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Tse G, Lai ET, Lee AP, et al. Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart. Front Physiol. 2016;7:230doi: 10.3389/fphys.2016.00230.
Tse, G., Lai, E. T., Lee, A. P., Yan, B. P., & Wong, S. H. (2016). Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart. Frontiers in physiology, 7230. https://doi.org/10.3389/fphys.2016.00230
Tse, Gary, et al. "Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart." Frontiers in physiology vol. 7 (2016): 230. doi: https://doi.org/10.3389/fphys.2016.00230
Tse G, Lai ET, Lee AP, Yan BP, Wong SH. Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart. Front Physiol. 2016 Jun 14;7:230. doi: 10.3389/fphys.2016.00230. eCollection 2016. PMID: 27378939; PMCID: PMC4906021.
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Front Physiol. 2016 Jun 14;7:230. doi: 10.3389/fphys.2016.00230. eCollection 2016.

Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart.

Frontiers in physiology

Gary Tse, Eric T H Lai, Alex P W Lee, Bryan P Yan, Sunny H Wong

Affiliations

  1. Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, The University of Hong KongHong Kong, China; Department of Medicine and Therapeutics, The Chinese University of Hong KongHong Kong, China.
  2. Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong Hong Kong, China.
  3. Department of Medicine and Therapeutics, The Chinese University of Hong Kong Hong Kong, China.
  4. Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong Hong Kong, China.

PMID: 27378939 PMCID: PMC4906021 DOI: 10.3389/fphys.2016.00230

Abstract

Disruptions in the orderly activation and recovery of electrical excitation traveling through the heart and the gastrointestinal (GI) tract can lead to arrhythmogenesis. For example, cardiac arrhythmias predispose to thromboembolic events resulting in cerebrovascular accidents and myocardial infarction, and to sudden cardiac death. By contrast, arrhythmias in the GI tract are usually not life-threatening and much less well characterized. However, they have been implicated in the pathogenesis of a number of GI motility disorders, including gastroparesis, dyspepsia, irritable bowel syndrome, mesenteric ischaemia, Hirschsprung disease, slow transit constipation, all of which are associated with significant morbidity. Both cardiac and gastrointestinal arrhythmias can broadly be divided into non-reentrant and reentrant activity. The aim of this paper is to compare and contrast the mechanisms underlying arrhythmogenesis in both systems to provide insight into the pathogenesis of GI motility disorders and potential molecular targets for future therapy.

Keywords: arrhythmia; cardiac electrophysiology; electrical excitation; focal activity; gastrointestinal electrophysiology; reentry

