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Bonsu KO, Owusu IK, Buabeng KO, et al. Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies. Ther Clin Risk Manag. 2016;12:887-906doi: 10.2147/TCRM.S106065.
Bonsu, K. O., Owusu, I. K., Buabeng, K. O., Reidpath, D. D., & Kadirvelu, A. (2016). Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies. Therapeutics and clinical risk management, 12887-906. https://doi.org/10.2147/TCRM.S106065
Bonsu, Kwadwo Osei, et al. "Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies." Therapeutics and clinical risk management vol. 12 (2016): 887-906. doi: https://doi.org/10.2147/TCRM.S106065
Bonsu KO, Owusu IK, Buabeng KO, Reidpath DD, Kadirvelu A. Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies. Ther Clin Risk Manag. 2016 Jun 03;12:887-906. doi: 10.2147/TCRM.S106065. eCollection 2016. PMID: 27350750; PMCID: PMC4902145.
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Ther Clin Risk Manag. 2016 Jun 03;12:887-906. doi: 10.2147/TCRM.S106065. eCollection 2016.

Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies.

Therapeutics and clinical risk management

Kwadwo Osei Bonsu, Isaac Kofi Owusu, Kwame Ohene Buabeng, Daniel Diamond Reidpath, Amudha Kadirvelu

Affiliations

  1. School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, Malaysia; Accident and Emergency Directorate, Komfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  2. Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  3. Department of Clinical and Social Pharmacy, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  4. School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, Malaysia.

PMID: 27350750 PMCID: PMC4902145 DOI: 10.2147/TCRM.S106065

Abstract

Heart failure (HF) is a major public health priority due to its epidemiological transition and the world's aging population. HF is typified by continuous loss of contractile function with reduced, normal, or preserved ejection fraction, elevated vascular resistance, fluid and autonomic imbalance, and ventricular dilatation. Despite considerable advances in the treatment of HF over the past few decades, mortality remains substantial. Pharmacological treatments including β-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone antagonists have been proven to prolong the survival of patients with HF. However, there are still instances where patients remain symptomatic, despite optimal use of existing therapeutic agents. This understanding that patients with chronic HF progress into advanced stages despite receiving optimal treatment has increased the quest for alternatives, exploring the roles of additional pathways that contribute to the development and progression of HF. Several pharmacological targets associated with pathogenesis of HF have been identified and novel therapies have emerged. In this work, we review recent evidence from proposed mechanisms to the outcomes of experimental and clinical studies of the novel pharmacological agents that have emerged for the treatment of HF.

Keywords: experimental and clinical studies; heart failure; novel treatment; therapeutic targets

