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Xu C, Tang F, Lu M, et al. Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase - ROS - NF-κB pathway. Can J Physiol Pharmacol. 2016;94(11):1132-1140doi: 10.1139/cjpp-2015-0572.
Xu, C., Tang, F., Lu, M., Yang, J., Han, R., Mei, M., Hu, J., & Wang, H. (2016). Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase - ROS - NF-κB pathway. Canadian journal of physiology and pharmacology, 94(11), 1132-1140. https://doi.org/10.1139/cjpp-2015-0572
Xu, Chonghua, et al. "Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase - ROS - NF-κB pathway." Canadian journal of physiology and pharmacology vol. 94,11 (2016): 1132-1140. doi: https://doi.org/10.1139/cjpp-2015-0572
Xu C, Tang F, Lu M, Yang J, Han R, Mei M, Hu J, Wang H. Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase - ROS - NF-κB pathway. Can J Physiol Pharmacol. 2016 Nov;94(11):1132-1140. doi: 10.1139/cjpp-2015-0572. Epub 2016 May 30. PMID: 27453997.
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Can J Physiol Pharmacol. 2016 Nov;94(11):1132-1140. doi: 10.1139/cjpp-2015-0572. Epub 2016 May 30.

Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase - ROS - NF-κB pathway.

Canadian journal of physiology and pharmacology

Chonghua Xu, Futian Tang, Meili Lu, Jing Yang, Ronghui Han, Meng Mei, Jin Hu, Hongxin Wang

Affiliations

  1. Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Liaoning Medical University, Jinzhou 121001, China.

PMID: 27453997 DOI: 10.1139/cjpp-2015-0572

Abstract

Endothelial cell injury caused by reactive oxygen species (ROS) plays a critical role in the pathogenesis of cardiovascular disorders. Astragaloside IV (AsIV) possesses potent antioxidant properties against oxidative stress through undefined mechanism(s). We sought to investigate whether AsIV protects human umbilical vein endothelial cells (HUVECs) from hydrogen peroxide (H

Keywords: Astragaloside IV; NADPH oxidase; NADPH oxydase; NF-κB; anion superoxyde; astragaloside IV; cellules endothéliales des veines ombilicales humaines; découplage de l’eNOS; eNOS uncoupling; human umbilical vein endothelial cells; hydrogen peroxide; peroxyde d’hydrogen; superoxide anion; tetrahydrobiopterin; tétrahydrobioptérine

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