Mol Cell Oncol. 2015 Feb 26;3(2):e1019974. doi: 10.1080/23723556.2015.1019974. eCollection 2016 Mar.

Mirror image phosphoinositides regulate autophagy.

Molecular & cellular oncology

Mariella Vicinanza, David C Rubinsztein

PMID: 27308581 PMCID: PMC4905334 DOI: 10.1080/23723556.2015.1019974

Abstract

Autophagosome formation is stimulated by canonical VPS34-dependent formation of phosphatidylinositol 3-phosphate [PI(3)P], which recruits effectors such as WIPI2. However, non-canonical VPS34-independent autophagy has also been proposed. We recently described that PI(5)P regulates autophagosome biogenesis, recruits WIPI2, and rescues autophagy in VPS34-inactivated cells. These alternative autophagy-initiating pathways reveal new druggable targets for treating neurodegeneration and cancer.

Keywords: autophagym, phosphoinositide, VPS34, PI(5)P

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