References

  1. Lancet. 2015 Feb 28;385(9970):812-24 - PubMed
  2. Cell. 2000 May 12;101(4):365-76 - PubMed
  3. Pharmacol Res. 2004 Jan;49(1):1-5 - PubMed
  4. N Engl J Med. 2011 Jul 7;365(1):32-43 - PubMed
  5. Circ Heart Fail. 2015 Mar;8(2):252-60 - PubMed
  6. Am J Cardiol. 2005 May 2;95(9A):8B-13B - PubMed
  7. Eur Heart J. 2004 Feb;25(4):292-9 - PubMed
  8. Adv Pharmacol. 2010;59:1-30 - PubMed
  9. J Cell Mol Med. 2012 Dec;16(12):3052-61 - PubMed
  10. J Cardiovasc Pharmacol. 1995 Mar;25(3):469-72 - PubMed
  11. Eur J Heart Fail. 2011 Jan;13(1):107-14 - PubMed
  12. Int J Cardiol. 2013 Sep 20;168(1):212-8 - PubMed
  13. J Cardiovasc Pharmacol. 2004 Jul;44(1):101-8 - PubMed
  14. FEBS Lett. 1992 Nov 9;312(2-3):229-35 - PubMed
  15. Lancet. 2000 Aug 19;356(9230):615-20 - PubMed
  16. Acta Pharmacol Sin. 2005 Jun;26(6):696-704 - PubMed
  17. J Mol Cell Cardiol. 2001 Jun;33(6):1053-63 - PubMed
  18. J Clin Pharmacol. 2010 Apr;50(4):401-14 - PubMed
  19. Acta Pharm. 2014 Mar;64(1):105-15 - PubMed
  20. Circulation. 2005 Nov 22;112(21):3280-8 - PubMed
  21. N Engl J Med. 1982 Jul 22;307(4):205-11 - PubMed
  22. ChemMedChem. 2012 Aug;7(8):1385-403 - PubMed
  23. Circ Res. 2006 Feb 3;98(2):169-71 - PubMed
  24. J Pharmacol Exp Ther. 2007 Apr;321(1):213-20 - PubMed
  25. Hypertension. 2010 Apr;55(4):932-8 - PubMed
  26. J Card Fail. 2008 Mar;14(2):140-4 - PubMed
  27. Arch Intern Med. 2005 Jan 10;165(1):62-7 - PubMed
  28. Circ Res. 2014 Jan 3;114(1):101-8 - PubMed
  29. Expert Rev Cardiovasc Ther. 2004 Nov;2(6):803-13 - PubMed
  30. Lancet. 2012 Oct 20;380(9851):1387-95 - PubMed
  31. Nephrol Dial Transplant. 2009 May;24(5):1663-71 - PubMed
  32. Eur J Drug Metab Pharmacokinet. 2006 Apr-Jun;31(2):109-16 - PubMed
  33. Jpn J Pharmacol. 1999 Mar;79(3):275-81 - PubMed
  34. J Biol Chem. 2009 May 29;284(22):14734-43 - PubMed
  35. J Med Chem. 2010 Aug 26;53(16):5979-6002 - PubMed
  36. J Mol Cell Cardiol. 2006 Nov;41(5):845-54 - PubMed
  37. Rev Assoc Med Bras (1992). 2012 Mar-Apr;58(2):133-4 - PubMed
  38. Eur J Heart Fail. 2006 Oct;8(6):658-61 - PubMed
  39. Lancet. 2000 Aug 19;356(9230):608-9 - PubMed
  40. Med Sci Monit. 2009 Dec;15(12):MS12-23 - PubMed
  41. J Card Fail. 2006 Sep;12(7):491-8 - PubMed
  42. Circ Res. 2010 Oct 29;107(9):1044-6 - PubMed
  43. Eur J Heart Fail. 2007 Nov;9(11):1120-7 - PubMed
  44. Circulation. 2004 Apr 20;109(15):1898-903 - PubMed
  45. Am Heart J. 2007 Sep;154(3):602.e1-5 - PubMed
  46. Circulation. 1992 Feb;85(2):504-9 - PubMed
  47. Eur Heart J. 2012 Sep;33(18):2290-6 - PubMed
  48. Lancet. 1992 Jul 11;340(8811):88-92 - PubMed
  49. Circulation. 1997 Sep 16;96(6):1976-82 - PubMed
  50. Lancet. 2010 Apr 10;375(9722):1228-9 - PubMed
  51. Int J Cardiol. 2006 Sep 20;112(2):234-42 - PubMed
  52. J Cardiovasc Pharmacol. 2008 Jun;51(6):611-5 - PubMed
  53. J Am Coll Cardiol. 2006 Oct 3;48(7):1438-47 - PubMed
