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Nowinski SM, Solmonson A, Mills EM. Chewing the fat for Akt1 inhibition and oncosuppression. Mol Cell Oncol. 2015;3(2):e1102795doi: 10.1080/23723556.2015.1102795.
Nowinski, S. M., Solmonson, A., & Mills, E. M. (2016). Chewing the fat for Akt1 inhibition and oncosuppression. Molecular & cellular oncology, 3(2), e1102795. https://doi.org/10.1080/23723556.2015.1102795
Nowinski, Sara M, et al. "Chewing the fat for Akt1 inhibition and oncosuppression." Molecular & cellular oncology vol. 3,2 (2016): e1102795. doi: https://doi.org/10.1080/23723556.2015.1102795
Nowinski SM, Solmonson A, Mills EM. Chewing the fat for Akt1 inhibition and oncosuppression. Mol Cell Oncol. 2015 Nov 09;3(2):e1102795. doi: 10.1080/23723556.2015.1102795. eCollection 2016 Mar. PMID: 27308618; PMCID: PMC4905408.
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Mol Cell Oncol. 2015 Nov 09;3(2):e1102795. doi: 10.1080/23723556.2015.1102795. eCollection 2016 Mar.

Chewing the fat for Akt1 inhibition and oncosuppression.

Molecular & cellular oncology

Sara M Nowinski, Ashley Solmonson, Edward M Mills

Affiliations

  1. Department of Biochemistry, University of Utah School of Medicine , Salt Lake City, UT, USA.
  2. Division of Pharmacology and Toxicology, College of Pharmacy and; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.

PMID: 27308618 PMCID: PMC4905408 DOI: 10.1080/23723556.2015.1102795

Abstract

The catabolic and energy-dissipating actions of mitochondrial uncoupling proteins (UCPs) conflict with many of the bioenergetic hallmarks of malignancy. We have recently demonstrated that overexpression of mitochondrial uncoupling protein 3 (Ucp3) in the basal epidermis impedes skin tumorigenesis through a novel pathway of thymoma viral proto-oncogene 1 (Akt1) inhibition via increased mitochondrial lipid catabolism.

Keywords: Akt; UCP3; keratinocytes; lipid catabolism; metabolomics; mitochondria; skin cancer; uncoupling; uncoupling proteins

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