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Yuan FL, Xu MH, Li X, et al. The Roles of Acidosis in Osteoclast Biology. Front Physiol. 2016;7:222doi: 10.3389/fphys.2016.00222.
Yuan, F. L., Xu, M. H., Li, X., Xinlong, H., Fang, W., & Dong, J. (2016). The Roles of Acidosis in Osteoclast Biology. Frontiers in physiology, 7222. https://doi.org/10.3389/fphys.2016.00222
Yuan, Feng-Lai, et al. "The Roles of Acidosis in Osteoclast Biology." Frontiers in physiology vol. 7 (2016): 222. doi: https://doi.org/10.3389/fphys.2016.00222
Yuan FL, Xu MH, Li X, Xinlong H, Fang W, Dong J. The Roles of Acidosis in Osteoclast Biology. Front Physiol. 2016 Jun 24;7:222. doi: 10.3389/fphys.2016.00222. eCollection 2016. PMID: 27445831; PMCID: PMC4919343.
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Front Physiol. 2016 Jun 24;7:222. doi: 10.3389/fphys.2016.00222. eCollection 2016.

The Roles of Acidosis in Osteoclast Biology.

Frontiers in physiology

Feng-Lai Yuan, Ming-Hui Xu, Xia Li, He Xinlong, Wei Fang, Jian Dong

Affiliations

  1. Department of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University Wuxi, China.
  2. Department of Neurosurgery, Wuxi Ninth People's Hospital Affiliated to Soochow University Liangxi Road Wuxi, China.
  3. Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University Shanghai, China.

PMID: 27445831 PMCID: PMC4919343 DOI: 10.3389/fphys.2016.00222

Abstract

The adverse effect of acidosis on the skeletal system has been recognized for almost a century. Although the underlying mechanism has not been fully elucidated, it appears that acidosis acts as a general stimulator of osteoclasts derived from bone marrow precursors cells and enhances osteoclastic resorption. Prior work suggests that acidosis plays a significant role in osteoclasts formation and activation via up-regulating various genes responsible for its adhesion, migration, survival and bone matrix degradation. Understanding the role of acidosis in osteoclast biology may lead to development of novel therapeutic approaches for the treatment of diseases related to low bone mass. In this review, we aim to discuss the recent investigations into the effects of acidosis in osteoclast biology and the acid-sensing molecular mechanism.

Keywords: acidosis; osteoclast; osteoclast activity; osteoclast adhesion; osteoclast survival

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