Display options
Cite
Wright JL, Ermine CM, Jørgensen JR, et al. Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury. Front Cell Neurosci. 2016;10:177doi: 10.3389/fncel.2016.00177.
Wright, J. L., Ermine, C. M., Jørgensen, J. R., Parish, C. L., & Thompson, L. H. (2016). Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury. Frontiers in cellular neuroscience, 10177. https://doi.org/10.3389/fncel.2016.00177
Wright, Jordan L, et al. "Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury." Frontiers in cellular neuroscience vol. 10 (2016): 177. doi: https://doi.org/10.3389/fncel.2016.00177
Wright JL, Ermine CM, Jørgensen JR, Parish CL, Thompson LH. Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury. Front Cell Neurosci. 2016 Jul 05;10:177. doi: 10.3389/fncel.2016.00177. eCollection 2016. PMID: 27458346; PMCID: PMC4932119.
Copy Download .nbib Format: NLM
Share it on

Front Cell Neurosci. 2016 Jul 05;10:177. doi: 10.3389/fncel.2016.00177. eCollection 2016.

Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury.

Frontiers in cellular neuroscience

Jordan L Wright, Charlotte M Ermine, Jesper R Jørgensen, Clare L Parish, Lachlan H Thompson

Affiliations

  1. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC Australia.
  2. NsGene, Ballerup Denmark.

PMID: 27458346 PMCID: PMC4932119 DOI: 10.3389/fncel.2016.00177

Abstract

A number of studies have shown that damage to brain structures adjacent to neurogenic regions can result in migration of new neurons from neurogenic zones into the damaged tissue. The number of differentiated neurons that survive is low, however, and this has led to the idea that the introduction of extrinsic signaling factors, particularly neurotrophic proteins, may augment the neurogenic response to a level that would be therapeutically relevant. Here we report on the impact of the relatively newly described neurotrophic factor, Meteorin, when over-expressed in the striatum following excitotoxic injury. Birth-dating studies using bromo-deoxy-uridine (BrdU) showed that Meteorin did not enhance injury-induced striatal neurogenesis but significantly increased the proportion of new cells with astroglial and oligodendroglial features. As a basis for comparison we found under the same conditions, glial derived neurotrophic factor significantly enhanced neurogenesis but did not effect gliogenesis. The results highlight the specificity of action of different neurotrophic factors in modulating the proliferative response to injury. Meteorin may be an interesting candidate in pathological settings involving damage to white matter, for example after stroke or neonatal brain injury.

Keywords: GDNF; brain repair; forebrain injury; neurogenesis; oligodendrogenesis; striatum

References

  1. Neuropathol Appl Neurobiol. 2015 Apr;41(3):347-70 - PubMed
  2. EMBO J. 2004 May 5;23(9):1998-2008 - PubMed
  3. PLoS One. 2010 Jun 11;5(6):e11016 - PubMed
  4. Glia. 2009 Jun;57(8):835-49 - PubMed
  5. J Neurosci. 2004 Mar 3;24(9):2133-42 - PubMed
  6. J Clin Invest. 2003 Jun;111(12):1843-51 - PubMed
  7. Exp Neurol. 1993 Oct;123(2):271-83 - PubMed
  8. J Cereb Blood Flow Metab. 2012 Feb;32(2):387-98 - PubMed
  9. Anat Rec. 1991 Dec;231(4):482-97 - PubMed
  10. Neurobiol Dis. 2008 Jun;30(3):343-52 - PubMed
  11. Stroke. 1996 Sep;27(9):1641-6; discussion 1647 - PubMed
  12. PLoS One. 2013 Dec 02;8(12):e81750 - PubMed
  13. Eur J Neurosci. 1999 Dec;11(12):4357-66 - PubMed
  14. J Mol Neurosci. 2009 Sep;39(1-2):104-16 - PubMed
  15. Mol Cell Neurosci. 2003 Nov;24(3):603-13 - PubMed
  16. Neurosurg Clin N Am. 2007 Jan;18(1):169-81, xi - PubMed
  17. Glia. 1996 Apr;16(4):368-82 - PubMed
  18. J Comp Neurol. 1993 Jan 1;327(1):123-32 - PubMed
  19. APMIS. 1988 Oct;96(10):857-81 - PubMed
  20. Stroke. 2006 Sep;37(9):2361-7 - PubMed
  21. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4710-5 - PubMed
  22. J Cell Sci. 2010 Jun 1;123(Pt 11):1959-68 - PubMed
  23. J Cereb Blood Flow Metab. 2003 Mar;23(3):263-74 - PubMed
  24. J Neurosci. 2007 Jan 17;27(3):657-64 - PubMed
  25. Neurosci Lett. 2006 Jul 31;403(1-2):63-7 - PubMed
  26. Neuroscience. 1991;45(3):529-39 - PubMed
  27. Nat Med. 2002 Sep;8(9):963-70 - PubMed
  28. Mol Med Rep. 2015 Aug;12(2):1817-23 - PubMed
  29. Gene Ther. 2012 May;19(5):483-93 - PubMed
  30. J Anat. 1970 May;106(Pt 3):471-87 - PubMed
  31. Exp Neurol. 2005 Sep;195(1):71-80 - PubMed
  32. Restor Neurol Neurosci. 2012;30(3):225-36 - PubMed
  33. J Neurosci. 2001 Sep 1;21(17):6706-17 - PubMed
  34. Neuroscience. 2001;106(1):27-41 - PubMed
  35. Neurobiol Dis. 2011 Jan;41(1):160-8 - PubMed
  36. Mol Cell Neurosci. 2003 Sep;24(1):171-89 - PubMed
  37. Clin Dev Immunol. 2013;2013:746068 - PubMed
  38. Ann Neurol. 2002 Dec;52(6):802-13 - PubMed
  39. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202 - PubMed
  40. Exp Physiol. 1991 Sep;76(5):639-65 - PubMed
  41. Glia. 2010 Oct;58(13):1610-9 - PubMed

Publication Types