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Salvi AE, Metelli GP, Bosco A, et al. Spontaneous bilateral Achilles tendon rupture in a patient treated with oral levofloxacin. J Orthop Traumatol. 2007;8(2):86-90doi: 10.1007/s10195-007-0168-7.
Salvi, A. E., Metelli, G. P., Bosco, A., Berizzi, A., Hacking, S. A., & Cantalamessa, A. (2007). Spontaneous bilateral Achilles tendon rupture in a patient treated with oral levofloxacin. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 8(2), 86-90. https://doi.org/10.1007/s10195-007-0168-7
Salvi, A E, et al. "Spontaneous bilateral Achilles tendon rupture in a patient treated with oral levofloxacin." Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology vol. 8,2 (2007): 86-90. doi: https://doi.org/10.1007/s10195-007-0168-7
Salvi AE, Metelli GP, Bosco A, Berizzi A, Hacking SA, Cantalamessa A. Spontaneous bilateral Achilles tendon rupture in a patient treated with oral levofloxacin. J Orthop Traumatol. 2007 Jun;8(2):86-90. doi: 10.1007/s10195-007-0168-7. Epub 2007 Jun 08. PMID: 27519893; PMCID: PMC4484540.
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J Orthop Traumatol. 2007 Jun;8(2):86-90. doi: 10.1007/s10195-007-0168-7. Epub 2007 Jun 08.

Spontaneous bilateral Achilles tendon rupture in a patient treated with oral levofloxacin.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology

A E Salvi, G P Metelli, A Bosco, A Berizzi, S A Hacking, A Cantalamessa

Affiliations

  1. Orthopaedics and Traumatology Department, Mellino Mellini Hospital Trust Civil Hospital of Iseo, I-25049, Iseo (BS), Italy. [email protected].
  2. Orthopaedics and Traumatology Department, Mellino Mellini Hospital Trust Civil Hospital of Iseo, I-25049, Iseo (BS), Italy.
  3. Accident and Emergency Department Mellino Mellini Hospital Trust, Civil Hospital of Iseo, Iseo (BS), Italy.
  4. Orthopaedics and Traumatology Department, University of Padua, Padua, Italy.
  5. Department of Orthopaedics JTN Wong Labs for Mineralized Tissue Research, McGill University, Montreal, Quebec, Canada.
  6. Department of Internal Medicine Mellino Mellini Hospital Trust, Civil Hospital of Iseo, Iseo (BS), Italy.

PMID: 27519893 PMCID: PMC4484540 DOI: 10.1007/s10195-007-0168-7

Abstract

A case of bilateral rupture of the Achilles tendon in a patient treated with levofloxacin for cystitis is reported. A 76-year-old woman suddenly developed painful ankles one day after levofloxacin treatment. Drug therapy was switched to amoxicillin/clavulanate on the fourth day. Sonography revealed a serious condition of tendinosis with complete bilateral full-thickness rupture on day 6. Tendons were both repaired in the same surgical session. Pathological anatomy of the specimens reported fatty tissue lobules with panniculitis and histiocytosis. Ankles were immobilized postoperatively with a plaster cast. Achilles tendon rupture may occur as an adverse side effect of short-term use of levofloxacin, a fluoroquinolone antibiotic. This adverse effect is a rare and poorly understood complication of this antibiotic therapy. A review of the literature is provided.

Keywords: Achilles tendon; Antibiotic; Cystitis; Fluoroquinolone; Levofloxacin; Tendinosis; Tendon rupture

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