Display options
Cite
Hrncic D, Mikić J, Rasic-Markovic A, et al. Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress. Can J Physiol Pharmacol. 2016;94(10):1074-1082doi: 10.1139/cjpp-2015-0581.
Hrncic, D., Mikić, J., Rasic-Markovic, A., Velimirović, M., Stojković, T., Obrenović, R., Rankov-Petrović, B., Šušić, V., Djuric, D., Petronijević, N., & Stanojlovic, O. (2016). Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress. Canadian journal of physiology and pharmacology, 94(10), 1074-1082. https://doi.org/10.1139/cjpp-2015-0581
Hrncic, Dragan, et al. "Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress." Canadian journal of physiology and pharmacology vol. 94,10 (2016): 1074-1082. doi: https://doi.org/10.1139/cjpp-2015-0581
Hrncic D, Mikić J, Rasic-Markovic A, Velimirović M, Stojković T, Obrenović R, Rankov-Petrović B, Šušić V, Djuric D, Petronijević N, Stanojlovic O. Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress. Can J Physiol Pharmacol. 2016 Oct;94(10):1074-1082. doi: 10.1139/cjpp-2015-0581. Epub 2016 May 30. PMID: 27389677.
Copy Download .nbib Format: NLM
Share it on

Can J Physiol Pharmacol. 2016 Oct;94(10):1074-1082. doi: 10.1139/cjpp-2015-0581. Epub 2016 May 30.

Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress.

Canadian journal of physiology and pharmacology

Dragan Hrncic, Jelena Mikić, Aleksandra Rasic-Markovic, Milica Velimirović, Tihomir Stojković, Radmila Obrenović, Bojana Rankov-Petrović, Veselinka Šušić, Dragan Djuric, Nataša Petronijević, Olivera Stanojlovic

Affiliations

  1. a Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.
  2. b Institute of Clinical and Medical Biochemistry, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia.
  3. c Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  4. d Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia.

PMID: 27389677 DOI: 10.1139/cjpp-2015-0581

Abstract

The aim of this study was to examine the effects of a methionine-enriched diet on anxiety-related behavior in rats and to determine the role of the brain oxidative status in these alterations. Adult male Wistar rats were fed from the 30th to 60th postnatal day with standard or methionine-enriched diet (double content comparing with standard diet: 7.7 g/kg). Rats were tested in open field and light-dark tests and afterwards oxidative status in the different brain regions were determined. Hyperhomocysteinemia induced by methionine-enriched diet in this study decreased the number of rearings, as well as the time that these animals spent in the center of the open field, but increased index of thigmotaxy. Oxidative status was selectively altered in the examined regions. Lipid peroxidation was significantly increased in the cortex and nc. caudatus of rats developing hyperhomocysteinemia, but unaltered in the hippocampus and thalamus. Based on the results of this research, it could be concluded that hyperhomocysteinemia induced by methionine nutritional overload increased anxiety-related behavior in rats. These proanxiogenic effects could be, at least in part, a consequence of oxidative stress in the rat brain.

Keywords: anxiety; anxiété; behavior; comportement; hyperhomocysteinemia; hyperhomocystéinémie; methionine; méthionine; nutrition; oxidative stress; rats; stress oxydatif

Publication Types