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Stephenson KE, Neubauer GH, Bricault CA, et al. Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy. Open Forum Infect Dis. 2016;3(2):ofw100doi: 10.1093/ofid/ofw100.
Stephenson, K. E., Neubauer, G. H., Bricault, C. A., Shields, J., Bayne, M., Reimer, U., Pawlowski, N., Knaute, T., Zerweck, J., Seaman, M. S., Rosenberg, E. S., & Barouch, D. H. (2016). Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy. Open forum infectious diseases, 3(2), ofw100. https://doi.org/10.1093/ofid/ofw100
Stephenson, Kathryn E, et al. "Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy." Open forum infectious diseases vol. 3,2 (2016): ofw100. doi: https://doi.org/10.1093/ofid/ofw100
Stephenson KE, Neubauer GH, Bricault CA, Shields J, Bayne M, Reimer U, Pawlowski N, Knaute T, Zerweck J, Seaman MS, Rosenberg ES, Barouch DH. Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy. Open Forum Infect Dis. 2016 May 19;3(2):ofw100. doi: 10.1093/ofid/ofw100. eCollection 2016 Apr. PMID: 27419172; PMCID: PMC4943535.
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Open Forum Infect Dis. 2016 May 19;3(2):ofw100. doi: 10.1093/ofid/ofw100. eCollection 2016 Apr.

Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy.

Open forum infectious diseases

Kathryn E Stephenson, George H Neubauer, Christine A Bricault, Jennifer Shields, Madeleine Bayne, Ulf Reimer, Nikolaus Pawlowski, Tobias Knaute, Johannes Zerweck, Michael S Seaman, Eric S Rosenberg, Dan H Barouch

Affiliations

  1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School; Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts.
  2. Center for Virology and Vaccine Research , Beth Israel Deaconess Medical Center, Harvard Medical School.
  3. JPT Peptide Technologies , Berlin , Germany.
  4. Massachusetts General Hospital , Boston.

PMID: 27419172 PMCID: PMC4943535 DOI: 10.1093/ofid/ofw100

Abstract

The examination of antibody responses in human immunodeficiency virus (HIV)-1-infected individuals in the setting of antiretroviral treatment (ART) interruption can provide insight into the evolution of antibody responses during viral rebound. In this study, we assessed antibody responses in 20 subjects in AIDS Clinical Trials Group A5187, wherein subjects were treated with antiretroviral therapy during acute/early HIV-1 infection, underwent analytic treatment interruption, and subsequently demonstrated viral rebound. Our data suggest that early initiation of ART arrests the maturation of HIV-1-specific antibody responses, preventing epitope diversification of antibody binding and the development of functional neutralizing capacity. Antibody responses do not appear permanently blunted, however, because viral rebound triggered the resumption of antibody maturation in our study. We also found that antibody responses measured by these assays did not predict imminent viral rebound. These data have important implications for the HIV-1 vaccine and eradication fields.

Keywords: HIV eradication; HIV vaccine; antibody; microarray; treatment interruption

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