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Yong BC, Xun FX, Zhao LJ, et al. A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30 years. Springerplus. 2016;5(1):896doi: 10.1186/s40064-016-2353-8.
Yong, B. C., Xun, F. X., Zhao, L. J., Deng, H. W., & Xu, H. W. (2016). A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30 years. SpringerPlus, 5(1), 896. https://doi.org/10.1186/s40064-016-2353-8
Yong, Bi-Cheng, et al. "A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30 years." SpringerPlus vol. 5,1 (2016): 896. doi: https://doi.org/10.1186/s40064-016-2353-8
Yong BC, Xun FX, Zhao LJ, Deng HW, Xu HW. A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30 years. Springerplus. 2016 Jun 27;5(1):896. doi: 10.1186/s40064-016-2353-8. eCollection 2016. PMID: 27386344; PMCID: PMC4923008.
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Springerplus. 2016 Jun 27;5(1):896. doi: 10.1186/s40064-016-2353-8. eCollection 2016.

A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30 years.

SpringerPlus

Bi-Cheng Yong, Fu-Xing Xun, Lan-Juan Zhao, Hong-Wen Deng, Hong-Wen Xu

Affiliations

  1. Department of Pediatric Orthopedics, Guang Zhou Women and Children's Medical Center, Sun Yat-Sen University, 9th Floor, No 9., Jingsui Road, Guangzhou, China.
  2. Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, Orleans, LA USA.

PMID: 27386344 PMCID: PMC4923008 DOI: 10.1186/s40064-016-2353-8

Abstract

The genetic cause of idiopathic congenital talipes equinovarus (ICTEV) is largely unknown. We performed a systematic review to describe the findings from 21 studies that have examined the genetic variants related to ICTEV, and to evaluate the quality of reporting. We found that ICTEV was positively associated with Hox family genes, collagen family genes, GLI3, N-acetylation genes, T-box family genes, apoptotic pathway genes, and muscle contractile family genes. Negative and controversial results were also discussed, and several genes associated with ICTEV were identified. Due to the limitation of the included studies, rare coding variants should be further investigated, sample size should be enlarged, and candidate genes should be replicated in larger ICTEV populations. Epigenetic study, pathways, chromosome capture, and detailed gene-environment interaction will also allow further elucidation of factors involved in ICTEV pathogenesis and may shed light on diagnosis and timely and accurate interventions.

Keywords: Etiology; Genetics; ICTEV

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