References

  1. J Physiol. 1999 Jun 1;517 ( Pt 2):563-73 - PubMed
  2. Circ Res. 1999 Jul 23;85(2):174-81 - PubMed
  3. Am J Physiol. 1999 Aug;277(2):G409-23 - PubMed
  4. Am J Physiol. 1999 Nov;277(5):G993-9 - PubMed
  5. Circ Res. 2000 Dec 8;87(12):1103-7 - PubMed
  6. Gastroenterology. 2000 Dec;119(6):1590-9 - PubMed
  7. Circulation. 2001 Jan 16;103(2):196-200 - PubMed
  8. J Physiol. 2001 Mar 15;531(Pt 3):827-33 - PubMed
  9. News Physiol Sci. 2001 Jun;16:138-44 - PubMed
  10. Circ Res. 2002 Jan 11;90(1):14-7 - PubMed
  11. Nature. 2002 Jan 10;415(6868):198-205 - PubMed
  12. Recent Adv Stud Cardiac Struct Metab. 1975;5:303-8 - PubMed
  13. Gut. 2002 Oct;51(4):496-501 - PubMed
  14. J Pediatr Gastroenterol Nutr. 2003 Apr;36(4):492-7 - PubMed
  15. Dig Dis Sci. 2003 Mar;48(3):508-15 - PubMed
  16. Chaos. 2002 Sep;12(3):893-902 - PubMed
  17. Am J Dig Dis. 1963 Jan;8:54-102 - PubMed
  18. Am Heart J. 1964 Feb;67:200-20 - PubMed
  19. J Pediatr Gastroenterol Nutr. 2004 Jan;38(1):61-5 - PubMed
  20. J Physiol. 2004 Jul 1;558(Pt 1):75-83 - PubMed
  21. Circulation. 2005 May 31;111(21):2727-33 - PubMed
  22. Nature. 1970 Feb 7;225(5232):535-7 - PubMed
  23. Circulation. 2005 Aug 23;112(8):1232-40 - PubMed
  24. Nat Clin Pract Cardiovasc Med. 2005 Aug;2(8):408-14 - PubMed
  25. J Am Coll Cardiol. 2006 Mar 21;47(6):1196-206 - PubMed
  26. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G942-7 - PubMed
  27. J Physiol. 1913 Jul 18;46(4-5):349-83 - PubMed
  28. Am J Physiol. 1990 Oct;259(4 Pt 2):H1254-63 - PubMed
  29. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15727-8 - PubMed
  30. Eur Heart J. 1991 Dec;12 Suppl F:4-9 - PubMed
  31. Nature. 1992 Jan 23;355(6358):349-51 - PubMed
  32. J Physiol. 2007 Jul 15;582(Pt 2):755-65 - PubMed
  33. Gut. 2007 Jun;56(6):877-83 - PubMed
  34. Science. 1985 Nov 8;230(4726):661-3 - PubMed
  35. Gastroenterology. 2007 Sep;133(3):761-8 - PubMed
  36. Physiol Meas. 2008 May;29(5):N33-40 - PubMed
  37. Gastroenterology. 2008 Nov;135(5):1601-11 - PubMed
  38. J Pediatr Surg. 2008 Dec;43(12):e25-9 - PubMed
  39. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G211-8 - PubMed
  40. Exp Physiol. 2009 Apr;94(4):434-46 - PubMed
  41. Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1200-10 - PubMed
  42. Surgery. 2009 May;145(5):476-85 - PubMed
  43. Neurogastroenterol Motil. 2009 Dec;21(12):1269-e120 - PubMed
  44. Acta Physiol (Oxf). 2009 Dec;197(4):273-87 - PubMed
  45. Am J Physiol. 1990 Feb;258(2 Pt 1):G282-9 - PubMed
  46. Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H210-20 - PubMed
  47. Neurogastroenterol Motil. 2010 May;22(5):512-9, e114-5 - PubMed
  48. Phys Biol. 2010 Feb 10;7(1):16011 - PubMed
  49. Arch Inst Cardiol Mex. 1946 Jul;16(3):205-65 - PubMed
  50. Int J Cardiol. 2011 Jun 16;149(3):290-5 - PubMed
  51. Trends Pharmacol Sci. 2010 Jul;31(7):326-34 - PubMed
  52. Fundam Clin Pharmacol. 2010 Oct;24(5):547-59 - PubMed
  53. Neurogastroenterol Motil. 2010 Oct;22(10):1045-55 - PubMed
  54. Curr Gastroenterol Rep. 2010 Oct;12(5):408-16 - PubMed
  55. Heart Rhythm. 2010 Dec;7(12):1891-9 - PubMed
  56. Circ Arrhythm Electrophysiol. 2011 Feb;4(1):103-11 - PubMed
  57. Neurogastroenterol Motil. 2011 May;23(5):408-10 - PubMed
  58. J Physiol. 2011 May 1;589(Pt 9):2363-81 - PubMed
  59. J Physiol. 2011 May 1;589(Pt 9):2107-8 - PubMed
  60. Can J Gastroenterol. 2011 May;25(5):277-9 - PubMed
  61. Neurogastroenterol Motil. 2011 Sep;23(9):e345-55 - PubMed
  62. Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G684-9 - PubMed
  63. J Physiol Sci. 2012 Mar;62(2):79-92 - PubMed
  64. J Neurogastroenterol Motil. 2012 Jan;18(1):58-63 - PubMed
  65. Exp Physiol. 2012 Jul;97(7):807-21 - PubMed
  66. Gastroenterology. 2012 Sep;143(3):589-598.e3 - PubMed
  67. J Cardiovasc Pharmacol. 2012 Nov;60(5):456-66 - PubMed
