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Shaw R, Elliott WH. Bile acids: LXI. Synthesis and properties of conjugates of 5α-bile acids. Lipids. 1980;15(10):805-10doi: 10.1007/BF02534369.
Shaw, R., & Elliott, W. H. (1980). Bile acids: LXI. Synthesis and properties of conjugates of 5α-bile acids. Lipids, 15(10), 805-10. https://doi.org/10.1007/BF02534369
Shaw, R, and Elliott, W H. "Bile acids: LXI. Synthesis and properties of conjugates of 5α-bile acids." Lipids vol. 15,10 (1980): 805-10. doi: https://doi.org/10.1007/BF02534369
Shaw R, Elliott WH. Bile acids: LXI. Synthesis and properties of conjugates of 5α-bile acids. Lipids. 1980 Oct;15(10):805-10. doi: 10.1007/BF02534369. PMID: 27520782.
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Lipids. 1980 Oct;15(10):805-10. doi: 10.1007/BF02534369.

Bile acids: LXI. Synthesis and properties of conjugates of 5α-bile acids.

Lipids

R Shaw, W H Elliott

Affiliations

  1. Edward A. Doisy Department of Biochemistry, Saint Louis University School of Medicine, 63104, St. Louis, MO.

PMID: 27520782 DOI: 10.1007/BF02534369

Abstract

Allo bile acids and their taurine- and glycine-conjugates were synthesized by modification of existing procedures. Their chromatographic and spectral properties were investigated and compared with the 5β-analogs. Some of the naturally occurring 5α- and 5β-conjugates were separable by high performance liquid chromatography via straight-phase (Corasil II column) or reverse-phase systems (μBondapak/C18 column), though unsuccessful with thin layer or gas liquid chromatography. Differences between the C-5 epimers in the infrared and proton magnetic resonance spectra could be attributed to the configurations at the A/B ring junction and the configuration of the 3-hydroxyl group. The calcium salts of the allo compounds were generally less soluble in water than the 5β-isomers.

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