Display options
Cite
Strauch LS, Eriksen RØ, Sandgaard M, et al. Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT. Diagnostics (Basel). 2016;6(3)doi: 10.3390/diagnostics6030028.
Strauch, L. S., Eriksen, R. �. �., Sandgaard, M., Kristensen, T. S., Nielsen, M. B., & Lauridsen, C. A. (2016). Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT. Diagnostics (Basel, Switzerland), 6(3), . https://doi.org/10.3390/diagnostics6030028
Strauch, Louise S, et al. "Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT." Diagnostics (Basel, Switzerland) vol. 6,3 (2016). doi: https://doi.org/10.3390/diagnostics6030028
Strauch LS, Eriksen RØ, Sandgaard M, Kristensen TS, Nielsen MB, Lauridsen CA. Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT. Diagnostics (Basel). 2016 Jul 21;6(3). doi: 10.3390/diagnostics6030028. PMID: 27455330; PMCID: PMC5039562.
Copy Download .nbib Format: NLM
Share it on

Diagnostics (Basel). 2016 Jul 21;6(3). doi: 10.3390/diagnostics6030028.

Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT.

Diagnostics (Basel, Switzerland)

Louise S Strauch, Rie Ø Eriksen, Michael Sandgaard, Thomas S Kristensen, Michael B Nielsen, Carsten A Lauridsen

Affiliations

  1. Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. [email protected].
  2. Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark. [email protected].
  3. Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. [email protected].
  4. Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark. [email protected].
  5. Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. [email protected].
  6. Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. [email protected].
  7. Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. [email protected].
  8. Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. [email protected].
  9. Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark. [email protected].

PMID: 27455330 PMCID: PMC5039562 DOI: 10.3390/diagnostics6030028

Abstract

The aim of this study was to provide an overview of the literature available on dynamic contrast-enhanced computed tomography (DCE-CT) as a tool to evaluate treatment response in patients with lung cancer. This systematic review was compiled according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only original research articles concerning treatment response in patients with lung cancer assessed with DCE-CT were included. To assess the validity of each study we implemented Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). The initial search yielded 651 publications, and 16 articles were included in this study. The articles were divided into groups of treatment. In studies where patients were treated with systemic chemotherapy with or without anti-angiogenic drugs, four out of the seven studies found a significant decrease in permeability after treatment. Four out of five studies that measured blood flow post anti-angiogenic treatments found that blood flow was significantly decreased. DCE-CT may be a useful tool in assessing treatment response in patients with lung cancer. It seems that particularly permeability and blood flow are important perfusion values for predicting treatment outcome. However, the heterogeneity in scan protocols, scan parameters, and time between scans makes it difficult to compare the included studies.

Keywords: DCE-CT; Dynamic Contrast-Enhanced CT; lung cancer; treatment response

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. Br J Radiol. 2003;76 Spec No 1:S36-42 - PubMed
  2. Clin Physiol Funct Imaging. 2014 Sep;34(5):340-55 - PubMed
  3. AJR Am J Roentgenol. 2011 Jul;197(1):113-21 - PubMed
  4. Br J Radiol. 2011 Dec;84 Spec No 2:S112-20 - PubMed
  5. Nat Rev Clin Oncol. 2012 Feb 14;9(3):167-77 - PubMed
  6. Diagnostics (Basel). 2013 Apr 03;3(2):261-70 - PubMed
  7. Radiology. 2012 Jun;263(3):865-73 - PubMed
  8. J Clin Epidemiol. 2009 Oct;62(10):1006-12 - PubMed
  9. Br J Radiol. 2003 Apr;76(904):220-31 - PubMed
  10. Radiology. 2011 May;259(2):574-82 - PubMed
  11. AJNR Am J Neuroradiol. 2009 Apr;30(4):793-9 - PubMed
  12. Ann Intern Med. 2011 Oct 18;155(8):529-36 - PubMed
  13. AJR Am J Roentgenol. 2013 Jun;200(6):W603-9 - PubMed
  14. AJR Am J Roentgenol. 2010 Apr;194(4):1116-23 - PubMed
  15. AJR Am J Roentgenol. 2014 Nov;203(5):W497-505 - PubMed
  16. Clin Transl Oncol. 2012 Jun;14(6):437-43 - PubMed
  17. Eur Radiol. 2012 Jul;22(7):1430-41 - PubMed
  18. J Thorac Imaging. 2013 Jul;28(4):253-62 - PubMed
  19. J Biol Regul Homeost Agents. 2014 Oct-Dec;28(4):675-81 - PubMed
  20. Br J Radiol. 2013 Sep;86(1029):20120174 - PubMed
  21. Environ Health Perspect. 1986 Dec;70:261-91 - PubMed
  22. Eur J Cancer. 2009 Jan;45(2):228-47 - PubMed
  23. Asian Pac J Cancer Prev. 2015 ;16(15):6765-8 - PubMed
  24. Eur Radiol. 2013 Aug;23 (8):2127-36 - PubMed
  25. AJR Am J Roentgenol. 2009 Oct;193(4):1090-6 - PubMed
  26. J Clin Oncol. 2008 Mar 10;26(8):1316-23 - PubMed
  27. Eur J Nucl Med Mol Imaging. 2016 Feb;43(2):240-8 - PubMed
  28. AJR Am J Roentgenol. 2006 Jul;187(1):164-9 - PubMed
  29. Exp Biol Med (Maywood). 2010 Jan;235(1):3-9 - PubMed
  30. Cancer Sci. 2013 Apr;104(4):445-52 - PubMed
  31. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):417-24 - PubMed
  32. Eur Radiol. 2004 Jul;14 (7):1226-33 - PubMed
  33. Eur J Nucl Med Mol Imaging. 2006 Jan;33(1):22-8 - PubMed
  34. Radiol Clin North Am. 2009 Jan;47(1):161-78 - PubMed
  35. Invest Radiol. 2012 Jan;47(1):2-4 - PubMed
  36. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 - PubMed
  37. Target Oncol. 2013 Mar;8(1):15-26 - PubMed
  38. Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1375-80 - PubMed
  39. AJR Am J Roentgenol. 2013 Jan;200(1):8-19 - PubMed
  40. Lung Cancer. 2010 Jul;69(1):71-6 - PubMed
  41. CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30 - PubMed
  42. Br J Radiol. 2006 Jul;79(943):578-83 - PubMed
  43. J Thorac Oncol. 2015 Jan;10(1):164-71 - PubMed
  44. Clin Transl Oncol. 2016 Jan;18(1):47-57 - PubMed
  45. Acad Radiol. 2000 Oct;7(10 ):840-50 - PubMed
  46. Eur J Radiol. 2012 Nov;81(11):3542-50 - PubMed
  47. Eur Radiol. 2010 Dec;20(12 ):2890-8 - PubMed

Publication Types