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de Menezes KJ, Peixoto C, Nardi AE, et al. Dehydroepiandrosterone, Its Sulfate and Cognitive Functions. Clin Pract Epidemiol Ment Health. 2016;12:24-37doi: 10.2174/1745017901612010024.
de Menezes, K. J., Peixoto, C., Nardi, A. E., Carta, M. G., Machado, S., & Veras, A. B. (2016). Dehydroepiandrosterone, Its Sulfate and Cognitive Functions. Clinical practice and epidemiology in mental health : CP & EMH, 1224-37. https://doi.org/10.2174/1745017901612010024
de Menezes, Karina Junqueira, et al. "Dehydroepiandrosterone, Its Sulfate and Cognitive Functions." Clinical practice and epidemiology in mental health : CP & EMH vol. 12 (2016): 24-37. doi: https://doi.org/10.2174/1745017901612010024
de Menezes KJ, Peixoto C, Nardi AE, Carta MG, Machado S, Veras AB. Dehydroepiandrosterone, Its Sulfate and Cognitive Functions. Clin Pract Epidemiol Ment Health. 2016 Apr 29;12:24-37. doi: 10.2174/1745017901612010024. eCollection 2016. PMID: 27346998; PMCID: PMC4894834.
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Clin Pract Epidemiol Ment Health. 2016 Apr 29;12:24-37. doi: 10.2174/1745017901612010024. eCollection 2016.

Dehydroepiandrosterone, Its Sulfate and Cognitive Functions.

Clinical practice and epidemiology in mental health : CP & EMH

Karina Junqueira de Menezes, Clayton Peixoto, Antonio Egidio Nardi, Mauro Giovanni Carta, Sérgio Machado, André Barciela Veras

Affiliations

  1. Laboratory of Panic and Respiration, Institute of Psychiatry, UFRJ (Federal University of Rio de Janeiro), Brazil.
  2. Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy.
  3. Dom Bosco Catholic University (UCDB), Laboratory of Panic and Respiration, Institute of Psychiatry, UFRJ, Brazil.

PMID: 27346998 PMCID: PMC4894834 DOI: 10.2174/1745017901612010024

Abstract

UNLABELLED: To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition.

METHODS: The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A systematic review was proceeded using three databases: PubMed, ISI Web of Science, and PsycINFO.

RESULTS: Two thousand fifty five references about cognition and hormones were found; 772 duplicated references were excluded, resulting in 1.283 references to be evaluated. According to exclusion and inclusion criteria, 25 references were selected. A positive correlation between DHEA-S blood levels and global cognition was found in women and men. Other positive correlations between DHEA-S and working memory, attention and verbal fluency were found only in women. The DHEA effect on cognition is limited to one study conducted among young men with high-doses.

Keywords: Attention; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Executive Function; Memory; Neuropsychology

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