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Drexler ES, Slifka AJ, Wright JE, et al. An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex. J Res Natl Inst Stand Technol. 2003;108(3):183-91doi: 10.6028/jres.108.018.
Drexler, E. S., Slifka, A. J., Wright, J. E., McCowan, C. N., Finch, D. S., Quinn, T. P., McColskey, J. D., Ivy, D. D., & Shandas, R. (2003). An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex. Journal of research of the National Institute of Standards and Technology, 108(3), 183-91. https://doi.org/10.6028/jres.108.018
Drexler, E S, et al. "An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex." Journal of research of the National Institute of Standards and Technology vol. 108,3 (2003): 183-91. doi: https://doi.org/10.6028/jres.108.018
Drexler ES, Slifka AJ, Wright JE, McCowan CN, Finch DS, Quinn TP, McColskey JD, Ivy DD, Shandas R. An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex. J Res Natl Inst Stand Technol. 2003 Jun 01;108(3):183-91. doi: 10.6028/jres.108.018. Print 2003. PMID: 27413604; PMCID: PMC4844506.
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J Res Natl Inst Stand Technol. 2003 Jun 01;108(3):183-91. doi: 10.6028/jres.108.018. Print 2003.

An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex.

Journal of research of the National Institute of Standards and Technology

E S Drexler, A J Slifka, J E Wright, C N McCowan, D S Finch, T P Quinn, J D McColskey, D D Ivy, R Shandas

Affiliations

  1. National Institute of Standards and Technology, Boulder, CO 80305.
  2. Department of Pediatrics, Division of Cardiology, University of Colorado, Health Sciences Center, Denver, CO 80218.
  3. Department of Pediatrics, Division of Cardiology, University of Colorado, Health Sciences Center, Denver, CO 80218Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309.

PMID: 27413604 PMCID: PMC4844506 DOI: 10.6028/jres.108.018

Abstract

This paper describes a test method for measuring the mechanical properties of small, nonlinear membrane samples from a rat model for pulmonary hypertension. The size and nonlinearity of the pulmonary artery samples poses a challenge for developing a test method that will generate quality, reproducible data in the pressure range experienced by the hypertensive pulmonary artery. The experimental method described here has sufficient precision to yield a combined relative standard uncertainty of 4 %. The method is calibrated against 75 µm thick latex and the data agree well with the neo-Hookian model.

Keywords: apparatus; biaxial test; latex; mechanical properties; nonlinear material; pulmonary hypertension; rat pulmonary artery

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