Cancer Res. 2016 Sep 01;76(17):4924-30. doi: 10.1158/0008-5472.CAN-16-1443. Epub 2016 Aug 12.

Challenging Roadblocks to Cancer Cure.

Cancer research

Massimo Loda

PMID: 27520451 DOI: 10.1158/0008-5472.CAN-16-1443

Abstract

The Pezcoller Symposium in Trento, Italy, June 2015, focused entirely on the question of why advanced cancer cure is so uncommon despite the extraordinarily rapid growth of invaluable therapeutic information. Participants were asked to define and to critically evaluate real and potential obstacles to permanent disease eradication. High-level concepts on potential road blocks to cures as well as opportunities for intervention in diverse areas of investigation ranging from genomic alterations to metabolism, microenvironment, immunity, and mechanotransduction were discussed. Provocative concepts and novel therapeutic avenues were proposed. What follows is a critical analysis of the highlights of this meeting. Cancer Res; 76(17); 4924-30. ©2016 AACR.

©2016 American Association for Cancer Research.

MeSH terms

• Humans
• Medical Oncology*
• Neoplasms / etiology
• Neoplasms / therapy

Publication Types

• Journal Article
• Research Support, U.S. Gov't, Non-P.H.S.
• Research Support, N.I.H., Extramural
• Research Support, Non-U.S. Gov't

Grant support

• R01 CA131945/CA/NCI NIH HHS/United States
• R01 CA187918/CA/NCI NIH HHS/United States