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Nicol GE, Kolko RP, Mills M, et al. Behavioral Weight Loss Treatment in Antipsychotic Treated Youth. Scand J Child Adolesc Psychiatr Psychol. 2016;4(2):96-104doi: 10.21307/sjcapp-2016-014.
Nicol, G. E., Kolko, R. P., Mills, M., Gunnarsdottir, T., Yingling, M. D., Schweiger, J. A., Lenze, E. J., Newcomer, J. W., & Wilfley, D. (2016). Behavioral Weight Loss Treatment in Antipsychotic Treated Youth. Scandinavian journal of child and adolescent psychiatry and psychology, 4(2), 96-104. https://doi.org/10.21307/sjcapp-2016-014
Nicol, Ginger E, et al. "Behavioral Weight Loss Treatment in Antipsychotic Treated Youth." Scandinavian journal of child and adolescent psychiatry and psychology vol. 4,2 (2016): 96-104. doi: https://doi.org/10.21307/sjcapp-2016-014
Nicol GE, Kolko RP, Mills M, Gunnarsdottir T, Yingling MD, Schweiger JA, Lenze EJ, Newcomer JW, Wilfley D. Behavioral Weight Loss Treatment in Antipsychotic Treated Youth. Scand J Child Adolesc Psychiatr Psychol. 2016 May;4(2):96-104. doi: 10.21307/sjcapp-2016-014. PMID: 27347489; PMCID: PMC4916921.
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Scand J Child Adolesc Psychiatr Psychol. 2016 May;4(2):96-104. doi: 10.21307/sjcapp-2016-014.

Behavioral Weight Loss Treatment in Antipsychotic Treated Youth.

Scandinavian journal of child and adolescent psychiatry and psychology

Ginger E Nicol, Rachel P Kolko, Monica Mills, Thrudur Gunnarsdottir, Michael D Yingling, Julia A Schweiger, Eric J Lenze, John W Newcomer, Denise Wilfley

Affiliations

  1. Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis MO.
  2. Department of Psychiatry, Western Psychiatric Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
  3. Department of Psychology, University of Akureyri, Iceland.
  4. Weight Management & Eating Disorders Program, Department of Psychiatry, Washington University School of Medicine, St. Louis MO.
  5. Weight Management & Eating Disorders Program, Department of Psychiatry, Washington University School of Medicine, St. Louis MO; Department of Psychology, Washington University School of Medicine, St. Louis, MO; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO; Department of Pediatrics, Washington University School of Medicine, St. Louis MO.

PMID: 27347489 PMCID: PMC4916921 DOI: 10.21307/sjcapp-2016-014

Abstract

BACKGROUND: Antipsychotic-treated youth have increased risk for the development of obesity and type 2 diabetes. Behavioral weight loss treatments show promise in reducing obesity and diabetes risk in antipsychotic treated adults, but have received no study in antipsychotic treated youth.

OBJECTIVE: We describe a rationale for behavioral weight loss interventions in high-weight antipsychotic treated youth, and report behavioral, anthropomorphic, and metabolic findings from a case series of obese antipsychotic-treated adolescents participating in a short-term, family-based behavioral weight loss intervention.

METHODS: We adapted the Traffic Light Plan, a 16-week family-based weight loss intervention that promotes healthy energy balance using the colors of the traffic light to categorize the nutritional value of foods and intensity of physical activity, adapting a social ecological framework to address health behavior change in multiple social contexts. The intervention was administered to three obese adolescents with long-term antipsychotic medication exposure. Efficacy of the intervention was evaluated with a battery of anthropomorphic and metabolic assessments including weight, body mass index percentile, whole body adiposity, liver fat content, and fasting plasma glucose and lipids. Participants and their parents also filled out a treatment satisfaction questionnaire upon study completion.

RESULTS: Two males and 1 female (all aged 14 years) participated. All 3 participants attended all 16 sessions, and experienced beneficial changes in adiposity, fasting lipids and liver fat content associated with weight stabilization or weight loss. Adolescents and their parents all reported a high level of satisfaction with the treatment.

CONCLUSIONS: Family-based behavioral weight loss treatment can be feasibly delivered and is acceptable to antipsychotic-treated youth and their families. Randomized controlled trials are needed to fully evaluate the effectiveness and acceptability of behavioral weight loss interventions in antipsychotic treated youth and their families.

Keywords: Antipsychotic; At-Risk Youth; Pediatric Obesity; Weight Loss Treatment

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