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Sheng X, Zhong H, Wan H, et al. Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line. Exp Ther Med. 2016;12(1):396-404doi: 10.3892/etm.2016.3268.
Sheng, X., Zhong, H., Wan, H., Zhong, J., & Chen, F. (2016). Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line. Experimental and therapeutic medicine, 12(1), 396-404. https://doi.org/10.3892/etm.2016.3268
Sheng, Xianfu, et al. "Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line." Experimental and therapeutic medicine vol. 12,1 (2016): 396-404. doi: https://doi.org/10.3892/etm.2016.3268
Sheng X, Zhong H, Wan H, Zhong J, Chen F. Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line. Exp Ther Med. 2016 Jul;12(1):396-404. doi: 10.3892/etm.2016.3268. Epub 2016 Apr 20. PMID: 27347068; PMCID: PMC4906714.
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Exp Ther Med. 2016 Jul;12(1):396-404. doi: 10.3892/etm.2016.3268. Epub 2016 Apr 20.

Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line.

Experimental and therapeutic medicine

Xianfu Sheng, Hua Zhong, Haixia Wan, Jihua Zhong, Fangyuan Chen

Affiliations

  1. Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China.

PMID: 27347068 PMCID: PMC4906714 DOI: 10.3892/etm.2016.3268

Abstract

Combining cytarabine, aclarubicin and granulocyte colony-stimulating factor (G-CSF) has demonstrated marked efficacy in the treatment of elderly and relapsed/refractory patients with acute myeloid leukemia (AML); however, the role of G-CSF remains poorly understood. The present study aimed to investigate the ability of G-CSF to overcome stromal-mediated drug resistance and the underlying molecular mechanism. Two types of co-culture models were established in the HS-5 human bone marrow/stromal and HL-60 human promyelocytic leukemia cell lines, in order to imitate the interactions between stromal and leukemia cells

Keywords: AMD3100; C-X-C chemokine receptor type 4/stromal cell-derived factor-1α axis; drug resistance; granulocyte colony-stimulating factor; microRNA-146a

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