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Langille G, Yang H, Zeisler SK, et al. Low energy cyclotron production and cyclometalation chemistry of iridium-192. Appl Radiat Isot. 2016;115:81-86doi: 10.1016/j.apradiso.2016.06.005.
Langille, G., Yang, H., Zeisler, S. K., Hoehr, C., Storr, T., Andreoiu, C., & Schaffer, P. (2016). Low energy cyclotron production and cyclometalation chemistry of iridium-192. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 11581-86. https://doi.org/10.1016/j.apradiso.2016.06.005
Langille, G, et al. "Low energy cyclotron production and cyclometalation chemistry of iridium-192." Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine vol. 115 (2016): 81-86. doi: https://doi.org/10.1016/j.apradiso.2016.06.005
Langille G, Yang H, Zeisler SK, Hoehr C, Storr T, Andreoiu C, Schaffer P. Low energy cyclotron production and cyclometalation chemistry of iridium-192. Appl Radiat Isot. 2016 Sep;115:81-86. doi: 10.1016/j.apradiso.2016.06.005. Epub 2016 Jun 07. PMID: 27344003.
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Appl Radiat Isot. 2016 Sep;115:81-86. doi: 10.1016/j.apradiso.2016.06.005. Epub 2016 Jun 07.

Low energy cyclotron production and cyclometalation chemistry of iridium-192.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

G Langille, H Yang, S K Zeisler, C Hoehr, T Storr, C Andreoiu, P Schaffer

Affiliations

  1. Department of Chemistry, Simon Fraser University, Burnaby, Canada.
  2. Life Sciences Division, TRIUMF, Vancouver, Canada.
  3. Department of Chemistry, Simon Fraser University, Burnaby, Canada; Life Sciences Division, TRIUMF, Vancouver, Canada.

PMID: 27344003 DOI: 10.1016/j.apradiso.2016.06.005

Abstract

This work demonstrates the labelling of a novel class of iridium lumophore with radioiridium, as proof-of-feasibility for producing and using the medically useful isotope iridium-192. Natural osmium was electroplated onto silver target backings in basic media and irradiated for up to two hours with ≤20μA of 12.8MeV protons. A range of iridium isotopes were generated, characterized and quantified using γ-spectroscopy methods. The target material was removed from the backings via oxidative dissolution with hydrogen peroxide, and the iridium radioisotopes isolated using an anion exchange resin. Both no-carrier-added as well as carrier-added formulations were then used in subsequent cyclometalation reactions.

Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords: Cyclometalation; Cyclotron; Iridium; Irradiation; Osmium

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