Display options
Cite
Healy K, Labrique AB, Miranda JJ, et al. Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders. High Alt Med Biol. 2016;17(3):208-213doi: 10.1089/ham.2016.0041.
Healy, K., Labrique, A. B., Miranda, J. J., Gilman, R. H., Danz, D., Davila-Roman, V. G., Huicho, L., León-Velarde, F., & Checkley, W. (2016). Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders. High altitude medicine & biology, 17(3), 208-213. https://doi.org/10.1089/ham.2016.0041
Healy, Katherine, et al. "Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders." High altitude medicine & biology vol. 17,3 (2016): 208-213. doi: https://doi.org/10.1089/ham.2016.0041
Healy K, Labrique AB, Miranda JJ, Gilman RH, Danz D, Davila-Roman VG, Huicho L, León-Velarde F, Checkley W. Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders. High Alt Med Biol. 2016 Sep;17(3):208-213. doi: 10.1089/ham.2016.0041. Epub 2016 Jul 25. PMID: 27454014.
Copy Download .nbib Format: NLM
Share it on

High Alt Med Biol. 2016 Sep;17(3):208-213. doi: 10.1089/ham.2016.0041. Epub 2016 Jul 25.

Dark Adaptation at High Altitude: An Unexpected Pupillary Response to Chronic Hypoxia in Andean Highlanders.

High altitude medicine & biology

Katherine Healy, Alain B Labrique, J Jaime Miranda, Robert H Gilman, David Danz, Victor G Davila-Roman, Luis Huicho, Fabiola León-Velarde, William Checkley

Affiliations

  1. 1 Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University , Baltimore, Maryland.
  2. 2 Program in Global Disease Epidemiology and Control, Department of International Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland.
  3. 3 CRONICAS Center of Excellence in Chronic Diseases , Universidad Peruana Cayetano Heredia, Lima, Peru .
  4. 4 Biomedical Research Unit , A.B. PRISMA, Lima, Peru .
  5. 5 Division of Cardiovascular, Cardiovascular Imaging and Clinical Research Core Laboratory, School of Medicine, Washington University , St. Louis, Missouri.
  6. 6 Centro de Investigación para el Desarrollo Integral y Sostenible and School of Medicine, Universidad Peruana Cayetano Heredia , Lima, Peru .
  7. 7 Departamento de Ciencias Biológicas y Fisiológicas, Universidad Peruana Cayetano Heredia , Lima, Peru .

PMID: 27454014 DOI: 10.1089/ham.2016.0041

Abstract

Healy, Katherine, Alain B. Labrique, J. Jaime Miranda, Robert H. Gilman, David Danz, Victor G. Davila-Roman, Luis Huicho, Fabiola León-Velarde, and William Checkley. Dark adaptation at high altitude: an unexpected pupillary response to chronic hypoxia in Andean highlanders. High Alt Med Biol. 17:208-213, 2016.-Chronic mountain sickness is a maladaptive response to high altitude (>2500 m above sea level) and is characterized by excessive erythrocytosis and hypoxemia resulting from long-term hypobaric hypoxia. There is no known early predictor of chronic mountain sickness and the diagnosis is based on the presence of excessive erythrocytosis and clinical features. Impaired dark adaptation, or an inability to visually adjust from high- to low-light settings, occurs in response to mild hypoxia and may serve as an early predictor of hypoxemia and chronic mountain sickness. We aimed to evaluate the association between pupillary response assessed by dark adaptometry and daytime hypoxemia in resident Andean highlanders aged ≥35 years living in Puno, Peru. Oxyhemoglobin saturation (SpO

Keywords: chronic mountain sickness; hypoxemia; impaired dark adaptation; oxyhemoglobin saturation; portable field dark adaptometer; pupillary contraction

Publication Types

Grant support