.org/10.1080/23723556.2015.1010937
Di Virgilio F. P2RX7: A receptor with a split personality in inflammation and cancer. Mol Cell Oncol. 2015 Feb 03;3(2):e1010937. doi: 10.1080/23723556.2015.1010937. eCollection 2016 Mar. PMID: 27308580; PMCID: PMC4905332.
Copy Download .nbib Format: NLM
Share it on

Mol Cell Oncol. 2015 Feb 03;3(2):e1010937. doi: 10.1080/23723556.2015.1010937. eCollection 2016 Mar.

P2RX7: A receptor with a split personality in inflammation and cancer.

Molecular & cellular oncology

Francesco Di Virgilio

Affiliations

  1. Department of Morphology; Surgery and Experimental Medicine; Section of Pathology; Oncology and Experimental Biology; University of Ferrara ; Ferrara, Italy.

PMID: 27308580 PMCID: PMC4905332 DOI: 10.1080/23723556.2015.1010937

Abstract

P2X7 (also known as P2RX7) is a plasma membrane receptor for extracellular ATP that is expressed at a high level by immune and tumor cells. Previous data showed that increased P2rx7 expression by tumor cells accelerates tumor progression. We have now looked at the other side of the relationship by investigating the effect of a lack of host P2rx7 expression on tumor growth. Our novel observations highlight a surprising role of host P2rx7 in restraining tumor progression.

Keywords: extracellular ATP; immunity; purinergic receptors; tumors

References

  1. Cancer Res. 2012 Jun 15;72(12):2957-69 - PubMed
  2. Cancer Res. 2015 Feb 15;75(4):635-44 - PubMed
  3. Nat Med. 2010 Dec;16(12):1434-8 - PubMed
  4. Cancer Res. 2015 Mar 1;75(5):835-45 - PubMed
  5. Cell Death Dis. 2014 Mar 20;5:e1135 - PubMed
  6. Cancer Res. 2012 Nov 1;72(21):5441-7 - PubMed
  7. Oncogene. 2011 May 5;30(18):2108-22 - PubMed
  8. Exp Physiol. 2014 Jan;99(1):16-34 - PubMed
  9. J Immunol. 1989 Sep 15;143(6):1955-60 - PubMed
  10. J Auton Nerv Syst. 2000 Jul 3;81(1-3):59-63 - PubMed

Publication Types