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Kakkar A, Nambirajan A, Suri V, et al. Primary Bone Tumors of the Skull: Spectrum of 125 Cases, with Review of Literature. J Neurol Surg B Skull Base. 2016;77(4):319-25doi: 10.1055/s-0035-1570347.
Kakkar, A., Nambirajan, A., Suri, V., Sarkar, C., Kale, S. S., Singh, M., & Sharma, M. C. (2016). Primary Bone Tumors of the Skull: Spectrum of 125 Cases, with Review of Literature. Journal of neurological surgery. Part B, Skull base, 77(4), 319-25. https://doi.org/10.1055/s-0035-1570347
Kakkar, Aanchal, et al. "Primary Bone Tumors of the Skull: Spectrum of 125 Cases, with Review of Literature." Journal of neurological surgery. Part B, Skull base vol. 77,4 (2016): 319-25. doi: https://doi.org/10.1055/s-0035-1570347
Kakkar A, Nambirajan A, Suri V, Sarkar C, Kale SS, Singh M, Sharma MC. Primary Bone Tumors of the Skull: Spectrum of 125 Cases, with Review of Literature. J Neurol Surg B Skull Base. 2016 Aug;77(4):319-25. doi: 10.1055/s-0035-1570347. Epub 2016 Jan 04. PMID: 27441157; PMCID: PMC4949064.
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J Neurol Surg B Skull Base. 2016 Aug;77(4):319-25. doi: 10.1055/s-0035-1570347. Epub 2016 Jan 04.

Primary Bone Tumors of the Skull: Spectrum of 125 Cases, with Review of Literature.

Journal of neurological surgery. Part B, Skull base

Aanchal Kakkar, Aruna Nambirajan, Vaishali Suri, Chitra Sarkar, Shashank S Kale, Manmohan Singh, Mehar Chand Sharma

Affiliations

  1. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
  2. Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

PMID: 27441157 PMCID: PMC4949064 DOI: 10.1055/s-0035-1570347

Abstract

AIMS: Primary skull bone tumors, benign or malignant, are rare, and include a vast repertoire of lesions. These tumors are not reported systematically in the literature, with most studies being on individual entities or as single case reports.

METHODS: Primary bone tumors diagnosed over a period of 12 years were retrieved, histological diagnoses reviewed, and clinical parameters noted.

RESULTS: We identified 125 primary skull bone tumors. The mean age at diagnosis was 32 years (range: 2-65 years). Majority of patients were adults (82.4%); male preponderance was noted (72.8%). Malignant tumors were more frequent than benign tumors. Most common malignant tumor was chordoma (n = 37), while most common benign tumor was osteoma (n = 7). Tumors were most frequently located at the skull base, of which clivus was most common location. Chordomas accounted for majority of clival tumors, while chondrosarcoma predominated at other skull base locations. Benign tumors were extremely rare in skull base. Tumors of the vault bones were infrequent; with chondrosarcoma and osteoma being the most common malignant and benign tumors, respectively.

CONCLUSIONS: This is the largest series of primary skull bone tumors from India. Documentation of such a series will aid in approaching differential diagnosis of skull tumors in a systematic manner.

Keywords: bone tumors; chondrosarcoma; chordoma; skull; skull base

References

  1. Cancer. 2009 Aug 1;115(15):3483-8 - PubMed
  2. Neurol India. 2015 Sep-Oct;63(5):736-42 - PubMed
  3. Hum Pathol. 2006 Jul;37(7):845-53 - PubMed
  4. Cancer. 1983 Jun 15;51(12):2311-6 - PubMed
  5. Neurol Med Chir (Tokyo). 2008 Feb;48(2):72-6 - PubMed
  6. J Neurosurg. 1981 Dec;55(6):1001-3 - PubMed
  7. Lancet Oncol. 2015 Feb;16(2):e71-83 - PubMed
  8. Arch Pathol Lab Med. 2005 Jun;129(6):787-9 - PubMed
  9. J Neurosurg Pediatr. 2014 Apr;13(4):380-7 - PubMed
  10. Australas Radiol. 2006 Feb;50(1):63-5 - PubMed
  11. Acta Neurochir (Wien). 1978;45(1-2):163-75 - PubMed
  12. Surg Neurol. 1997 Aug;48(2):143-7 - PubMed
  13. Cancer. 1993 Apr 1;71(7):2210-6 - PubMed
  14. AJNR Am J Neuroradiol. 2010 Oct;31(9):1764-6 - PubMed
  15. Appl Immunohistochem Mol Morphol. 2009 Mar;17(2):131-8 - PubMed
  16. Mayo Clin Proc. 1983 Apr;58(4):268-72 - PubMed
  17. Neuro Oncol. 2014 Mar;16(3):372-81 - PubMed
  18. Laryngoscope. 1997 Jan;107(1):56-61 - PubMed
  19. J Clin Neurosci. 2009 Dec;16(12):1547-51 - PubMed
  20. J Clin Neurosci. 2011 Oct;18(10 ):1419-21 - PubMed
  21. Br J Neurosurg. 2011 Aug;25(4):446-53 - PubMed
  22. Brain Tumor Pathol. 2012 Oct;29(4):201-6 - PubMed
  23. Indian J Plast Surg. 2013 Sep;46(3):479-85 - PubMed
  24. Turk Neurosurg. 2008 Jul;18(3):249-53 - PubMed
  25. Neuropediatrics. 2012 Jun;43(3):140-5 - PubMed
  26. Neuropathology. 2006 Apr;26(2):141-6 - PubMed
  27. J Clin Oncol. 2012 Mar 20;30(9):914-20 - PubMed
  28. J Oral Maxillofac Surg. 2012 May;70(5):1093-5 - PubMed
  29. J Neurooncol. 1998 Oct;40(1):87-96 - PubMed
  30. Otolaryngol Clin North Am. 2015 Jun;48(3):501-14 - PubMed

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