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Tauchi T, Ohyashiki K, Kodama A, et al. Two Additional Acute Nonlymphocytic Leukemia Patients with a Sole Chromosome Abnormality of Trisomy 4. Leuk Lymphoma. 1990;2(1):131-5doi: 10.3109/10428199009042523.
Tauchi, T., Ohyashiki, K., Kodama, A., Iwabuchi, A., Ohyashiki, J. H., & Toyama, K. (1990). Two Additional Acute Nonlymphocytic Leukemia Patients with a Sole Chromosome Abnormality of Trisomy 4. Leukemia & lymphoma, 2(1), 131-5. https://doi.org/10.3109/10428199009042523
Tauchi, T, et al. "Two Additional Acute Nonlymphocytic Leukemia Patients with a Sole Chromosome Abnormality of Trisomy 4." Leukemia & lymphoma vol. 2,1 (1990): 131-5. doi: https://doi.org/10.3109/10428199009042523
Tauchi T, Ohyashiki K, Kodama A, Iwabuchi A, Ohyashiki JH, Toyama K. Two Additional Acute Nonlymphocytic Leukemia Patients with a Sole Chromosome Abnormality of Trisomy 4. Leuk Lymphoma. 1990;2(1):131-5. doi: 10.3109/10428199009042523. PMID: 27456580.
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Leuk Lymphoma. 1990;2(1):131-5. doi: 10.3109/10428199009042523.

Two Additional Acute Nonlymphocytic Leukemia Patients with a Sole Chromosome Abnormality of Trisomy 4.

Leukemia & lymphoma

T Tauchi, K Ohyashiki, A Kodama, A Iwabuchi, J H Ohyashiki, K Toyama

Affiliations

  1. a First Department of Internal Medicine, Tokyo Medical College, Tokyo, 160, Japan.
  2. b Chromosome Laboratory [A.K.], Tokyo Medical College, Tokyo, 160, Japan.

PMID: 27456580 DOI: 10.3109/10428199009042523

Abstract

We report two cases of acute nonlymphocytic leukemia (ANLL) in which the circulating leukemic cells showed trisomy of chromosome 4 as the sole cytogenetic abnormality. Trisomy 4 is rarely found in hematopoietic neoplasia and until now the few reported patients had ANLL or myelodysplastic syndrome (MDS). In these two ANLL patients with trisomy 4 (FAB-M2 and M4), we were unable to obtain information on exposure to mutagenic/carcinogenic agents. Furthermore, both of them did not manifest underlying dysplastic changes in the bone marrow and also had cells with a normal karyotype. In addition the presence of cells with trisomy 4 without associated marrow dysplasia indicates that this karyotypic change may also occur in some ANLL patients without preexisting MDS.

Keywords: ANLL; chromosome aberration; trisomy 4

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