  54. Int J Cardiol. 2002 Oct;85(2-3):195-7 - PubMed
  55. Lancet. 1998 May 30;351(9116):1657-8 - PubMed
  56. Curr Opin Investig Drugs. 2010 Mar;11(3):349-56 - PubMed
  57. FEBS Lett. 1990 Oct 1;271(1-2):169-77 - PubMed
  58. Pharmacol Ther. 2009 Aug;123(2):151-77 - PubMed
  59. J Am Coll Cardiol. 2006 Aug 1;48(3):545-55 - PubMed
  60. J Biol Chem. 1998 Apr 24;273(17):10261-9 - PubMed
  61. Cardiovasc Res. 2000 May;46(2):214-24 - PubMed
  62. Eur J Heart Fail. 2006 Dec;8(8):790-6 - PubMed
  63. Lancet. 2010 Nov 13;376(9753):1670-81 - PubMed
  64. J Cardiovasc Pharmacol. 2008 Apr;51(4):372-9 - PubMed
  65. Annu Rev Biochem. 2007;76:367-85 - PubMed
  66. Circ Res. 2006 Aug 18;99(4):398-406 - PubMed
  67. Drugs. 2004;64(10):1029-40 - PubMed
  68. JACC Heart Fail. 2014 Dec;2(6):641-9 - PubMed
  69. Circulation. 1995 Aug 15;92(4):778-84 - PubMed
  70. Health Technol Assess. 2006 Sep;10(31):iii-iv, xiii-xvi, 1-239 - PubMed
  71. Nature. 2002 Jan 10;415(6868):198-205 - PubMed
  72. Circulation. 2015 Jan 6;131(1):54-61 - PubMed
  73. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H983-9 - PubMed
  74. Circulation. 1994 Dec;90(6):2748-56 - PubMed
  75. Eur J Heart Fail. 2009 Jan;11(1):6-13 - PubMed
  76. Eur J Clin Pharmacol. 2013 Apr;69(4):901-8 - PubMed
  77. Basic Res Cardiol. 2013 Jul;108(4):356 - PubMed
  78. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5622-7 - PubMed
  79. J Am Coll Cardiol. 2008 Jun 17;51(24):2301-9 - PubMed
  80. Basic Clin Pharmacol Toxicol. 2006 Dec;99(6):391-7 - PubMed
  81. Am Heart J. 2007 Jun;153(6):1055.e1-8 - PubMed
  82. Cardiol Rev. 2008 Nov-Dec;16(6):280-7 - PubMed
  83. Hypertension. 2009 Sep;54(3):591-7 - PubMed
  84. Eur J Heart Fail. 2009 Feb;11(2):119-29 - PubMed
  85. FASEB J. 2004 Nov;18(14):1752-4 - PubMed
  86. Circ Heart Fail. 2013 Jul;6(4):862-8 - PubMed
  87. Eur J Heart Fail. 2008 Jan;10(1):89-95 - PubMed
  88. Circulation. 2003 Jan 28;107(3):477-84 - PubMed
  89. J Biol Chem. 2006 Jul 14;281(28):19469-77 - PubMed
  90. Eur J Heart Fail. 1999 Jun;1(2):197-200 - PubMed
  91. N Engl J Med. 2010 Jan 21;362(3):228-38 - PubMed
  92. N Engl J Med. 1998 Nov 5;339(19):1349-57 - PubMed
  93. Fundam Clin Pharmacol. 2005 Feb;19(1):117-25 - PubMed
  94. J Postgrad Med. 2015 Apr-Jun;61(2):101-8 - PubMed
  95. J Clin Invest. 2010 Dec;120(12):4375-87 - PubMed
  96. Circ Res. 2006 Feb 3;98(2):271-9 - PubMed
  97. N Engl J Med. 2007 Nov 29;357(22):2248-61 - PubMed
  98. Eur Heart J. 2013 Aug;34(31):2453-63 - PubMed
  99. J Am Coll Cardiol. 2010 May 4;55(18):1907-14 - PubMed
  100. Circulation. 2001 Nov 13;104(20):2407-11 - PubMed
  101. J Am Coll Cardiol. 2008 Jul 1;52(1):60-8 - PubMed
  102. Drug Discov Today Dis Mech. 2010 Summer;7(2):e151-e157 - PubMed
  103. Expert Opin Biol Ther. 2010 Jan;10(1):29-41 - PubMed
  104. PLoS One. 2014 May 05;9(5):e94660 - PubMed
  105. Am J Ther. 2011 Nov;18(6):e197-201 - PubMed
