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Rahimi A, Ahmadpanah M, Shamsaei F, et al. Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention. Neuropsychiatr Dis Treat. 2016;12:1507-15doi: 10.2147/NDT.S110978.
Rahimi, A., Ahmadpanah, M., Shamsaei, F., Cheraghi, F., Sadeghi Bahmani, D., Holsboer-Trachsler, E., & Brand, S. (2016). Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention. Neuropsychiatric disease and treatment, 121507-15. https://doi.org/10.2147/NDT.S110978
Rahimi, Alireza, et al. "Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention." Neuropsychiatric disease and treatment vol. 12 (2016): 1507-15. doi: https://doi.org/10.2147/NDT.S110978
Rahimi A, Ahmadpanah M, Shamsaei F, Cheraghi F, Sadeghi Bahmani D, Holsboer-Trachsler E, Brand S. Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention. Neuropsychiatr Dis Treat. 2016 Jun 22;12:1507-15. doi: 10.2147/NDT.S110978. eCollection 2016. PMID: 27382293; PMCID: PMC4922769.
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Neuropsychiatr Dis Treat. 2016 Jun 22;12:1507-15. doi: 10.2147/NDT.S110978. eCollection 2016.

Effect of adjuvant sleep hygiene psychoeducation and lorazepam on depression and sleep quality in patients with major depressive disorders: results from a randomized three-arm intervention.

Neuropsychiatric disease and treatment

Alireza Rahimi, Mohammad Ahmadpanah, Farshid Shamsaei, Fatemeh Cheraghi, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand

Affiliations

  1. Behavioral Disorders and Substances Abuses Research Center, Hamadan University of Medial Sciences, Hamadan.
  2. Research Center for Chronic Disease Care at Home, Hamadan University of Medial Sciences, Hamadan, Iran.
  3. Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders (ZASS).
  4. Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders (ZASS); Department of Sport, Exercise, and Health, Division of Sport and Psychosocial Health, University of Basel, Basel, Switzerland.

PMID: 27382293 PMCID: PMC4922769 DOI: 10.2147/NDT.S110978

Abstract

BACKGROUND: Sleep disturbances are a common co-occurring disturbance in patients with major depressive disorders (MDDs) and accordingly deserve particular attention. Using a randomized design, we investigated the effects of three different adjuvant interventions on sleep and depression among patients with MDD: a sleep hygiene program (SHP), lorazepam (LOR), and their combination (SHP-LOR).

METHODS: A total of 120 outpatients with diagnosed MDD (mean age: 48.25 years; 56.7% females) and treated with a standard SSRI (citalopram at 20-40 mg at therapeutic level) were randomly assigned to one of the following three conditions: SHP (n=40), LOR (1 mg/d; n=40), SHP-LOR (1 mg/d; n=40). At the beginning and at the end of the study 8 weeks later, patients completed two questionnaires, the Pittsburgh Sleep Quality Index to assess sleep and the Beck Depression Inventory to assess symptoms of depression.

RESULTS: Sleep disturbances decreased over time and in all groups. No group differences or interactions were observed. Symptoms of depression decreased over time and in all three groups. Reduction in symptoms of depression was greatest in the SHP-LOR group and lowest in the LOR group.

CONCLUSION: The pattern of results suggests that all three adjuvant treatments improved symptoms of sleep disturbances and depression, with greater benefits for the SHP-LOR for symptoms of depression, but not for sleep. Nevertheless, risks and benefits of benzodiazepine prescriptions should be taken into account.

Keywords: depression; lorazepam; pharmacotherapy; psychoeducation; sleep disturbances; sleep hygiene

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