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Pannier D, Philippin-Lauridant G, Baranzelli MC, et al. High expression levels of egfl7 correlate with low endothelial cell activation in peritumoral vessels of human breast cancer. Oncol Lett. 2016;12(2):1422-1428doi: 10.3892/ol.2016.4791.
Pannier, D., Philippin-Lauridant, G., Baranzelli, M. C., Bertin, D., Bogart, E., Delprat, V., Villain, G., Mattot, V., Bonneterre, J., & Soncin, F. (2016). High expression levels of egfl7 correlate with low endothelial cell activation in peritumoral vessels of human breast cancer. Oncology letters, 12(2), 1422-1428. https://doi.org/10.3892/ol.2016.4791
Pannier, Diane, et al. "High expression levels of egfl7 correlate with low endothelial cell activation in peritumoral vessels of human breast cancer." Oncology letters vol. 12,2 (2016): 1422-1428. doi: https://doi.org/10.3892/ol.2016.4791
Pannier D, Philippin-Lauridant G, Baranzelli MC, Bertin D, Bogart E, Delprat V, Villain G, Mattot V, Bonneterre J, Soncin F. High expression levels of egfl7 correlate with low endothelial cell activation in peritumoral vessels of human breast cancer. Oncol Lett. 2016 Aug;12(2):1422-1428. doi: 10.3892/ol.2016.4791. Epub 2016 Jun 28. PMID: 27446447; PMCID: PMC4950557.
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Oncol Lett. 2016 Aug;12(2):1422-1428. doi: 10.3892/ol.2016.4791. Epub 2016 Jun 28.

High expression levels of egfl7 correlate with low endothelial cell activation in peritumoral vessels of human breast cancer.

Oncology letters

Diane Pannier, Géraldine Philippin-Lauridant, Marie-Christine Baranzelli, Delphine Bertin, Emilie Bogart, Victor Delprat, Gaëlle Villain, Virginie Mattot, Jacques Bonneterre, Fabrice Soncin

Affiliations

  1. Senology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France; Institut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.
  2. Senology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France.
  3. Institut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.

PMID: 27446447 PMCID: PMC4950557 DOI: 10.3892/ol.2016.4791

Abstract

Tumor blood vessels participate in the immune response against cancer cells and we previously used pre-clinical models to demonstrate that egfl7 (VE-statin) promotes tumor cell evasion from the immune system by repressing endothelial cell activation, preventing immune cells from entering the tumor mass. In the present study, the expression levels of egfl7 and that of ICAM-1 as a marker of endothelium activation, were evaluated in peritumoral vessels of human breast cancer samples. Breast cancer samples (174 invasive and 30

Keywords: blood vessels; breast cancer; endothelium activation; immunity

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