Display options
Cite
Saha AS, Islam MF, Bhattacharya S, et al. Clinical Presentation of Inadvertent Intrathecal Vincristine Masquerading Guillain-Barre Syndrome. Indian J Hematol Blood Transfus. 2016;32:59-61doi: 10.1007/s12288-016-0666-y.
Saha, A. S., Islam, M. F., Bhattacharya, S., & Giri, P. P. (2016). Clinical Presentation of Inadvertent Intrathecal Vincristine Masquerading Guillain-Barre Syndrome. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 3259-61. https://doi.org/10.1007/s12288-016-0666-y
Saha, Agni Sekhar, et al. "Clinical Presentation of Inadvertent Intrathecal Vincristine Masquerading Guillain-Barre Syndrome." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion vol. 32 (2016): 59-61. doi: https://doi.org/10.1007/s12288-016-0666-y
Saha AS, Islam MF, Bhattacharya S, Giri PP. Clinical Presentation of Inadvertent Intrathecal Vincristine Masquerading Guillain-Barre Syndrome. Indian J Hematol Blood Transfus. 2016 Jun;32:59-61. doi: 10.1007/s12288-016-0666-y. Epub 2016 Mar 12. PMID: 27408356; PMCID: PMC4925561.
Copy Download .nbib Format: NLM
Share it on

Indian J Hematol Blood Transfus. 2016 Jun;32:59-61. doi: 10.1007/s12288-016-0666-y. Epub 2016 Mar 12.

Clinical Presentation of Inadvertent Intrathecal Vincristine Masquerading Guillain-Barre Syndrome.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Agni Sekhar Saha, Md Fekarul Islam, Sukanta Bhattacharya, Prabhas Prasun Giri

Affiliations

  1. Fortis Hospital, 30/H Mahendra Roy Lane, Kolkata, West Bengal 700046 India.
  2. Institute of Child Health, Kolkata, India.

PMID: 27408356 PMCID: PMC4925561 DOI: 10.1007/s12288-016-0666-y

Abstract

Vincristine, a potent chemotherapeutic agent, is highly neurotoxic. If given intrathecally by accident it is almost always fatal. We are reporting a 6 year old girl with acute lymphoblastic leukaemia in complete remission, who was given inadvertent intrathecal Vincristine instead of Methotrexate. She developed gradually progressive quadriplegia and respiratory paralysis requiring prolonged mechanical ventilation, initially mimicking Guillain-Barre Syndrome, both clinically and electro-physiologically. She also developed progressive encephalopathy. The clinical deterioration subsequently plateaued without any significant improvement and after more than 5 months, she finally expired.

Keywords: ALL; GB syndrome; Intrathecal vincristine

References

  1. J Toxicol Clin Toxicol. 2002;40(5):557-61 - PubMed
  2. Clin J Oncol Nurs. 2006 Apr;10(2):271-3 - PubMed
  3. J Neurosurg Spine. 2007 Mar;6(3):280-3 - PubMed
  4. Indian J Pediatr. 2010 Jan;77(1):97-100 - PubMed

Publication Types