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Jovanovic P, Petkovic M, Simic M, et al. A novel thiourea type organocatalyst possessing a single NH functionality. Org Biomol Chem. 2016;14(28):6712-9doi: 10.1039/c6ob00387g.
Jovanovic, P., Petkovic, M., Simic, M., Ivkovic, B., & Savic, V. (2016). A novel thiourea type organocatalyst possessing a single NH functionality. Organic & biomolecular chemistry, 14(28), 6712-9. https://doi.org/10.1039/c6ob00387g
Jovanovic, Predrag, et al. "A novel thiourea type organocatalyst possessing a single NH functionality." Organic & biomolecular chemistry vol. 14,28 (2016): 6712-9. doi: https://doi.org/10.1039/c6ob00387g
Jovanovic P, Petkovic M, Simic M, Ivkovic B, Savic V. A novel thiourea type organocatalyst possessing a single NH functionality. Org Biomol Chem. 2016 Jul 12;14(28):6712-9. doi: 10.1039/c6ob00387g. PMID: 27314255.
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Org Biomol Chem. 2016 Jul 12;14(28):6712-9. doi: 10.1039/c6ob00387g.

A novel thiourea type organocatalyst possessing a single NH functionality.

Organic & biomolecular chemistry

Predrag Jovanovic, Milos Petkovic, Milena Simic, Branka Ivkovic, Vladimir Savic

Affiliations

  1. University of Belgrade, Faculty of Pharmacy, Department of Organic Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia. [email protected].
  2. University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia.

PMID: 27314255 DOI: 10.1039/c6ob00387g

Abstract

A novel thiourea organocatalyst was rationally designed by altering a typical H-bonding pattern of thiourea derivatives and utilising the potential of the 3,5-bis(trifluoromethyl)phenyl motif to participate in the H-bond formation. This unique catalyst afforded the products of the α-amination and Michael reaction in excellent yields and with a high level of stereoselectivity. Although additional studies are necessary to establish the full potential of the catalyst and to broaden its application further, the presented results may indicate alternative routes for further exploration of the thiourea class of organocatalysts.

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