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Lemaitre RN, Bartz TM, King IB, et al. Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest. J Nutr Sci. 2016;5:e12doi: 10.1017/jns.2016.2.
Lemaitre, R. N., Bartz, T. M., King, I. B., Brody, J. A., McKnight, B., Sotoodehnia, N., Rea, T. D., Johnson, C. O., Mozaffarian, D., Hesselson, S., Kwok, P. Y., & Siscovick, D. S. (2016). Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest. Journal of nutritional science, 5e12. https://doi.org/10.1017/jns.2016.2
Lemaitre, Rozenn N, et al. "Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest." Journal of nutritional science vol. 5 (2016): e12. doi: https://doi.org/10.1017/jns.2016.2
Lemaitre RN, Bartz TM, King IB, Brody JA, McKnight B, Sotoodehnia N, Rea TD, Johnson CO, Mozaffarian D, Hesselson S, Kwok PY, Siscovick DS. Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest. J Nutr Sci. 2016 Mar 01;5:e12. doi: 10.1017/jns.2016.2. eCollection 2016. PMID: 27313848; PMCID: PMC4791519.
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J Nutr Sci. 2016 Mar 01;5:e12. doi: 10.1017/jns.2016.2. eCollection 2016.

Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest.

Journal of nutritional science

Rozenn N Lemaitre, Traci M Bartz, Irena B King, Jennifer A Brody, Barbara McKnight, Nona Sotoodehnia, Thomas D Rea, Catherine O Johnson, Dariush Mozaffarian, Stephanie Hesselson, Pui-Yan Kwok, David S Siscovick

Affiliations

  1. Cardiovascular Health Research Unit , Department of Medicine , University of Washington , Seattle, WA , USA.
  2. Cardiovascular Health Research Unit , Department of Biostatistics , University of Washington , Seattle, WA , USA.
  3. Department of Internal Medicine , University of New Mexico , Albuquerque, NM , USA.
  4. Friedman School of Nutrition Science and Policy , Tufts University , Boston, MA , USA.
  5. Cardiovascular Research Institute and Institute for Human Genetics , University of California , San Francisco, CA , USA.
  6. New York Academy of Medicine , New York, NY , USA.

PMID: 27313848 PMCID: PMC4791519 DOI: 10.1017/jns.2016.2

Abstract

Whether genetic factors influence the associations of fatty acids with the risk of sudden cardiac arrest (SCA) is largely unknown. To investigate possible gene-fatty acid interactions on SCA risk, we used a case-only approach and measured fatty acids in erythrocyte samples from 1869 SCA cases in a population-based repository with genetic data. We selected 191 SNP in ENCODE-identified regulatory regions of fifty-five candidate genes in fatty acid metabolic pathways. Using linear regression and additive genetic models, we investigated the association of the selected SNP with erythrocyte levels of fatty acids, including DHA, EPA and trans-fatty acids among the SCA cases. The assumption of no association in non-cases was supported by analysis of publicly available datasets containing over 8000 samples. None of the SNP-fatty acid associations tested among the cases reached statistical significance after correction for multiple comparisons. One SNP, rs4654990 near PLA2G2A, with an allele frequency of 0·33, was nominally associated with lower levels of DHA and EPA and higher levels of trans-fatty acids. The strongest association was with DHA levels (exponentiated coefficient for one unit (1 % of total fatty acids), 0·90, 95 % CI 0·85, 0·97; P = 0·003), indicating that for subjects with a coded allele, the OR of SCA associated with one unit higher DHA is about 90 % what it is for subjects with one fewer coded allele. These findings suggest that the associations of circulating n-3 and trans-fatty acids with SCA risk may be more pronounced in carriers of the rs4654990 G allele.

Keywords: Epidemiology; Fatty acids; Genetics; SCA, sudden cardiac arrest; Sudden cardiac arrest; sPLA2, secretory phospholipase A2

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