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Costantini DL, Vali R, McQuattie S, et al. A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma. Int J Mol Imaging. 2016;2016:6045894doi: 10.1155/2016/6045894.
Costantini, D. L., Vali, R., McQuattie, S., Chan, J., Punnett, A., Weitzman, S., Shammas, A., & Charron, M. (2016). A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma. International journal of molecular imaging, 20166045894. https://doi.org/10.1155/2016/6045894
Costantini, Danny L, et al. "A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma." International journal of molecular imaging vol. 2016 (2016): 6045894. doi: https://doi.org/10.1155/2016/6045894
Costantini DL, Vali R, McQuattie S, Chan J, Punnett A, Weitzman S, Shammas A, Charron M. A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma. Int J Mol Imaging. 2016;2016:6045894. doi: 10.1155/2016/6045894. Epub 2016 May 26. PMID: 27313888; PMCID: PMC4899586.
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Int J Mol Imaging. 2016;2016:6045894. doi: 10.1155/2016/6045894. Epub 2016 May 26.

A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma.

International journal of molecular imaging

Danny L Costantini, Reza Vali, Susan McQuattie, Jeffrey Chan, Angela Punnett, Shiela Weitzman, Amer Shammas, Martin Charron

Affiliations

  1. Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Floor, Toronto, ON, Canada M5T 1W7; Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
  2. Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
  3. Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.

PMID: 27313888 PMCID: PMC4899586 DOI: 10.1155/2016/6045894

Abstract

We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned.

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