  106. Mayo Clin Proc. 2012 Jun;87(6):555-60 - PubMed
  107. Am J Cardiovasc Drugs. 2005;5(4):271-8 - PubMed
  108. Eur Heart J. 2008 Sep;29(17):2171-9 - PubMed
  109. Curr Opin Nephrol Hypertens. 2007 Mar;16(2):129-33 - PubMed
  110. Indian J Biochem Biophys. 2009 Dec;46(6):421-40 - PubMed
  111. J Card Fail. 2009 Apr;15(3):171-81 - PubMed
  112. J Clin Invest. 2008 Jun;118(6):2230-45 - PubMed
  113. Circulation. 2002 Jul 16;106(3):362-7 - PubMed
  114. Mol Med. 2014 Jun 12;20:221-9 - PubMed
  115. Circulation. 1997 Dec 2;96(11):3963-73 - PubMed
  116. Lancet. 2010 Apr 10;375(9722):1255-66 - PubMed
  117. J Am Coll Cardiol. 2006 Aug 1;48(3):556-8 - PubMed
  118. J Cardiovasc Pharmacol. 2011 Apr;57(4):495-504 - PubMed
  119. Heart Lung Circ. 2014 Feb;23(2):105-13 - PubMed
  120. Eur J Heart Fail. 2012 Aug;14(8):803-69 - PubMed
  121. Am J Ther. 2011 Jan;18(1):31-7 - PubMed
  122. Circulation. 2006 Feb 28;113(8):1086-92 - PubMed
  123. Circulation. 2011 Nov 1;124(18):1945-55 - PubMed
  124. J Clin Invest. 2009 May;119(5):1082-5 - PubMed
  125. Eur J Heart Fail. 2011 Jan;13(1):100-6 - PubMed
  126. N Engl J Med. 2014 Sep 11;371(11):993-1004 - PubMed
  127. J Cardiovasc Pharmacol. 2014 Apr;63(4):316-22 - PubMed
  128. Mol Cell Endocrinol. 2012 Mar 24;350(2):310-7 - PubMed
  129. J Clin Invest. 2009 May;119(5):1230-40 - PubMed
  130. J Am Coll Cardiol. 2009 Nov 10;54(20):1850-9 - PubMed
  131. J Cardiovasc Dis Res. 2010 Oct;1(4):191-5 - PubMed
  132. Curr Pharm Des. 2009;15(8):883-92 - PubMed
  133. Am J Cardiol. 2011 Jul 15;108(2):246-51 - PubMed
  134. Circ Heart Fail. 2010 Sep;3(5):627-34 - PubMed
  135. J Cardiovasc Pharmacol. 2000 Dec;36(6):794-801 - PubMed
  136. Circulation. 2002 Aug 20;106(8):920-6 - PubMed
  137. Pharmacol Res. 2005 Apr;51(4):311-8 - PubMed
  138. Basic Res Cardiol. 2009 May;104(3):258-68 - PubMed
  139. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2181-90 - PubMed
  140. J Card Fail. 1997 Dec;3(4):249-54 - PubMed
  141. Lancet. 2008 Oct 4;372(9645):1231-9 - PubMed
  142. J Am Coll Cardiol. 2006 Sep 5;48(5):992-8 - PubMed
  143. Circulation. 1998 Nov 24;98(21):2262-8 - PubMed
  144. Circ Res. 2012 Mar 2;110(5):777-93 - PubMed
  145. Gene Ther. 2008 Dec;15(23):1550-7 - PubMed
  146. J Med Chem. 2006 Jul 13;49(14):4055-8 - PubMed
  147. Br J Pharmacol. 2007 Jan;150(2):143-52 - PubMed
  148. Curr Opin Cell Biol. 2007 Apr;19(2):124-34 - PubMed
  149. Basic Clin Pharmacol Toxicol. 2009 Oct;105(4):262-70 - PubMed
  150. Am J Cardiol. 2009 Dec 15;104(12):1708-16 - PubMed
  151. Am J Cardiol. 2005 Sep 5;96(5A):11F-23F - PubMed
  152. N Engl J Med. 2001 Mar 15;344(11):783-92 - PubMed
  153. Clin Cardiol. 1998 Dec;21(12 ):888-92 - PubMed
  154. Eur J Intern Med. 2011 Oct;22(5):478-84 - PubMed
  155. J Cardiol. 2015 Sep;66(3):195-200 - PubMed
  156. Clin Sci (Lond). 2000 Jul;99(1):27-35 - PubMed
  157. Syst Rev. 2013 Apr 23;2:22 - PubMed
