Display options
Cite
Shimoda M, Jackson HW, Khokha R. Tumor suppression by stromal TIMPs. Mol Cell Oncol. 2016;3(3):e975082doi: 10.4161/23723556.2014.975082.
Shimoda, M., Jackson, H. W., & Khokha, R. (2016). Tumor suppression by stromal TIMPs. Molecular & cellular oncology, 3(3), e975082. https://doi.org/10.4161/23723556.2014.975082
Shimoda, Masayuki, et al. "Tumor suppression by stromal TIMPs." Molecular & cellular oncology vol. 3,3 (2016): e975082. doi: https://doi.org/10.4161/23723556.2014.975082
Shimoda M, Jackson HW, Khokha R. Tumor suppression by stromal TIMPs. Mol Cell Oncol. 2016 Mar 30;3(3):e975082. doi: 10.4161/23723556.2014.975082. eCollection 2016 May. PMID: 27314104; PMCID: PMC4909426.
Copy Download .nbib Format: NLM
Share it on

Mol Cell Oncol. 2016 Mar 30;3(3):e975082. doi: 10.4161/23723556.2014.975082. eCollection 2016 May.

Tumor suppression by stromal TIMPs.

Molecular & cellular oncology

Masayuki Shimoda, Hartland W Jackson, Rama Khokha

Affiliations

  1. Ontario Cancer Institute; University Health Network ; Toronto, Canada.

PMID: 27314104 PMCID: PMC4909426 DOI: 10.4161/23723556.2014.975082

Abstract

The tumor stroma has the capacity to drive cancer progression, although the mechanisms governing these effects are incompletely understood. Recently, we reported that deletion of tissue inhibitor of metalloproteinases (Timps) in fibroblasts unleashes the function of cancer-associated fibroblasts and identifies a novel mode of stromal-tumor communication that activates key oncogenic pathways invoving Notch and ras homolog gene family, member A (RhoA) via stromal exosomes.

Keywords: ADAM10; CAF; Notch; RhoA; TIMP; complete Timp deficiency; exosomes

References

  1. Cell. 2012 Dec 21;151(7):1542-56 - PubMed
  2. Nat Rev Immunol. 2013 Sep;13(9):649-65 - PubMed
  3. Nature. 2011 Dec 07;481(7379):85-9 - PubMed
  4. Nat Rev Cancer. 2006 May;6(5):392-401 - PubMed
  5. Proteomics. 2013 May;13(10-11):1624-36 - PubMed
  6. Semin Cell Dev Biol. 2010 Feb;21(1):19-25 - PubMed
  7. Cancer Cell. 2002 Oct;2(4):289-300 - PubMed
  8. Biochem J. 2006 Feb 1;393(Pt 3):609-18 - PubMed
  9. Proteomics. 2013 May;13(10-11):1608-23 - PubMed
  10. Nat Cell Biol. 2014 Sep;16(9):889-901 - PubMed

Publication Types