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Pinto IS, Mourão AA, da Silva EF, et al. Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats. Front Physiol. 2016;7:205doi: 10.3389/fphys.2016.00205.
Pinto, I. S., Mourão, A. A., da Silva, E. F., Camargo, A. S., Marques, S. M., Gomes, K. P., Fajemiroye, J. O., da Silva Reis, A. A., Rebelo, A. C., Ferreira-Neto, M. L., Rosa, D. A., Freiria-Oliveira, A. H., Castro, C. H., Colombari, E., Colugnati, D. B., & Pedrino, G. R. (2016). Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats. Frontiers in physiology, 7205. https://doi.org/10.3389/fphys.2016.00205
Pinto, Izabella S, et al. "Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats." Frontiers in physiology vol. 7 (2016): 205. doi: https://doi.org/10.3389/fphys.2016.00205
Pinto IS, Mourão AA, da Silva EF, Camargo AS, Marques SM, Gomes KP, Fajemiroye JO, da Silva Reis AA, Rebelo AC, Ferreira-Neto ML, Rosa DA, Freiria-Oliveira AH, Castro CH, Colombari E, Colugnati DB, Pedrino GR. Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats. Front Physiol. 2016 Jun 02;7:205. doi: 10.3389/fphys.2016.00205. eCollection 2016. PMID: 27313544; PMCID: PMC4889888.
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Front Physiol. 2016 Jun 02;7:205. doi: 10.3389/fphys.2016.00205. eCollection 2016.

Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats.

Frontiers in physiology

Izabella S Pinto, Aline A Mourão, Elaine F da Silva, Amanda S Camargo, Stefanne M Marques, Karina P Gomes, James O Fajemiroye, Angela A da Silva Reis, Ana C S Rebelo, Marcos L Ferreira-Neto, Daniel A Rosa, André H Freiria-Oliveira, Carlos H Castro, Eduardo Colombari, Diego B Colugnati, Gustavo R Pedrino

Affiliations

  1. Department of Physiological Sciences, Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil.
  2. Postgraduate Programme in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Goiás Goiânia, Brazil.
  3. Department of Biochemistry and Molecular Biology, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil.
  4. Department of Morphology, Biological Sciences Institute, Federal University of Goiás Goiânia, Brazil.
  5. Department of Physiology, College of Physical Education, Federal University of Uberlândia Uberlândia, Brazil.
  6. Department of Physiology and Pathology, School of Dentistry, São Paulo State University Araraquara, Brazil.

PMID: 27313544 PMCID: PMC4889888 DOI: 10.3389/fphys.2016.00205

Abstract

Intrathecal injection of bombesin (BBS) promoted hypertensive and sympathoexcitatory effects in normotensive (NT) rats. However, the involvement of rostral ventrolateral medulla (RVLM) in these responses is still unclear. In the present study, we investigated: (1) the effects of BBS injected bilaterally into RVLM on cardiorespiratory and sympathetic activity in NT and spontaneously hypertensive rats (SHR); (2) the contribution of RVLM BBS type 1 receptors (BB1) to the maintenance of hypertension in SHR. Urethane-anesthetized rats (1.2 g · kg(-1), i.v.) were instrumented to record mean arterial pressure (MAP), diaphragm (DIA) motor, and renal sympathetic nerve activity (RSNA). In NT rats and SHR, BBS (0.3 mM) nanoinjected into RVLM increased MAP (33.9 ± 6.6 and 37.1 ± 4.5 mmHg, respectively; p < 0.05) and RSNA (97.8 ± 12.9 and 84.5 ± 18.1%, respectively; p < 0.05). In SHR, BBS also increased DIA burst amplitude (115.3 ± 22.7%; p < 0.05). BB1 receptors antagonist (BIM-23127; 3 mM) reduced MAP (-19.9 ± 4.4 mmHg; p < 0.05) and RSNA (-17.7 ± 3.8%; p < 0.05) in SHR, but not in NT rats (-2.5 ± 2.8 mmHg; -2.7 ± 5.6%, respectively). These results show that BBS can evoke sympathoexcitatory and pressor responses by activating RVLM BB1 receptors. This pathway might be involved in the maintenance of high levels of arterial blood pressure in SHR.

Keywords: BB1 receptors; BIM-23127; SHR; bombesin; rostral ventrolateral medulla

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