  158. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8683-7 - PubMed
  159. Circ Res. 2010 Oct 29;107(9):1150-61 - PubMed
  160. Clin Sci (Lond). 2007 Aug;113(4):205-12 - PubMed
  161. Diabetes. 2007 Jul;56(7):1834-41 - PubMed
  162. J Card Fail. 2005 Oct;11(8):607-12 - PubMed
  163. Cardiovasc Ther. 2015 Dec;33(6):338-46 - PubMed
  164. JAMA. 2013 Mar 20;309(11):1125-35 - PubMed
  165. Congest Heart Fail. 2003 Mar-Apr;9(2):64-9 - PubMed
  166. Eur J Heart Fail. 2009 Aug;11(8):771-8 - PubMed
  167. J Renin Angiotensin Aldosterone Syst. 2008 Sep;9(3):177-80 - PubMed
  168. Basic Res Cardiol. 2010 Mar;105(2):279-87 - PubMed
  169. JAMA. 2006 Nov 1;296(17):2105-11 - PubMed
  170. Int J Cardiol. 2011 Mar 17;147(3):438-43 - PubMed
  171. Circulation. 2003 Jun 3;107(21):2690-6 - PubMed
  172. Nature. 1995 Nov 23;378(6555):386-90 - PubMed
  173. Nature. 2008 Feb 21;451(7181):919-28 - PubMed
  174. J Biol Chem. 2010 Sep 24;285(39):29932-40 - PubMed
  175. Tex Heart Inst J. 2013;40(2):140-7 - PubMed
  176. Lancet. 2005 Oct 8;366(9493):1267-78 - PubMed
  177. J Bioenerg Biomembr. 2013 Aug;45(4):343-52 - PubMed
  178. Am J Cardiol. 1991 Jan 1;67(1):63-6 - PubMed
  179. Eur J Heart Fail. 2009 Feb;11(2):113-8 - PubMed
  180. J Am Coll Cardiol. 2012 Mar 6;59(10):913-22 - PubMed
  181. Vasc Health Risk Manag. 2013;9:303-19 - PubMed
  182. Circ Res. 2012 May 25;110(11):1474-83 - PubMed
  183. Physiol Rev. 2007 Apr;87(2):457-506 - PubMed
  184. Cardiovasc Drugs Ther. 2016 Apr;30(2):177-88 - PubMed
  185. Circ Res. 2005 Dec 9;97(12):1314-22 - PubMed
  186. Annu Rev Physiol. 2000;62:321-51 - PubMed
  187. Circulation. 2015 May 19;131(20):1763-71 - PubMed
  188. Circ Res. 2004 May 14;94(9):e78-84 - PubMed
  189. Biochem Pharmacol. 2007 Nov 15;74(10):1466-75 - PubMed
  190. J Mol Cell Cardiol. 2011 Oct;51(4):501-5 - PubMed
  191. J Am Coll Cardiol. 1988 Dec;12(6):1464-9 - PubMed
  192. Heart. 2011 Feb;97(4):278-86 - PubMed
  193. Am J Cardiol. 2004 Mar 1;93(5):603-6 - PubMed
  194. Cardiovasc Ther. 2008 Spring;26(1):24-37 - PubMed
  195. J Card Fail. 2008 Jun;14(5):437-44 - PubMed
  196. Eur Heart J. 2011 Aug;32(15):1838-45 - PubMed
  197. J Am Coll Cardiol. 2008 Mar 18;51(11):1112-9 - PubMed
  198. Heart Fail Rev. 2001 Dec;6(4):335-40 - PubMed
  199. Heart. 2002 Nov;88(5):467-9 - PubMed
  200. J Mol Cell Cardiol. 2004 Aug;37(2):417-29 - PubMed
  201. J Cell Mol Med. 2012 Sep;16(9):2227-37 - PubMed
  202. Circulation. 2002 May 28;105(21):2549-55 - PubMed
  203. Circ Heart Fail. 2008 May;1(1):17-24 - PubMed
  204. Circulation. 1994 Apr;89(4):1580-6 - PubMed
  205. Circulation. 2011 Jul 19;124(3):304-13 - PubMed
  206. Eur Heart J. 2004 Apr;25(8):634-41 - PubMed
  207. Am J Cardiol. 1993 Jun 1;71(15):1293-9 - PubMed
  208. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):793-8 - PubMed

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