  68. J Cardiovasc Pharmacol. 2013 Mar;61(3):204-14 - PubMed
  69. Neurogastroenterol Motil. 2013 Mar;25(3):e205-14 - PubMed
  70. Neurogastroenterol Motil. 2013 May;25(5):e304-14 - PubMed
  71. Neurogastroenterol Motil. 2013 May;25(5):353-7 - PubMed
  72. Drugs Today (Barc). 2013 Apr;49(4):239-52 - PubMed
  73. Front Neurosci. 2013 May 21;7:77 - PubMed
  74. J Gastroenterol Hepatol. 2013 Oct;28(10):1624-31 - PubMed
  75. Pacing Clin Electrophysiol. 1987 Mar;10(2):341-71 - PubMed
  76. Acta Physiol (Oxf). 2014 May;211(1):48-60 - PubMed
  77. Circ Res. 2014 Mar 14;114(6):1004-21 - PubMed
  78. Circ Res. 1989 May;64(5):977-90 - PubMed
  79. Clin Exp Pharmacol Physiol. 2014 Oct;41(10):854-62 - PubMed
  80. PLoS One. 2014 Aug 20;9(8):e105599 - PubMed
  81. Nat Genet. 2014 Nov;46(11):1245-9 - PubMed
  82. Case Rep Gastrointest Med. 2014;2014:923637 - PubMed
  83. Neurogastroenterol Motil. 2015 Mar;27(3):406-15 - PubMed
  84. Card Electrophysiol Clin. 2015 Jun;7(2):269-81 - PubMed
  85. Scand Cardiovasc J. 2016;50(1):28-35 - PubMed
  86. Int J Colorectal Dis. 2016 Feb;31(2):429-37 - PubMed
  87. Res Cardiovasc Med. 2015 Sep 07;4(4):e29614 - PubMed
  88. Eur Heart J. 1989 Sep;10 Suppl E:2-8 - PubMed
  89. Int J Cardiol Heart Vasc. 2015 Dec 07;9:75-82 - PubMed
  90. PLoS One. 2016 Feb 12;11(2):e0148858 - PubMed
  91. World J Gastroenterol. 2016 Feb 21;22(7):2242-55 - PubMed
  92. Biomed Rep. 2016 Mar;4(3):313-324 - PubMed
  93. Acta Physiol (Oxf). 2016 Dec;218(4):234-235 - PubMed
  94. J Arrhythm. 2016 Apr;32(2):75-81 - PubMed
  95. J Basic Clin Physiol Pharmacol. 2016 Sep 1;27(5):457-62 - PubMed
  96. Biomed Rep. 2016 Jun;4(6):673-680 - PubMed
  97. Front Physiol. 2016 May 31;7:182 - PubMed
  98. Front Physiol. 2016 May 31;7:188 - PubMed
  99. Ann Noninvasive Electrocardiol. 2017 Nov;22(6): - PubMed
  100. J Diabetes Res. 2016;2016:2848759 - PubMed
  101. Can J Physiol Pharmacol. 1989 Jul;67(7):757-64 - PubMed
  102. J Arrhythm. 2016 Oct;32(5):411-417 - PubMed
  103. J Geriatr Cardiol. 2016 Sep;13(9):811-812 - PubMed
  104. J Geriatr Cardiol. 2016 Sep;13(9):813-814 - PubMed
  105. Europace. 2017 Apr 1;19(4):696 - PubMed
  106. J Geriatr Cardiol. 2017 Sep;14(9):595-596 - PubMed
  107. BJR Case Rep. 2015 Jul 7;1(2):20150182 - PubMed
  108. Br J Pharmacol. 1988 Jul;94(3):789-96 - PubMed
  109. Circ Res. 1988 Feb;62(2):395-410 - PubMed
  110. Gastroenterology. 1987 Apr;92(4):993-9 - PubMed
  111. J Physiol. 1986 Feb;371:179-89 - PubMed
  112. Circ Res. 1986 Jan;58(1):96-108 - PubMed
  113. J Physiol. 1985 Sep;366:221-32 - PubMed
  114. Circ Res. 1977 Oct;41(4):415-23 - PubMed
  115. Nature. 1973 Dec 21-28;246(5434):508-9 - PubMed
  116. Am J Physiol. 1973 Jul;225(1):125-31 - PubMed
  117. Circ Res. 1973 Jul;33(1):54-62 - PubMed
  118. Arch Mal Coeur Vaiss. 1966 Feb;59(2):263-72 - PubMed
  119. Ann Intern Med. 1983 Mar;98(3):378-84 - PubMed
  120. Circulation. 1984 Jan;69(1):163-73 - PubMed
  121. Circulation. 1983 Jun;67(6):1356-67 - PubMed
  122. Gut. 1981 Sep;22(9):705-12 - PubMed
  123. Circ Res. 1981 Jul;49(1):255-65 - PubMed
  124. Circ Res. 1981 Nov;49(5):1129-39 - PubMed
  125. Circulation. 1980 Jan;61(1):182-91 - PubMed
  126. Am J Physiol. 1980 Jul;239(1):G59-68 - PubMed
  127. J Pediatr Surg. 1995 Mar;30(3):441-4 - PubMed
  128. Circulation. 1993 Sep;88(3):1177-89 - PubMed
  129. Ann Biomed Eng. 1994 Nov-Dec;22(6):592-609 - PubMed
  130. J Cardiovasc Electrophysiol. 1994 Nov;5(11):933-44 - PubMed
  131. J Cardiovasc Electrophysiol. 1993 Jun;4(3):338-55 - PubMed
  132. Circ Res. 1993 Mar;72(3):631-50 - PubMed
  133. Circ Res. 1977 Jul;41(1):9-18 - PubMed
  134. Circulation. 1996 Oct 15;94(8):1962-73 - PubMed
  135. Cardiovasc Res. 1996 Sep;32(3):593-603 - PubMed
  136. Circ Res. 1976 Aug;39(2):168-77 - PubMed
  137. J Physiol. 1999 Jan 15;514 ( Pt 2):515-31 - PubMed

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