Display options
Cite
Nishiyama K, Esaki S, Deguchi I, et al. Syntheses of Isoflavones and Isoflavone Glycosides, and Their Inhibitory Activity against Bovine Liver β-Galactosidase. Biosci Biotechnol Biochem. 1993;57(1):107-14doi: 10.1271/bbb.57.107.
Nishiyama, K., Esaki, S., Deguchi, I., Sugiyama, N., & Kamiya, S. (1993). Syntheses of Isoflavones and Isoflavone Glycosides, and Their Inhibitory Activity against Bovine Liver β-Galactosidase. Bioscience, biotechnology, and biochemistry, 57(1), 107-14. https://doi.org/10.1271/bbb.57.107
Nishiyama, K, et al. "Syntheses of Isoflavones and Isoflavone Glycosides, and Their Inhibitory Activity against Bovine Liver β-Galactosidase." Bioscience, biotechnology, and biochemistry vol. 57,1 (1993): 107-14. doi: https://doi.org/10.1271/bbb.57.107
Nishiyama K, Esaki S, Deguchi I, Sugiyama N, Kamiya S. Syntheses of Isoflavones and Isoflavone Glycosides, and Their Inhibitory Activity against Bovine Liver β-Galactosidase. Biosci Biotechnol Biochem. 1993 Jan;57(1):107-14. doi: 10.1271/bbb.57.107. PMID: 27316881.
Copy Download .nbib Format: NLM
Share it on

Biosci Biotechnol Biochem. 1993 Jan;57(1):107-14. doi: 10.1271/bbb.57.107.

Syntheses of Isoflavones and Isoflavone Glycosides, and Their Inhibitory Activity against Bovine Liver β-Galactosidase.

Bioscience, biotechnology, and biochemistry

K Nishiyama, S Esaki, I Deguchi, N Sugiyama, S Kamiya

Affiliations

  1. a Laboratory of Organic and Food Chemistry, School of Food and Nutritional Sciences, University of Shizuoka , Shizuoka 422 , Japan.

PMID: 27316881 DOI: 10.1271/bbb.57.107

Abstract

To clarify the relationship between the structure and inhibitory action toward β-D-galactosidase (EC 3.2.1.21) of isoflavones and isoflavone glycosides, a number of polyhydroxyisoflavones, and the α-L-rhamnosides and β-L-quinovosides of daidzein and genistein were synthesized. Among the polyhydroxyisoflavones, 2',3',4',7-tetrahydroxyisoflavone showed the strongest inhibitory activity (Ki = 26 × 10(-6) M). Among the glycosides, all the L-rhamnosides were strong inhibitors, of which genistein 4',7-di-O-α-L-rhamnoside was the strongest (Ki = 4.44 × 10(-6) M), while all the isoflavone β-L-quinovosides were considerably weak or possessed no inhibition.

Publication Types