Display options
Cite
Xia J, Sun Y, Yuan J, et al. Hemodynamic effects of ephedrine and phenylephrine bolus injection in patients in the prone position under general anesthesia for lumbar spinal surgery. Exp Ther Med. 2016;12(2):1141-1146doi: 10.3892/etm.2016.3432.
Xia, J., Sun, Y., Yuan, J., Lu, X., Peng, Z., & Yin, N. (2016). Hemodynamic effects of ephedrine and phenylephrine bolus injection in patients in the prone position under general anesthesia for lumbar spinal surgery. Experimental and therapeutic medicine, 12(2), 1141-1146. https://doi.org/10.3892/etm.2016.3432
Xia, Jiangyan, et al. "Hemodynamic effects of ephedrine and phenylephrine bolus injection in patients in the prone position under general anesthesia for lumbar spinal surgery." Experimental and therapeutic medicine vol. 12,2 (2016): 1141-1146. doi: https://doi.org/10.3892/etm.2016.3432
Xia J, Sun Y, Yuan J, Lu X, Peng Z, Yin N. Hemodynamic effects of ephedrine and phenylephrine bolus injection in patients in the prone position under general anesthesia for lumbar spinal surgery. Exp Ther Med. 2016 Aug;12(2):1141-1146. doi: 10.3892/etm.2016.3432. Epub 2016 Jun 07. PMID: 27446334; PMCID: PMC4950852.
Copy Download .nbib Format: NLM
Share it on

Exp Ther Med. 2016 Aug;12(2):1141-1146. doi: 10.3892/etm.2016.3432. Epub 2016 Jun 07.

Hemodynamic effects of ephedrine and phenylephrine bolus injection in patients in the prone position under general anesthesia for lumbar spinal surgery.

Experimental and therapeutic medicine

Jiangyan Xia, Yongying Sun, Jing Yuan, Xinjian Lu, Zhendan Peng, Ning Yin

Affiliations

  1. Department of Anesthesiology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, P.R. China.
  2. Department of Stomatology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, P.R. China.

PMID: 27446334 PMCID: PMC4950852 DOI: 10.3892/etm.2016.3432

Abstract

Ephedrine and phenylephrine (PE) are vasoconstrictors commonly used to restore the blood pressure (BP) to normal values. The aim of the present study was to investigate the effects of ephedrine and PE bolus administration on intra-arterial systolic BP (ISBP), intra-arterial diastolic BP (IDBP) and cardiac output (CO) in patients undergoing lumbar spine surgery in the prone position under general anesthesia (GA). In this prospective, randomized, and double-blind study, a total of 60 patients aged 20-60 years and undergoing elective lumbar spine surgery were administered either a single dose of ephedrine (0.1 mg/kg) or PE (1 µg/kg) through a central venous catheter as a bolus injection following the achievement of a stable hemodynamic status for ≥10 min. Following bolus injection of ephedrine or PE, a significant increase in ISBP was observed in the two experimental groups compared with pre-ephedrine and pre-PE values. The duration of the increment in ISBP however was significantly longer in the ephedrine group compared with the PE group. A similar response was observed in IDBP. A significant increase in CO began 1 min following ephedrine injection and lasted for the entire observation period, whereas the increase was only sustained for 3 min following bolus injection in the PE group. The results of the present study demonstrated that bolus ephedrine produces a more persistent pressor response and durable increase in CO and CI compared with PE when patients are in the prone position with GA for spine surgery.

Keywords: ephedrine; general anesthesia; hemodynamic; phenylephrine; prone position

References

  1. Anesthesiology. 2005 Oct;103(4):744-50 - PubMed
  2. Anesthesiology. 2010 Aug;113(2):305-12 - PubMed
  3. Acta Anaesthesiol Taiwan. 2008 Jun;46(2):57-60 - PubMed
  4. Br J Anaesth. 2010 Apr;104(4):407-13 - PubMed
  5. Neurocrit Care. 2011 Aug;15(1):46-54 - PubMed
  6. Clin Med Insights Circ Respir Pulm Med. 2013 Sep 08;7:45-51 - PubMed
  7. Anesthesiology. 2009 Dec;111(6):1217-26 - PubMed
  8. Anesth Analg. 2002 May;94(5):1207-11, table of contents - PubMed
  9. Crit Care. 2010;14(2):124 - PubMed
  10. Anesth Analg. 2011 Aug;113(2):297-304 - PubMed
  11. Anesth Analg. 1999 Jul;89(1):37-41 - PubMed
  12. Indian J Anaesth. 2011 Mar;55(2):111-5 - PubMed
  13. Hypertens Res. 2005 Sep;28(9):741-6 - PubMed
  14. Anesth Analg. 1999 Oct;89(4):814-22 - PubMed
  15. Spine (Phila Pa 1976). 2005 Jun 1;30(11):1299-302 - PubMed
  16. Br J Anaesth. 2006 Jan;96(1):95-9 - PubMed
  17. Anesth Analg. 2011 Aug;113(2):284-96 - PubMed
  18. Br J Anaesth. 2011 Aug;107(2):209-17 - PubMed
  19. Anesth Analg. 2011 Oct;113(4):751-7 - PubMed
  20. J Appl Physiol (1985). 2012 Jul;113(2):281-9 - PubMed
  21. Anesthesiology. 2008 Apr;108(4):735-48 - PubMed
  22. Anesthesiology. 1991 Apr;74(4):705-10 - PubMed
  23. Lancet. 1991 May 25;337(8752):1244-7 - PubMed
  24. Anesth Analg. 2005 Sep;101(3):622-8, table of contents - PubMed
  25. J Clin Anesth. 1998 Feb;10(1):32-5 - PubMed
  26. Anesthesiology. 1968 Jul-Aug;29(4):732-62 - PubMed
  27. Anesthesiology. 2009 Oct;111(4):753-65 - PubMed
  28. Neurocrit Care. 2010 Feb;12(1):17-23 - PubMed
  29. Anesth Analg. 1998 Aug;87(2):347-54 - PubMed
  30. Anesth Analg. 1998 Dec;87(6):1336-9 - PubMed
  31. Anesthesiology. 2012 Mar;116(3):658-64 - PubMed
  32. Br J Anaesth. 2004 Dec;93(6):825-32 - PubMed
  33. Spine (Phila Pa 1976). 2006 May 20;31(12):1388-93; discussion 1394 - PubMed
  34. Anesthesiology. 2011 Mar;114(3):557-64 - PubMed

Publication Types